Clinical trials: Dopamine
Parkinson Disease, Parkinsonism
Non-motor Symptoms and Brain Dopamine Transporter Binding
This project aims to clarify the role non-motor symptoms in the development of Parkinson's disease (PD) and to improve diagnostics at very early stages of PD.
- Trial name
- NMDAT (NCT02650843)
- Testing
- DAT SPECT imaging
- Volunteers
- 455 people
- Sponsor
- Turku University Hospital
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Emotions
Emotions, Dopamine, Brain and Body
The study will examine the influence of domperidon (20mg) on brain and hebavioral responses to emotional stimuli (videos) using fMRI
- Trial name
- EMBODY (NCT06171087)
- Testing
- Domperidon
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Anorexia Nervosa
PET Imaging Study of Recovered Anorexics
Several studies in the past suggest that individuals who have or had anorexia nervosa may have alterations in brain serotonin. Serotonin seems to play an important role in regulating anxiety, mood, and other symptoms found in…
- Trial name
- NCT00603018
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Fluid Refractory Septic Shock, Septic Shock
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children.
- Trial name
- NCT07273526
- Testing
- Adrenaline, Dopamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Laiba Qamar
Healthy
The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study
The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach.
- Trial name
- NCT02801643
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Major Depressive Disorder
Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)
This study was a single-arm, open-label clinical study to assess dopamine transporter occupancy in the brain of patients with depression using 11C-CFT positron emission tomography (PET).
- Trial name
- NCT06026917
- Testing
- Toludesvenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Mental Health Center
Dementia With Lewy Bodies, Alzheimer's Disease
A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET)
The purpose of this study is to evaluate the ability to identify individuals with dopaminergic degeneration in group of patients with a clinical diagnosis of either dementia with Lewy bodies (DLB) or idiopathic Parkinson's…
- Conditions
- Dementia With Lewy Bodies, Alzheimer's Disease, Parkinson's Disease
- Trial name
- NCT01503944
- Testing
- 18F-AV-133, 18F-AV-45
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Parkinson Disease (PD)
The Safety, Feasibility and Efficacy of NouvNeu001 for Parkinson's Disease
This clinical trial is designed to evaluate the safety, tolerability and preliminary efficacy of a single injection of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in patients with Parkinson's disease.
- Trial name
- NCT07028632
- Testing
- Human Dopaminergic Progenitor Cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- iRegene Therapeutics Co., Ltd.
Depression
Mechanisms Underlying Antidepressant Effects of Physical Activity
It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect.
- Trial name
- LIFE (NCT06387732)
- Testing
- Aerobic exercise, Stretching and relaxation
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University College, London
Erectile Dysfunctions, Healthy Volunteer
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Viaca (Sildenafil + Cabergoline) Compared With Sildenafil and Cabergoline
This is a Phase 1, open-label, single-ascending-dose study evaluating the safety, tolerability, and pharmacokinetics (PK) of Viaca - a fixed-dose oral combination of sildenafil (a PDE5 inhibitor) and cabergoline (a dopamine D2…
- Trial name
- NCT07732387
- Testing
- Viaca, Sildenafil 50 mg, Cabergoline 0.5 MG
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yanping Kong
Nausea and Vomiting, Nausea
Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide
The study team proposes a double-blind, comparative effectiveness, randomized controlled trial (RCT) to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the…
- Conditions
- Nausea and Vomiting, Nausea, Vomiting
- Trial name
- BARF RCT (NCT06740812)
- Testing
- Fosaprepitant for Injection, Metoclopramide Injection
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Montefiore Medical Center
Clear Cell Renal Cell Carcinoma
Diagnostic Imaging for Clear Cell Renal Cell Carcinoma
The main objective is to study whether imaging detection of the biomarker DAT can be used to detect kidney tumors identified by computer tomography (CT), which are pathologically assesses as being of the clear cell subtype.
- Trial name
- RCCSCAN (NCT03185182)
- Testing
- Ioflupane I123
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Region Skane
Cocaine Use Disorder
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD).
- Trial name
- NCT05011760
- Testing
- Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rajesh Narendran
Stimulant Use Disorder
Repetitive Transcranial Magnetic Stimulation Treatment of Stimulant Use Disorder
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD).
- Trial name
- VA-StARTS (NCT07112105)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- VA Office of Research and Development
Fatigue, Iron-deficiency
Effect of Iron on Cerebral Dopamine Receptor Density in Non-anaemic Premenopausal Women With Low Ferritin and Fatigue
This study investigates the effect of intravenous iron substitution in non-anaemic premenopausal women with iron deficiency on: Changes in the cerebral Dopamine (DA) receptor density after iron substitution, shown by brain PET…
- Trial name
- NCT03305705
- Testing
- Iron Carboxymaltose, Sodium chloride 0.9%
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Albina Nowak, MD
Parkinson Disease
Effect of Dopamine on Specific Processing of Shame and Embarrassment in Parkinson's Disease
Shame and embarrassment are two self-conscious emotions frequently experienced by Parkinson's disease (PD) patients. Shame and embarrassment scores strongly correlate with patient's quality of life, anxiety and depression…
- Trial name
- BioDopa (NCT06225869)
- Testing
- Assessments in ON and OFF levodopa state
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Child Development, Child Behavioral Problems
LOVING (Learning About Our Behavior is Valuable for Increasing Nurturing Relationships and Healthy Growth) RCT
The LOVING study is a randomized controlled trial designed to determine whether adaptations to an internationally recognized parenting program that enhances sensitive caregiving likewise improves sensitive caregiving in Singapore…
- Conditions
- Child Development, Child Behavioral Problems, Parent Child Relationship
- Trial name
- LOVING (NCT07687524)
- Testing
- VIPP-SD-SingH, "Video-Feedback Intervention to Promote Positive Parenting and Sensitive Discipline Adapted for the Singapore Context with a Health Component", CARE-SD, "Caregiver Awareness of Relationships through E-learning for Sensitivity and Discipline", NeuroEducation for Parents
- Where
- 5 sites in Singapore
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy Volunteer
A Study of the Ability of Functional Magnetic Resonance Imaging (fMRI) to Detect and Characterize the Effects of Two Marketed Centrally Active Drugs, Placebo, and RO4917523 in Healthy Volunteers
This is an exploratory study to evaluate the usefulness of fMRI as a biomarker to characterize the response to three centrally active drugs and placebo.
- Trial name
- NCT01045083
- Testing
- RO4917523, escitalopram, methylphenidate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Parkinson's Disease, Dyskinesias
ACP-103 to Treat Parkinson's Disease
This study will evaluate the effects of an experimental drug called ACP-103 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term levodopa treatment.
- Trial name
- NCT00086294
- Testing
- Intravenous Levodopa, ACP-103
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)