Clinical trials: Dobutamine
Sepsis, Cardiomyopathies
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion
Sepsis induces both a systolic and diastolic cardiac dysfunction. The prevalence of this septic cardiomyopathy ranges between 30 and 60% according to the timing of assessment and definition used.
- Conditions
- Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction
- Trial name
- ADAPT (NCT04166331)
- Testing
- Dobutamine
- Where
- 21 sites in France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges
Acute Myocardial Infarction, Cardiogenic Shock
Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock
In the present study, we aim to investigate the effects of dobutamine infusion and/or a single intravenous (IV) dose of the IL-6 antagonist Tocilizumab administered after percutaneous coronary intervention (PCI) to patients with…
- Trial name
- DOBERMANN (NCT05350592)
- Testing
- Tocilizumab, Dobutamine, NaCl 0.9%
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fractional Flow Reserve
DSE vs Invasive FFR vs CT-FFR
Data are limited regarding the optimal treatment of the non-culprit lesions (NCL) after myocardial infarction (MI). The NON-CULPRIT study is a prospective cohort study with a primary aim to compare invasive fractional flow…
- Trial name
- NON-CULPRIT (NCT03988881)
- Testing
- Revascularization
- Where
- 2 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Heart Failure
Dobutamine Stress Echocardiography in Cardiac Resynchronization Therapy (CRT) Patients Selection
While cardiac resynchronization therapy (CRT) has a well demonstrated therapeutic effect in selected patients with advanced heart failure (HF) on optimized drug therapy, non-responder rate remains high.
- Trial name
- LODO-CRT (NCT00828360)
- Where
- 5 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Ospedale Santa Maria di Loreto Mare
Coronary Disease
Comparison of Echocardiographic Techniques in Diagnosis of Coronary Artery Disease
This study is designed to compare two different echocardiographic techniques in the evaluation of heart disease (coronary artery disease).
- Trial name
- NCT00001889
- Testing
- Myocardial contrast echocardiography, Stress echocardiography with dobutamine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Three-dimensional Assessment of Intraventricular Dyssynchrony Using Fast Dobutamine Gated SPECT
The prognosis of patients with heart failure has improved due to recent breakthrough in medical treatment and cardiac resynchronization devices.
- Trial name
- FAST DOGS (NCT02510677)
- Testing
- myocardial perfusion scintigraphy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Caen
Mortality After Major Non Cardiac Surgery
Intraoperative Dobutamine Stress Test With Speckle Tracking to Decrease Postoperative Mortality (ISTMO)
Perioperative adverse cardiovascular events are the leading cause of morbidity and mortality after noncardiac surgery. The implications of perioperative cardiac complications on morbidity and mortality, in-hospital and long-term…
- Trial name
- ISTMO (NCT03365726)
- Testing
- Dobutamine stress test with trans-esophageal echocardiography
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cirrhosis, Cirrhotic Cardiomyopathy
DOCICAR: Cardiac Dysfunction in Cirrhosis
Patients with cirrhosis have a altered cardiac response to stress. This study evaluate the cardiac response by MRI during dobutamine stress. Hypothesis: impared increase in cardiac output, cardiac index, ejection fraction.
- Trial name
- NCT00250315
- Testing
- Dobutamine
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Aortic Valve Stenosis, Valvular Stenosis
Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
When aortic valve-area is <1.0cm2 and transvalvular mean-gradient is >40mmHg, the diagnosis of severe aortic stenosis (AS) is straightforward.
- Conditions
- Aortic Valve Stenosis, Valvular Stenosis, Valvular Heart Disease
- Trial name
- DALLAS (NCT05015829)
- Testing
- Dobutamine Stress Echocardiography
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease
Dobutamine Stress Cardiac Magnetic Resonance Versus Echocardiography for the Assessment of Outcome. Are the Two Imaging Modalities Comparable?
Dobutamine stress echocardiography (DSE) and cardiac magnetic resonance (DCMR) are both established non-invasive techniques, used in the clinical routine for the diagnostic classification and risk stratification of patients with…
- Trial name
- NCT01568502
- Where
- Germany
- Volunteers
- 5,008 people
- Sponsor
- University Hospital Heidelberg
Ischemic Heart Disease
DSE vs. FFR in SCAD and BYSTANDER Lesions
Enrollment: Patients with stable coronary artery disease (SCAD) and moderate coronary artery stenoses (30-70 %) Patients with acute myocardial infarction and moderate stenosis of non-culprit arteries (NCL; BYSTANDER LESION) Aims…
- Trial name
- DSE-vs-FFR (NCT03383718)
- Testing
- Revascularisation, Optimal Medical Treatment/OMT
- Volunteers
- 200 people
- Sponsor
- Bajcsy-Zsilinszky Hospital
Peripheral Arterial Disease
Non-invasive Cardiac Screening in High Risk Patients -The GROUND Study
The purpose of this study is to find out if subjecting cardiac high risk patients to non invasive cardiac imaging, followed by treatment will improve survival and quality of life
- Trial name
- NCT00189111
- Testing
- Cardiac Imaging + Treatment
- Where
- 5 sites in Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Clinical Research Office Imaging Division
Heart Failure
Right Ventricular Contractile Reserve in HF
Right ventricle dysfunction and pulmonary hypertension are related to a worse prognosis in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) or with normal left ventricular ejection fraction…
- Trial name
- RISE-HF (NCT05797584)
- Testing
- Dobutamine, Passive leg raising
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Heart Failure, Congestive
A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failure
The purpose of this study is to compare the effects on heart rate and ventricular arrhythmias (irregular heart beats) of two doses of Natrecor® (a recombinant form of the natural human peptide normally secreted by the heart in…
- Trial name
- NCT00270400
- Testing
- nesiritide
- Volunteers
- 255 people
- Sponsor
- Scios, Inc.
Septic Shock
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at…
- Trial name
- NCT01271153
- Testing
- Dobutamine
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Coronary Artery Disease (CAD)
Prognostic Value of High Dose Dobutamine Stress Magnetic Resonance Imaging
High-dose dobutamine/atropine stress cardiac magnetic resonance imaging (DS-MRI) has been incorporated in daily clinical practice for the detection of ischemic heart disease.
- Trial name
- DS-Prognosis (NCT00837005)
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- Heidelberg University
Coronary Disease
Myocardial Perfusion, Coronary Flow Reserve and Kinetic Analysis During Dobutamine Stress Echocardiography
Stress echocardiography is a screening test for coronary heart disease that already has good sensitivity and specificity (both around 70%).
- Trial name
- TRIPLESTRESS (NCT03996499)
- Testing
- Stress echocardiography
- Where
- France
- Volunteers
- 201 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Diabetes Complications, Vitamin D Deficiency
Myocardial Function and Vitamin D Supplementation in Diabetes.
Vitamin D deficiency is recognized as a cardiovascular risk factor. Diabetic patients are of major risk for cardiovascular diseases and typically present with Vitamin D deficiencies.
- Conditions
- Diabetes Complications, Vitamin D Deficiency, Vitamin D Supplementation, Myocardial Dysfunction
- Trial name
- VitaDD (NCT03437421)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University of Avignon
Ischemic Cardiomyopathy
Stress Cardiac MRI in Ischemic Patients
The aim of this study is to assess the diagnostic accuracy of CMR feature-tracking (FT) at rest \& during stress with low dose dobutamine (LDD) in the evaluation of viability in ischemic cardiomyopathy (ICM) patients and compare…
- Trial name
- NCT04588675
- Testing
- MRI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University