Clinical trials: Distal Symmetric Polyneuropathy
Diabetic Peripheral Neuropathy
Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study
To determine if pulsed electric field therapy reduces lower leg and foot pain associated with diabetic neuropathy and lessens the need for medication.
- Trial name
- DPN (NCT00614341)
- Testing
- MedRelief SE 55
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- MedRelief
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation)
Thai PainPREDICT Validation Study
Painful diabetic neuropathy (PDN) is one of the most common and disabling complications of diabetes mellitus, substantially affecting quality of life, daily functioning, and health system burden.
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation), Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PainPREDICT-Th (NCT07195045)
- Testing
- Thai PainPREDICT Questionnaire and Mobile Application
- Where
- Thailand
- Volunteers
- 277 people
- Sponsor
- Chulalongkorn University
HIV, Non-HIV
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
The study team's prior research has shown that dysfunction of a specific nerve, called the vagus nerve, is associated with small intestinal bacterial overgrowth (SIBO), and that SIBO is associated with signs of inflammation in…
- Conditions
- HIV, Non-HIV, Vagus Nerve Dysfunction
- Trial name
- EVA (NCT04353778)
- Testing
- Pyridostigmine, non-invasive vagal nerve stimulation
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus, Painful Distal Symmetric Sensorimotor Polyneuropathy
Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy
The difference between active treatment and placebo in a clinical trial of an analgesic appears to depend on a variety of factors other than the actual efficacy of the drug itself, including various aspects of study design and…
- Trial name
- NCT01770964
- Testing
- Pregabalin, Training Type A, Training Type B
- Where
- 6 sites in United States
- Volunteers
- 90 people
- Sponsor
- Analgesic Solutions
Diabetic Neuropathy
Clinical Outcomes Related to Treatment of Distal Symmetric Polyneuropathy Using Semiconductor Embedded Therapeutic Socks
Distal symmetric polyneuropathy, also known as diabetic neuropathy, is the most common neurological complication of diabetes and a main cause of morbidity.
- Trial name
- NCT06452914
- Testing
- Semiconductor Embedded Therapeutic Socks
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Endocrine Research Solutions
HIV Infections, Distal Symmetric Polyneuropathy
ALCAR Prophylaxis Study
The purpose of this study is to determine whether Acetyl L-carnitine can prevent the development of nerve damage, known as neuropathy, in individuals taking anti-HIV drugs over a 48-week period.
- Trial name
- NCT00225160
- Testing
- acetyl L-carnitine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Royal Free Hampstead NHS Trust
Diabetic Distal Symmetric Polyneuropathy
Effects of Four-Cell Galvanic Therapy on Pain and Balance in Diabetic Peripheral Neuropathy
This study aims to evaluate the effects of four-cell galvanic bath therapy on pain and balance in patients with diabetic distal symmetric polyneuropathy.
- Trial name
- GABATH-DPN (NCT07590011)
- Testing
- Four-Cell Galvanic Bath Therapy, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara Etlik City Hospital
HIV Infections, Peripheral Nervous System Diseases
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to determine if an investigational drug, NGX-4010 (high-concentration capsaicin patch), is effective in treating painful HIV-associated neuropathy.
- Conditions
- HIV Infections, Peripheral Nervous System Diseases, Pain
- Trial name
- NCT00064623
- Testing
- Capsaicin Dermal Patch
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- NeurogesX
Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation)
Effect of Gluten-Free Dietary Education and Intraneural Facilitation® Therapy on Quality of Life in People With Diabetic Neuropathy
The purpose of this research is to compare the effectiveness of providing dietary education to complement Intraneural Facilitation® Therapy (INF® Therapy) (a physical therapy technique being evaluated that may help improve…
- Trial name
- NCT05165368
- Testing
- Intraneural Facilitation® Therapy (INF® Therapy), INF® Therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Loma Linda University
Distal Symmetric Polyneuropathy (DSPN)
Can Ultrasound Detect Diabetic Peripheral Neuropathy?
The cross sectional area of posterior tibial nerve (PTN) is increased in diabetic patients with distal symmetric polyneuropathy (DSPN) as compared to diabetic patients without DSPN.
- Trial name
- NCT01261442
- Testing
- Nerve Conduction Study (NCS)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
HIV Infections, Peripheral Nervous System Disease
Nerve Damage in Patients With HIV Infection Who Have Been Treated With Anti-HIV Drugs
The purpose of this study is to find out what might increase nerve damage in people with HIV who have taken drugs for treatment of HIV disease.
- Trial name
- NCT00017771
- Where
- 18 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetics
Efficacy and Safety Study of Thioctacid Oral Tablets 600mg to Treat Chinese Diabetic Patients With Distal Symmetric Polyneuropathy
The purpose of the study is to evaluate the efficacy on overall neuropathic sensory symptom improvement of Thioctacid tablet 600mg once daily vs.
- Trial name
- NCT01224353
- Testing
- lipoic acid
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- NovaMed Pharmaceuticals Inc.
Distal Symmetric Polyneuropathy (DSPN)
A Study To Evaluate the Safety, Tolerance, Pharmacokinetics/Pharmacodynamics and Efficacy of SYHA1402 Tablets For the Treatment of Patients With Diabetic Peripheral Neuropathy in China
This study aims to evaluate the safety, tolerance, pharmacokinetics/pharmacodynamics and efficacy of SYHA1402 tablets for the treatment of patients with diabetic peripheral neuropathy (DPN) in China.
- Trial name
- NCT05116111
- Testing
- SYHA1402 tablets
- Volunteers
- 135 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Type 2 Diabetes Mellitus
The Multi-Centric Clinical Study of Chinese Medicine Intervention on Diabetes Distal Symmetric Polyneuropathy.
Background: Distal symmetric polyneuropathy (DSPN) is the most common complication of type 2 diabetes mellitus (T2DM) and the most common form of peripheral neuropathy.
- Trial name
- NCT03010241
- Testing
- Tangbi (prescription)
- Volunteers
- 188 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Polyneuropathies, Obesity
Effect of Exercise and Surgical Weight Loss on Polyneuropathy
The purpose of this research study is to evaluate how exercise and surgical weight loss affect how likely an individual is to develop peripheral neuropathy and other neurologic complications.
- Conditions
- Polyneuropathies, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03617185
- Testing
- High Intensity Interval Training (HIIT), Routine Exercise, Bariatric surgery
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan