Clinical trials: Disorders of Gut-brain Interaction
Self-hypnosis, Functional Bowel Disorder
Hypnotherapy With Audiofiles for Children and Adolescents With Disorders of Gut-brain Interactions in Sweden -a Feasibility Study
This study aims at testing the effect and feasibility of a new treatment strategy - hypnotherapy mediated with audio files - for children and adolescents with disorders of gut-brain-interaction (DGBI) in Sweden.
- Conditions
- Self-hypnosis, Functional Bowel Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT06493097
- Testing
- Gut-directed hypnotherapy via audio files
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Abdominal Pain (AP), Disorders of Gut-brain Interaction
Transauricular Neurostimulation for Abdominal Pain Due to DGBI
This single-site, open-label pilot study will evaluate transcutaneous auricular neurostimulation using the Sparrow Link device as a treatment for adolescents aged 12 to 18 years with abdominal pain related to disorders of…
- Trial name
- NCT07798180
- Testing
- Transcutaneous auricular neurostimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nationwide Children's Hospital
Autism Spectrum Disorder
Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters
The purpose of this study is to assess the effects of a 6-months supplementation with probiotic Vivomixx® on inflammatory and gastrointestinal (GI) biomarkers, gastrointestinal disturbances, behavioral and developmental profiles…
- Trial name
- NCT02708901
- Testing
- Vivomixx®
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- IRCCS Fondazione Stella Maris
Anxiety and Depression, Disorders of Gut-brain Interaction
Development of an Online ACT Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to develop and test the iACTforDGBI intervention in a sample of Swedish individuals with DGBI (Disorders of Gut-Brain Interaction).
- Trial name
- iACTforDGBI (NCT06309004)
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Healthy Subjects, COVID-19 Pneumonia
Jing Si Herbal Tea for Long-Coronavirus Disease(COVID) Gut-brain Interaction
Dyspepsia refers to chronic or recurrent upper gastrointestinal symptoms. According to the Rome IV criteria, functional dyspepsia (FD) symptoms included meal related fullness, early satiation, epigastric pain or burning which are…
- Conditions
- Healthy Subjects, COVID-19 Pneumonia, Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
- Trial name
- NCT05668104
- Testing
- Jing Si Herbal Tea Liquid Packet
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Glucose Intolerance, Obesity
Effect of a Low-carb Dietary Intervention in Obese Patients: a Pilot Trial
Effects of a 6 months low-carb dietary intervention on glycemic control, body composition and gut-brain interaction in obese and lean patients with and without glucose intolerance or diabetes
- Trial name
- NCT04234373
- Testing
- Low Carb diet
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
DGBI, Depression/Anxiety
Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to assess the acceptability, feasibility, and usability of the iACTforDGBI intervention among patients with Disorders of Gut-Brain Interaction (DGBI).
- Trial name
- iACTforDGBI (NCT06887751)
- Testing
- Acceptance and Commitment Therapy (ACT), Psychoeducation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Örebro University, Sweden
Functional Dyspepsia, Epigastric Pain Syndrome
Cognitive Behavioral Therapy for Functional Dyspepsia (Epigastric Pain Syndrome and Postprandial Distress Syndrome Subtypes)
The goal of this clinical trial is to learn whether adding Cognitive Behavioral Therapy (CBT) to standard medical treatment can improve symptoms in adults with Functional Dyspepsia.
- Conditions
- Functional Dyspepsia, Epigastric Pain Syndrome, Postprandial Distress Syndrome
- Trial name
- FD-CBT (NCT07577089)
- Testing
- Optimized Standard Treatment (OPT), Cognitive Behavioral Therapy + Optimized Standard Treatment (CBT + OPT)
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
Brain-Gut-Microbiota Interaction in IBS
Are you what you eat? How can dietary components influence microbial composition of the gut and function of the peripheral and central nervous system? The gut and brain is linked through complex mechanisms of sensorimotor…
- Trial name
- NCT04296552
- Testing
- Dietary lowFODMAP intervention
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Functional Dyspepsia
Effect of Amitriptyline and Trifluoperazine on Patients With Functional Dyspepsia
The goal of this clinical trial is to assess and compare the effect of amitriptyline and trifluoperazine in improving dyspeptic symptoms in patients with functional dyspepsia.
- Trial name
- NCT07008235
- Testing
- Tablet Amitriptyline 10 milligrams, Tablet Trifluoperazine 1 milligrams twice daily, Standard First-Line Therapy
- Where
- Bangladesh
- Volunteers
- 120 people
- Sponsor
- Md. Moktadirul Hoque Shuvo
Irritable Bowel Syndrome, Healthy Subjects
Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction
Patients with disorders of gut-brain interaction (DGBI) often present gastrointestinal symptoms that do not show noticeable irregularities in standard examinations.
- Conditions
- Irritable Bowel Syndrome, Healthy Subjects, Functional Gastrointestinal Disorders, Laryngopharyngeal Reflux
- Trial name
- NCT06205446
- Testing
- Healthy subjects : abdominal breathing, Laryngopharyngeal reflux disease subjects : abdominal breathing, Dyspepsia subjects : abdominal breathing
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
MTBI - Mild Traumatic Brain Injury
Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and…
- Trial name
- NCT05090007
- Testing
- magnetic resonance image, gut microbiota
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Functional Gastrointestinal Disorders
Exploring Novel Therapeutic Approaches for Disorders of Gut-Liver-Brain Interaction-H1/H2
Functional dyspepsia (FD) is associated with inflammatory responses caused by the release of histamine from eosinophils and mast cells, leading to increased intestinal mucosal permeability, which is a key pathogenic mechanism.
- Trial name
- NCT07857941
- Testing
- Famotidine, Levocetirizine, Fuyuan Gasmin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Cognitive-behavioral Therapy for the Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) is a challenging gastrointestinal disorder, and proton pump inhibitors (PPIs) are typically the first line of treatment.
- Trial name
- NCT06939465
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Hualien Tzu Chi General Hospital
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Functional Dyspepsia, Irritable Bowel Syndrome
Psychoemotional Status and Functional Gastrointestinal Disorders
This prospective cohort study will evaluate the influence of psychoemotional status on the clinical course and quality of life of adult patients with functional dyspepsia and/or irritable bowel syndrome diagnosed according to…
- Trial name
- NCT07539051
- Testing
- Questionnaire and Symptom Assessment, Helicobacter pylori Status Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Center of New Medical Technologies
DGBI, Depression/Anxiety
Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to assess the efficacy and cost-effectiveness of the iACTforDGBI intervention among adults with Disorders of Gut-Brain Interaction (DGBI) and psychological distress.
- Trial name
- iACTforDGBI (NCT07521709)
- Testing
- Acceptance and Commitment Therapy with explicit self-compassion training, Education
- Where
- Sweden
- Sponsor
- Örebro University, Sweden
Disorders of Gut-brain Interaction, Lifestyle and Dietary Interventions
Comprehensive Management Strategies for Gastroesophageal Reflux Disease: A Study of Multidimensional Interventions and Health Impacts
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder, with around 80% of patients experiencing nighttime symptoms.
- Conditions
- Disorders of Gut-brain Interaction, Lifestyle and Dietary Interventions, Gastroesophageal Reflux Disease
- Trial name
- NCT07754721
- Testing
- Dietary intervention guided by a nutritionist, Written dietary education intervention
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- Hualien Tzu Chi General Hospital
Irritable Bowel Syndrome
Effect of Bifidobacterium on Irritable Bowel Syndrome
There has been no data on effect of Bifidobacterium breve on symptoms of patients with irritable bowel syndrome (IBS). We hypothesized that Bifidobacterium breve is effective on symptoms of IBS patients.
- Trial name
- PBIBS (NCT00737841)
- Testing
- Bifidobacterium breve
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Tohoku University
Crohn Disease
Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease
Multidisciplinary techniques such as multimodal neuroimaging, microbiology, and bioinformatics were applied to study the differences in correlation characteristics between gut microbes, functional brain networks, and peripheral…
- Trial name
- NCT06364722
- Testing
- Acupuncture treatment
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian