Clinical trials: Dobutamine
Aortic Valve Stenosis
Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve…
- Trial name
- LOWAS (NCT02727504)
- Testing
- Electrocardiogram, 2D and 3D echocardiography, Dobutamine stress echocardiography
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Rennes University Hospital
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Intraoperative Myocardial Depression
Dobutamine During Major Abdominal Surgery
The PUSH-1 trial is a randomized, single-center pilot trial investigating whether dobutamine administration is feasible in patients having major abdominal surgery.
- Trial name
- PUSH-1 (NCT07000994)
- Testing
- Dobutamine, Routine care
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Hamburg-Eppendorf
Hypertrophic Obstructive Cardiomyopathy
Quantitative Assessment of Hypertrophic Obstructive Cardiomyopathy With Intraoperative Three-dimensional Transesophageal Echocardiography Under Provocative Dobutamine Stress Test
The objectives of this study are to determine if the left ventricle outflow tract (LVOT) gradients may be reproduced with dobutamine (DBT) provocation test in obstructive HCM patients under general anesthesia and to analyze the…
- Trial name
- NCT05025644
- Testing
- Pre and post-CPB Drug: Dobutamine Hydrochloride, Post-CPB Drug: Dobutamine Hydrochloride
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Diabetes-related Complications
Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes
Summary. Theoretical Rationale: The left ventricular myocardial performance results from a complex interplay between linear deformations (longitudinal, circumferential and radial) and twist/ untwist mechanics.
- Trial name
- NCT02505451
- Testing
- dobutamine
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Acute Decompensated Heart Failure
A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide (rhBNP) with dobutamine on acute decompensated heart failure patients with different blood BNP levels
- Trial name
- NCT01837849
- Volunteers
- 104 people
- Sponsor
- Nantong University
Perioperative Tissue Oxygenation
Improving Tissue Oxygenation in Breast Reconstruction Surgery
Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue).
- Trial name
- NCT04020172
- Testing
- Dobutamine
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD)
End-Stage Renal Disease, Cardiovascular Diseases
Myocardial Perfusion and Contractile Reserve in End-stage Renal Disease
The investigators prospectively recruited a total of 377 ESRD patients evaluated for kidney transplantation between January 2010 and July 2013 in our centre.
- Trial name
- NCT04172064
- Testing
- Myocardial perfusion scintigraphy
- Volunteers
- 377 people
- Sponsor
- University Hospital Muenster
Cardiac Complications of Care (& [Post Operative])
Prognostic Accuracy of Coronary CT and Dobutamine Stress Echocardiography in Patient Undergoing Non-cardiac Surgery
This study aimed to compare dobutamine stress echocardiography (DES) with computed tomography coronary angiography (CTCA) in patients with undergoing intermediate to high risk noncardiac surgery.
- Trial name
- NCT02250963
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Gyeongsang National University Hospital
Cardiovascular Diseases
Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac Surgery
This study wants to investigate the hemodynamic changes in cardiopatic patients undergoing major non cardiac surgery, during and after the continuous infusion of levosimendan or dobutamine.
- Trial name
- NCT02012946
- Testing
- Levosimendan, Dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Policlinico Umberto I
Sepsis, Hypoperfusion
Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.
This phase 2 study aim to investigate the effect of dobutamine in patients with sepsis/ septic shock after fluid resuscitation and with hypoperfusion (lactate and central venous oxygen saturation or prolonged capillary refill…
- Conditions
- Sepsis, Hypoperfusion, Hyperlactatemia
- Trial name
- DEEP (NCT05953142)
- Testing
- Dobutamine
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Infant, Premature, Diseases, Circulatory and Respiratory Physiological Phenomena
Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants
Single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (SVC) flow, in infants below 33 weeks' gestation during…
- Trial name
- NeoCirc-002 (NCT06878742)
- Testing
- Intravenous dobutamine 5 mcg/kg/min, Intravenous dobutamine 7.5 mcg/kg/min, Intravenous dobutamine 10 mcg/kg/min
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cardiac Output, Low, Coronary Disease
Liberal Versus Restrictive Use of Dobutamine in Cardiac Surgery
Inotropic agents are usually administered in the postoperative period after cardiac surgery. In most cases, dobutamine is administered routinely, for the probable occurrence of myocardial dysfunction after cardiopulmonary bypass…
- Trial name
- DOBUTACS (NCT02361801)
- Testing
- Liberal dobutamine protocol, Restrictive dobutamine protocol
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo
Heart Failure, Cardiogenic Shock
Effect of Ivabradine in Stage D HF/Cardiogenic Shock Patients on Dobutamine
This is a randomized, double blind, single center trial to study of the effects of Ivabradine vs. Placebo on patients hospitalized for Stage D heart failure (HF)/ and cardiogenic shock (CS) who will require continuous infusion of…
- Conditions
- Heart Failure, Cardiogenic Shock, Tachycardia
- Trial name
- NCT03387605
- Testing
- Ivabradine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Loyola University
Cardiovascular Diseases, Coronary Disease
Dobutamine Echocardiography In Patients With Ischemic Heart Failure Evaluated for Revascularization
To define the role of the assessment of myocardial viability with dobutamine echocardiography (DE) in the clinical evaluation and selection of the best treatment for a high-risk subset of patients with coronary artery disease.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Heart Failure, Congestive
- Trial name
- DECIPHER (NCT00074724)
- Testing
- Coronary Artery Bypass, Modern medical management, Dobutamine echocardiography
- Volunteers
- 319 people
- Sponsor
- Medstar Health Research Institute
Coronary Artery Disease, Chest Pain
Artificial Intelligence Stress Echo (FINESSE) Project
The goal of this observational study is to learn whether combining stress echocardiography (stress echo) results with routine clinical information can better predict important heart outcomes in adults (18+) with chest pain who…
- Conditions
- Coronary Artery Disease, Chest Pain, Myocardial Ischemia, Angina Pectoris
- Trial name
- FINESSE (NCT07432620)
- Testing
- Dobutamine Stress Echocardiography
- Where
- United Kingdom
- Volunteers
- 2,281 people
- Sponsor
- Milton Keynes University Hospital NHS Foundation Trust