Clinical trials: Distress Due to COVID-19
COVID, Covid-19
A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19
The purpose of this study is to evaluate the safety and effectiveness of APL-9 in adults with mild to moderate ARDS (acute respiratory distress syndrome) caused by COVID-19 who are hospitalized and require supplemental oxygen…
- Conditions
- COVID, Covid-19, Coronavirus, Coronavirus Infection
- Trial name
- NCT04402060
- Testing
- APL-9, Vehicle Control
- Where
- 24 sites in United States, Brazil
- Volunteers
- 72 people
- Sponsor
- Apellis Pharmaceuticals, Inc.
COVID19
Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19
This study is a Phase 1, open label, non-randomized, two-arm interventional clinical trial to evaluate the safety and efficacy of Virazole® in hospitalized adult patients who have tested positive for COVID-19 and, as a result…
- Trial name
- NCT04551768
- Testing
- 50 mg/mL Virazole, 100 mg/mL Virazole
- Where
- 4 sites in Greece, Mexico
- Volunteers
- 51 people
- Sponsor
- Bausch Health Americas, Inc.
Acute Respiratory Distress Syndrome, COVID-19
PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia
This study aims to compare epidemiology, management of invasive ventilation and outcomes in critically ill patients with COVID-19 ARDS and ARDS from another pulmonary infection.
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19, Pneumonia, Mechanical Ventilation Complication
- Trial name
- PRoVENT-COP (NCT05650957)
- Where
- 6 sites in Argentina, Brazil and 3 more
- Volunteers
- 7,145 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Insufficiency
Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS).
- Trial name
- COVAQ (NCT05392062)
- Testing
- Pathophysiology of gas exchange
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
COVID19
Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19_#2
This study is a Phase 1, open label, non-randomized, two-arm interventional clinical trial to evaluate the safety and efficacy of Virazole® in hospitalized adult patients who have tested positive for COVID-19 and, as a result…
- Trial name
- NCT04356677
- Testing
- 50 mg/mL Virazole, 100 mg/mL Virazole
- Sponsor
- Bausch Health Americas, Inc.
COVID-19, Acute Respiratory Distress Syndrome
Umbilical Cord Tissue (UC) Derived Mesenchymal Stem Cells (MSCs) Versus Placebo to Treat Acute Pulmonary Inflammation Due to COVID-19
The purpose of this study is to demonstrate the safety of Umbilical Cord Tissue Derived Mesenchymal Stem Cells (UCMSCs) administered intravenously in patients with acute pulmonary inflammation due to COVID-19 with moderately…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Corona Virus Infection
- Trial name
- COVID-19 (NCT04490486)
- Testing
- UCMSCs
- Sponsor
- Joshua M Hare
COVID19, ARDS
REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia
To assess the safety and efficacy of CK0802 in treatment of patients with COVID-19 induced moderate-to-severe PNA-ARDS.
- Trial name
- RESOLVE (NCT04468971)
- Testing
- CK0802
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Cellenkos, Inc.
Psychological Distress
RESPOND: Improving the Preparedness of Health Systems to Reduce Mental Health and Psychosocial Concerns Resulting From the COVID-19 Pandemic
This randomized controlled trial will evaluate the implementation and (cost-)effectiveness of the culturally and contextually adapted Doing What Matters in times of stress (DWM) and Problem Management Plus (PM+) stepped-care…
- Trial name
- RESPOND (NCT04993534)
- Testing
- Stepped-care DWM/PM+, Psychological First Aid + usual care (CAU)
- Where
- Italy
- Volunteers
- 212 people
- Sponsor
- Universita di Verona
Covid19, Acute Respiratory Distress Syndrome
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
This is a pilot, multi-centre, open-label randomised controlled study to assess the early efficacy of intravenous (IV) administration of CYP-001 in adults admitted to an intensive care unit (ICU) with respiratory failure
- Trial name
- MEND (NCT04537351)
- Testing
- CYP-001
- Where
- 5 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Cynata Therapeutics Limited
2019 Novel Coronavirus Infection, COVID-19 Virus Infection
Safety and Efficacy of USB002 for Respiratory Distress Due to COVID-19
This trial will study the use of USB002 given as an intravenous infusion in patients with respiratory distress due to infection with COVID-19.
- Conditions
- 2019 Novel Coronavirus Infection, COVID-19 Virus Infection, SARS Coronavirus 2 Infection, SARS-CoV-2 Infection
- Trial name
- NCT04778059
- Testing
- USB002
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- US Biotest, Inc.
COVID-19 Acute Respiratory Distress Syndrome, Respiration, Artificial
Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19
Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV).
- Trial name
- VICAR (NCT04894214)
- Testing
- Arterial blood gas (ABG), Recording of hemodynamic monitoring, Recording of respiratory monitoring
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Hospital, Antwerp
Distress Due to COVID-19
Expressive Writing for COVID-19 Resilience
The purpose of this study is to determine the impact of a 6-week, virtually-delivered expressive writing intervention on resilience in a cohort of individuals currently navigating the COVID-19 pandemic during spring 2020.
- Trial name
- NCT04589104
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19
Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
The aim of this study is to characterize patients in the Post-Intensive-Care-Syndrome (PICS) outpatient clinic based on routine data and to evaluate their treatment outcome over the course of their treatment.
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19, Pregnancy Related
- Trial name
- NCT07051967
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19, Respiratory Insufficiency
Telmisartan in Respiratory Failure Due to COVID-19
Rationale: The renin-angiotensin-aldosterone system (RAAS) dysregulation may play a central role in the pathophysiology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection associated acute lung injury (ALI)…
- Conditions
- COVID-19, Respiratory Insufficiency, Telmisartan, Respiratory Distress Syndrome, Adult
- Trial name
- STAR-COVID (NCT04510662)
- Testing
- Telmisartan
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Abraham Edgar Gracia-Ramos
COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication
Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19
Many questions about management of COVID-19 are still not answered. So, we recruit this study aiming to evaluate improvement of oxygenation in COVID-19 patients with severe ARDS, to improve morbidity and mortality of ICU covid…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication, ICU Acquired Weakness
- Trial name
- NCT04922814
- Testing
- muscle relaxation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
ARDS Due to COVID-19
Surfactant-BL in Adult Acute Respiratory Distress Syndrome Due to COVID-19
The purpose of this study is to prove the efficacy and safety Surfactant-BL, administered by inhalation in adult hospitalized patients with ARDS due to COVID-19.
- Trial name
- NCT04568018
- Testing
- Surfactant
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Biosurf LLC.
Respiratory Mechanics, Respiration, Artificial
Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19
Research question: Are the ventilatory variables related to mechanical power associated with the outcome of subjects who received mechanical ventilation (MV) for Acute Respiratory Distress Syndrome (ARDS) secondary to pneumonia…
- Conditions
- Respiratory Mechanics, Respiration, Artificial, Respiratory Distress Syndrome
- Trial name
- NCT05946525
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Hospital Donación Francisco Santojanni
Acute Respiratory Distress Syndrome Due to SARS-CoV-2 Infection (Severe COVID19)
A Study of the C3 Inhibitor AMY-101 in Patients With ARDS Due to COVID-19 (SAVE)
The study is a prospective, randomized, placebo-controlled, single-blind phase 2 clinical study of the efficacy and safety of AMY-101, a potent C3 inhibitor, for the management of patients with ARDS caused by SARS-CoV-2…
- Trial name
- SAVE (NCT04395456)
- Testing
- AMY-101, WFI 5% glucose
- Volunteers
- 144 people
- Sponsor
- Amyndas Pharmaceuticals S.A.
Psychological Disease
RinasciMENTE, An Internet-Based Self-Help Intervention for People With Psychological Distress Due to COVID-19
This study aims is the evaluation of the efficacy and feasibility of RinasciMENTE, the Randomized Controlled Clinical Trial compared with a waiting list control group.
- Trial name
- NCT04907903
- Testing
- internet-based intervention
- Volunteers
- 128 people
- Sponsor
- Catholic University of the Sacred Heart
Covid19, ARDS
Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status
In this study, the investigators are attempting to evaluate the influence of socio-economic factors on the functional recovery (physical and psychological) of patients who developed ARDS after a COVID-19 infection, with the aim…
- Conditions
- Covid19, ARDS, Functional Recovery
- Trial name
- RECOVIDS (NCT04556513)
- Testing
- Paraclinical examination, Clinical Examination, Semi-directive interview
- Where
- France
- Volunteers
- 543 people
- Sponsor
- Centre Hospitalier Universitaire Dijon