Clinical trials: Disseminated Fungal Infection
Serious Fungal Infections
Non-Interventional Post Marketing Surveillance Study To Observe The Safety And Efficacy Of Vfend® IV
This is non-interventional study of voriconazole IV formulation in clinical use, which was mandated by the Korean government agency following the approval of Vfend in the Republic of Korea.
- Trial name
- NCT01073618
- Testing
- voriconazole IV
- Volunteers
- 692 people
- Sponsor
- Pfizer
Invasive Candidiasis; Treatment With Echinocandin
Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.
The study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management.
- Trial name
- EMPIRICAND (NCT02333448)
- Testing
- Blood sample taken on the day the treatment is initiated, Blood sample taken on day 3 after initiation of treatment, Blood sample taken on day 5 after initiation of
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Invasive Fungal Infections, Pharmacokinetics
Pharmacokinetics of Isavuconazole in Patients in the Intensive Care Unit
20 patients admitted to the ICU department and receiving isavuconazole as part of standard care for the treatment of fungal infections will be included in the study.
- Conditions
- Invasive Fungal Infections, Pharmacokinetics, Intensive Care Unit
- Trial name
- ICONIC (NCT04777058)
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome
The purpose of this study is to compare the effects, good and/or bad, of posaconazole and micafungin in preventing fungal infections after chemotherapy for acute leukemia or myelodysplastic syndrome.
- Trial name
- NCT01200355
- Testing
- micafungin, posaconazole
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bacterial Infection
Mastering Hospital Antimicrobial Resistance and Its Spread Into the Community
Detailed activity: Family members and caregivers of carrier residents will be screened for ESBL and MRSA. Screening will be performed by obtaining nares and perirectal cultures.
- Trial name
- NCT00765778
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neutropenia, Hematopoietic Stem Cell Transplantation
Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Conditions
- Neutropenia, Hematopoietic Stem Cell Transplantation, Invasive Fungal Disease
- Trial name
- NCT01135589
- Testing
- Micafungin
- Where
- 7 sites in South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Liver Transplant Infection, Fungal Infection
Rezafungin Prophylaxis in Liver Transplant
This is an interventional study to evaluate the efficacy of rezafungin, a new echinocandin, for the prevention of invasive fungal infections (IFIs) after liver transplantation.
- Trial name
- NCT06774144
- Testing
- Rezafungin, Standard of care antifungal prophylaxis
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- Fernanda P Silveira, MD, MS
Invasive Candidiases, Abdominal Infection
A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
This is a multicenter, prospective, open-label, randomized trial. Patients with severe abdominal condition developing severe sepsis or septic shock and receiving broad spectrum antibiotic and antifungal treatment will be…
- Trial name
- NCT03090334
- Testing
- De-escalation
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Candidemia
Negative Beta Glucan in ICU Patients
This is a prospective study aimed at testing a strategy of early initiation of an antifungal agent to patients admitted to intensive care units (ICUs) at risk for invasive candidiasis.
- Trial name
- NCT01734525
- Testing
- Anidulafungin
- Where
- Brazil
- Volunteers
- 85 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Fungemia, Mycoses
Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients
The aim of the study is to determine viable use of caspofungin in post-OLTx patients, and to demonstrate in particular the effectiveness, understood as the ability to reduce the incidence of invasive fungal infections, and to…
- Trial name
- CPHRLTX (NCT01260974)
- Testing
- Caspofungin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera di Padova
Invasive Candidiasis
Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study
To evaluate the efficacy and safety of anidulafungin in the treatment of systemic fungal infections in intensive care and critical care unit patients.
- Trial name
- ICE (NCT00689338)
- Testing
- Anidulafungin, Fluconazole, Voriconazole
- Where
- 61 sites in Austria, Belgium and 17 more
- Volunteers
- 216 people
- Sponsor
- Pfizer
Mycobacterium Avium-intracellulare Infection, HIV Infections
The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients
To compare the efficacy and safety of clarithromycin alone versus rifabutin alone versus the two drugs in combination for the prevention or delay of Mycobacterium avium Complex (MAC) bacteremia or disseminated MAC disease.
- Trial name
- NCT00001030
- Testing
- Clarithromycin, Rifabutin
- Where
- 42 sites in United States, Tanzania
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bloodstream Infections, Bacteremia and Sepsis
Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections
Bloodstream infections (BSIs) are associated with high morbidity and mortality, and delays in initiating appropriate antimicrobial therapy significantly worsen clinical outcomes.
- Conditions
- Bloodstream Infections, Bacteremia and Sepsis, Fungemia
- Trial name
- CEMP-RDI (NCT07408544)
- Testing
- Multiplex PCR-Based Rapid Diagnostic Test, Standard Microbiological Diagnostic Methods
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Medipol University Hospital
Fungal Invasive Disease
Predictive Factors of Mortality in Invasive Fungal Disease in Post-surgical Critical Care Unit
Invasive fungal disease in the critically ill patient is a serious complication that increases hospitalization times, morbidity and mortality, and healthcare costs.
- Trial name
- FPR-IIS (NCT04484376)
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Hospital Universitario La Fe
Acute Lymphoblastic Leukemia
Observational Study on Invasive Fungal Infection Incidence in Ph-neg Acute Lymphoblastic Leukemia Patients
Primary objective To document the occurrence of fungal infections during the early stages of chemotherapy (from onset to TP2, i.e., week 16) in adult Ph-neg ALL patients Secondary objectives To document the occurrence of IFI in…
- Trial name
- ALL-IFI (NCT06392581)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Mycobacterium Avium-Intracellulare Infection, HIV Infections
Evaluation of the Therapeutic Benefit of r-metHuIFN- Gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
To examine the effectiveness of subcutaneous gamma interferon in reducing severity of Mycobacterium avium- intracellulare (MAI) bacillemia episodes in AIDS patients in an open-label dose-randomized multi-center pilot clinical…
- Trial name
- NCT00002037
- Testing
- Trifluridine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Amgen
Candidiasis, Candidemia
Study of Micafungin in Patients With Invasive Candidiasis or Candidemia
The purpose of the study is to determine the safety and effectiveness of two dose levels of micafungin versus caspofungin in the treatment of proven invasive candidiasis or candidemia.
- Trial name
- NCT00105144
- Testing
- Micafungin, Caspofungin
- Where
- 167 sites in United States, Austria and 13 more
- Volunteers
- 611 people
- Sponsor
- Astellas Pharma Inc
Leukopenia
Safety and Efficacy Study of Posaconazole vs. Fluconazole for Prevention of Invasive Fungal Infection (P05387 AM1)(COMPLETED)
A randomized, open label parallel controlled, multicenter study to evaluate safety and efficacy of Posaconazole oral suspension vs Fluconazole (capsule) in high-risk leukopenic patients for prevention of invasive fungal infection
- Trial name
- NCT00811928
- Testing
- Posaconazole, Fluconazole
- Volunteers
- 252 people
- Sponsor
- Merck Sharp & Dohme LLC
Invasive Fungal Infections, Liposomal Amphotericin B
Population Pharmacokinetics of L-AmB in Chinese Patients Assisted by Extracorporeal Membrane Pulmonary Oxygenation (ECMO)
The goal of this study is to investigate the effects of ECMO-assisted therapy on L-AmB PK parameters in patients with critically ill patients of invasive fungal infections, and to determine the in vivo pharmacokinetic changes of…
- Trial name
- NCT06754436
- Testing
- Determination of blood drug concentration
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Anzhen Hospital
Mycobacterium Avium-intracellulare Infection, HIV Infections
Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048
Some people who have taken azithromycin to prevent MAC (Mycobacterium avium Complex, a bacterial infection common in HIV-infected persons) have been found to carry antibiotic-resistant bacteria (germs that grow despite the…
- Conditions
- Mycobacterium Avium-intracellulare Infection, HIV Infections, Pneumococcal Infections
- Trial name
- NCT00000933
- Where
- 15 sites in United States
- Volunteers
- 326 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)