Clinical trials: Diving
Immersion Pulmonary Edema (IPE), Swimming Induced Pulmonary Edema (SIPE)
Prevention and Treatment of Immersion Pulmonary Edema
Immersion pulmonary edema (IPE) is a condition in which fluid fills the lungs during diving or swimming, particularly in cold water. Some individuals appear to be predisposed to developing IPE.
- Trial name
- NCT00815646
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Oxygen Toxicity
Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 2)
The purpose of this study is to understand how ketogenic food products affect oxygen toxicity in undersea divers. Oxygen toxicity affecting the central nervous system, mainly the brain, is a result of breathing higher than normal…
- Trial name
- NCT05831228
- Testing
- Ketogenic food products
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Amateur Divers
Effects of Voluntary Neck Extension on Cerebral Blood Flow, in Breath-hold Divers Ending an Apnoea of Two Minutes or More.
The aim of this study is to demonstrate the effect of the voluntary neck extension in the occurrence of an increase in the pulsatility index of the right internal carotid artery in the amateur diver, realizing an apnea of two…
- Trial name
- APNECK (NCT03210857)
- Testing
- apnea performing
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Edema, Pulmonary, Immersion
Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention
This trial is testing the effectiveness of a single oral dose of sildenafil (50 mg) taken 1 hour before a provocative event on the subsequent development of swimming-induced pulmonary edema.
- Conditions
- Edema, Pulmonary, Immersion, Diving
- Trial name
- NCT03686813
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Volunteers
Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving
Antihistamines are commonly used and currently levocetirizine is most frequently prescribed in the Netherlands. They are commonly used by divers, to solve ear, nose and throat problems, especially to open tubal passage.
- Trial name
- NCT01496911
- Testing
- Levocetirizine, Hydroxyzine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Oxygen Toxicity
Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)
The purpose of this study is to understand how ketogenic food products affect oxygen toxicity in undersea divers. Oxygen toxicity affecting the central nervous system, mainly the brain, is a result of breathing higher than normal…
- Trial name
- NCT05801120
- Testing
- Ketogenic food products
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Duke University
Middle-ear Barotrauma
Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation
This study will determine if newly developed and more standard tests of Eustachian tube function can identify those persons who have ear pain (barotrauma) or develop middle-ear inflammation and/or fluid (barotitis) when they are…
- Trial name
- NCT01976429
- Testing
- flight/diving simulation, ET function testing at ambient pressure, nasal video-endoscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sport Physiology, Cognitive Performance
Cognitive Responses to Acute Breath-Hold Diving Training in Female Divers
This study aims to investigate the acute cognitive and physiological responses to breath-hold diving training in trained female divers.
- Trial name
- NCT07616804
- Testing
- Land-Based Breath-Hold Training, Water-Based Breath-Hold Training, Control Session
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Hyperbaric, Diving Medicine
Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air
Primary objective: Assessment of venous gas emboli load post diving when breathing normobaric oxygen compared to air. Secondary objective: Assessment of fluid markers of central nervous system injury in blood post diving…
- Conditions
- Hyperbaric, Diving Medicine, Decompression Sickness, Central Nervous Injury
- Trial name
- NCT02468752
- Testing
- Oxygen, Air
- Where
- 2 sites in Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Decompression Sickness, Endothelial Dysfunction
Exercise and Repetitive Diving
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.
- Conditions
- Decompression Sickness, Endothelial Dysfunction, Neutrophil Activation, Venous Gas Emboli
- Trial name
- NCT02118207
- Testing
- Aerobic running exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Split