Clinical trials: Disorders of the Autonomic Nervous System
Ventricular Septal Defect, Closure; Interventricular Septum
The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters
In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.
- Conditions
- Ventricular Septal Defect, Closure; Interventricular Septum, Autonomic Nervous System Imbalance
- Trial name
- NCT04859036
- Testing
- 24 hours ambulatory Holter monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Complex Regional Pain Syndromes
Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter
The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions.
- Trial name
- NCT06468384
- Testing
- thoracic erector spinae plane (ESP) block
- Volunteers
- 15 people
- Sponsor
- Pamukkale University
Pain
Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain
The purpose of the study is to evaluate the efficacy and safety of OraVescent fentanyl treatment compared to placebo treatment monthly over a 12-week treatment period in alleviating breakthrough pain (BTP) in opioid-tolerant…
- Trial name
- NCT00343733
- Testing
- OraVescent Fentanyl
- Where
- 21 sites in United States
- Volunteers
- 120 people
- Sponsor
- Cephalon
Spinal Cord Injury, Orthostatic Hypertension
Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury
The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury.
- Conditions
- Spinal Cord Injury, Orthostatic Hypertension, Autonomic Dysreflexia
- Trial name
- NCT07504055
- Testing
- Spinal Cord Transcutaneous Stimulation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Louisville
Hypertension, Oxidative Stress
Effect of Antioxidant Supplementation on the Autonomic Balance
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events.
- Conditions
- Hypertension, Oxidative Stress, Autonomic Imbalance, Insulin Resistance
- Trial name
- NCT03510221
- Testing
- Antioxidants capsules
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Pain
The Effect of Intravenous Lidocaine on Allodynia
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00659633
- Testing
- lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Major Depressive Disorder
Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)
This study will evaluate the short term effects of respiratory-gated transcutaneous vagus nerve stimulation on the regulation of cardiovagal activity, depressive symptomatology and immune function in subjects with major…
- Trial name
- NCT04607226
- Testing
- Active transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Epilepsy, Hypothalamus
Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy
Patients with drug-resistant epilepsy may have cardiac dysautonomia, with reduced heart rate variability and increased sympathetic tone.
- Conditions
- Epilepsy, Hypothalamus, Seizures- Cardiac Dysautonomia, SUDEP
- Trial name
- HYPOLEPSIE (NCT07888543)
- Testing
- MRI scan, electrocardiogram
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve
Two Measures of Tactile Acuity in CRPS Type I Patients
This study aims to investigate whether two different measures of tactile acuity lead to comparable results in patients diagnosed with CRPS Type I of the upper extremity.
- Conditions
- CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve, Healthy Controls
- Trial name
- NCT01888783
- Testing
- Tactile acuity measured by 2PD and the GOT
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Full Spectrum
A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by…
- Trial name
- NCT06501131
- Testing
- full-spectrum light exposure, specific spectrum absence light exposure
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Sarcopenia, Fatigue
Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study
This study aims to explore the relationship between sarcopenia, fatigue, and orthostatic intolerance in older adults. It will be conducted among geriatric patients attending Ain Shams University Hospitals.
- Conditions
- Sarcopenia, Fatigue, Orthostatic Intolerance
- Trial name
- NCT07564830
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
ROHHAD, Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation
International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation (ROHHAD) Registry
The Center for Autonomic Medicine in Pediatrics (CAMP) has collaborated with doctors from around the world to build the first International ROHHAD (Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic…
- Trial name
- NCT03135730
- Testing
- ROHHAD
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Multiple System Atrophy, Dementia With Lewy Bodies (DLB)
Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and…
- Conditions
- Multiple System Atrophy, Dementia With Lewy Bodies (DLB), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD)
- Trial name
- NCT07805967
- Testing
- We did not apply any interventions; only observational research was conducted.
- Where
- 20 sites in China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Stroke
Effects of Task-Based Mirror Therapy for Post-stroke Shoulder-Hand Syndrome
The study aims to determine the effects of task-based mirror therapy on edema, pain and upper limb motor function with shoulder-hand syndrome in post stroke patients.
- Trial name
- NCT07428811
- Testing
- Task based mirror therapy, Conventional exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Diabete Type 2
Normast3 for Adults With Diabetic Polyneuropathy
The goal of this clinical trial is to find out if a new supplement called Normast® 3 can help reduce nerve pain and improve nerve function in adults with diabetic polyneuropathy (DPN).
- Trial name
- NCT07689214
- Testing
- Normast® 3 - a food for special medical purposes (FSMP) containing co-micronized palmitoylethanolamide (PEA) with rutin and hydroxytyrosol. It is designed to support the management of diabetic polyneu
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Postural Tachycardia Syndrome
Dopamine in Orthostatic Tolerance
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate.
- Trial name
- NCT00748228
- Testing
- dietary sodium
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Migraine Disorders
Botox Injection in Treatment of Chronic Migraine
Chronic migraine is in many cases a most disabling condition. Chronic migraine is defined as headaches for at least 15 days per month, of which 8 days have typical migraine features.
- Trial name
- NCT02259075
- Testing
- Botulinum Toxin Type A
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
Multiple System Atrophy
GDNF Gene Therapy for Multiple System Atrophy
The objective of this randomized, double-blinded, placebo-controlled Phase 1 investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a possible or…
- Trial name
- NCT04680065
- Testing
- AAV2-GDNF gene therapy
- Where
- 7 sites in United States
- Volunteers
- 9 people
- Sponsor
- Brain Neurotherapy Bio, Inc.
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
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