Clinical trials: Drug Application
Chronic Heart Failure, Non-ischemic Cardiomyopathy
The Application of the Umbilical Cord Mesenchymal Stem Cells in the Complex Treatment of Non-ischemic Heart Failure
The purpose of this prospective single-arm clinical study was to evaluate the safety and potential efficacy of intracoronary administration of allogeneic umbilical cord-derived mesenchymal stromal cells (MSCs) as an addition to…
- Conditions
- Chronic Heart Failure, Non-ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RegenHeart (NCT04325594)
- Testing
- Intracoronary administration of umbilical cord-derived MSCs
- Where
- Kazakhstan
- Volunteers
- 30 people
- Sponsor
- The Research-Clinical Center for Cardiac Surgery and Transplantology LLP
Dental Implants , Osseointegration , Marginal Bone Loss , Implant Stability
Effect of Locally Applied Simvastatin Gel on Dental Implant Stability and Marginal Bone Level
stability and marginal bone level. Forty-two patients received dental implants and were randomly assigned to two groups. In the test group, 1.2% simvastatin in 4% methylcellulose gel was applied around the implant, while in the…
- Trial name
- NCT07194447
- Testing
- Simvastatin Gel, Methylcellulose Gel
- Where
- Iraq
- Volunteers
- 42 people
- Sponsor
- Maha Zuhair
Huntington Disease
Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington's Disease
Cellavita HD is a stem-cell therapy for Huntington's Disease. This is a first-in-human, non-randomized, phase I study in which participants with Huntington's Disease will receive three intravenous injections and will be followed…
- Trial name
- SAVE-DH (NCT02728115)
- Testing
- Cellavita HD Lower Dose, Cellavita HD Higher dose
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Azidus Brasil
Tracheal Intubation, Medical Education
Application of PDCA Cycle in Tracheal Intubation Training for Emergency Medicine Residents
Tracheal intubation is a critical but technically demanding procedure in emergency airway management. Junior emergency medicine residents often struggle to achieve proficiency, leading to increased risks of complications.
- Trial name
- PACT (NCT07146984)
- Testing
- Behavioral (Educational Training Program)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Panyu Central Hospital
Eyebrow Growth
Effects of CosmeRNA Brow Revitalizing Serum on Eyebrow Density and Length
This study evaluated the effects of CosmeRNA Brow Revitalizing Serum on eyebrow density and length in healthy Korean adults. Each participant applied the investigational serum to one eyebrow and a control serum to the other…
- Trial name
- NCT07819721
- Testing
- Eyebrow serum containing SDS-DNA-2/RNA-6, Control eyebrow serum without SDS-DNA-2/RNA-6
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- BIONEER Corporation
Lung Cancers
⁶⁸Ga-DPA in the Lung Cancer Diagnosis
In previous studies, we synthesized a PD-L1-targeted molecular probe, ⁶⁸Ga-DPA, and developed a ⁶⁸Ga-DPA injection for clinical research.
- Trial name
- NCT07023068
- Testing
- 68Ga-DPA PET/CT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Diabetes
Empowerment-based Complementary and Alternative Medicine (ECAM)
This phase study will use a randomized trial method to evaluate the performance of the ECAM educational app in the promotion of CAM health literacy and communication among patients with diabetes.
- Trial name
- CAM (NCT06317584)
- Testing
- Experimental: Empowerment Application for CAM Health Education, Written Paper for CAM Health Education
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- Chang Gung University of Science and Technology
HIV Infections
Study of Tenofovir Disoproxil Fumarate (TDF) for Prevention of HIV
This Phase 2 study involving tenofovir disoproxil fumarate (TDF) will assess the extended safety of TDF 300 mg per day among young women who are not HIV-infected.
- Trial name
- NCT00122486
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- 3 sites in Cameroon, Ghana and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- FHI 360
Cerebral Palsy, Mental Retardation
Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models
Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood…
- Conditions
- Cerebral Palsy, Mental Retardation, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT06848959
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Yun Liu,PhD
Respiratory Disease
The Efficiency of Chest Physiotherapy Applied in a Different Order
This study intends to compare the impact of chest physiotherapy applied with two different methods on physiologic parameters in children hospitalized in the intensive care unit.
- Trial name
- NCT05022082
- Testing
- Chest Physiotherapy- Aspiration- Inhaler drugs group
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Selmin Kose
Obesity, Abdominal Obesity
Application of the SIMPLE Program for Weight Loss at Pathways to Housing: A Feasibility Study
The objective of this study is to assess feasibility of the application of an adapted version, with permission, of Dr. Cenk Tek's Simplified Intervention to Modify Physical activity, Lifestyle, and Eating behavior (SIMPLE…
- Trial name
- NCT03389425
- Testing
- simplified intervention to modify physical activity, lifestyle, and eating behavior
- Volunteers
- 9 people
- Sponsor
- University of Calgary
Alzheimer Disease, Dementia
A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population
This is a bridging study to visually and quantitatively assess PET images obtained after single application of 300 MBq [18F]florbetaben and PET scanning of patients with Alzheimer disease.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05527288
- Testing
- Drug: [18F]florbetaben
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Healthy
An Open Study of the Safety and Pharmacokinetics of a Medicinal Product for Emergency Prevention of Ebola
This Phase I clinical trial was developed to study drug safety, tolerability, and pharmacokinetics of the medicine for Ebola fever emergency prevention based on monoclonal recombinant antibodies in single use in healthy…
- Trial name
- 03-AT-2017 (NCT03428347)
- Testing
- GamEMab
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Breast Neoplasms, Medication Adherence
A Novel E-Health Approach in Optimizing Treatment for Seniors (OPTIMUM Study)
Background: In women with hormone receptor positive (HR+) breast cancer, adjuvant endocrine therapy (AET) is associated with a significant survival advantage.
- Trial name
- NCT02876848
- Testing
- OPTIMUM e-health tool
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sinus Arrhythmia, Atrial Fibrillation
Electrophysiologically Guided PAcing Site Selection Study
This study is a long-term, prospective, and controlled evaluation of the incidence of persistent atrial fibrillation (AF) in patients with severe intra-right atrial conduction delay paced with preventive algorithms at the…
- Trial name
- EPASS (NCT00239226)
- Testing
- IAS pacing - study group, IAS pacing control group, Pacing RAA study group
- Where
- 8 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Medtronic BRC
Epistaxis
Effect of Practical Demonstration to Use Nasal Spray and Apply Intranasal Ointment on Epistaxis
To compare the result of verbally educating the parents about method of intranasal antiseptic cream application versus practically educating and demonstrating how to apply cream intra nasally.
- Trial name
- NCT04217941
- Testing
- Health education with practical demonstration of nasal ointment, Health Education and practical demonstration of Nasal spray and intranasal ointment
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Combined Military Hospital, Pakistan
COPD, Spirometry
Evaluation of a Mobile Application to Facilitate the Interpretation of Spirometry by Family Physicians and Residents
Problematic: Spirometry is used to objectify the obstructive syndrome defining chronic obstructive pulmonary disease (COPD). However, this test remains underused in the primary care.
- Conditions
- COPD, Spirometry, Mobile Application
- Trial name
- NCT03206606
- Testing
- SPIRO
- Where
- 8 sites in Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Laval University
Postoperative Ileus
The Effect of Acupoint Application on Postoperative Ileus
This study aims to verify the therapeutical effect and mechanism of acupoint application on postoperative ileus.
- Trial name
- NCT04008667
- Testing
- Acupoint application, Fake acupoint application
- Where
- China
- Volunteers
- 540 people
- Sponsor
- li xiong
Locally Advanced Thyroid Gland Carcinoma, Thyroid Cancer
Efficacy of Organoid-Based Chemotherapy Drug Precision Screening to Guide Treatment for Thyroid Cancer
The current study aims to explore the potential advantages of chemotherapy that is implemented based on drug sensitivity testing.
- Trial name
- NCT06713057
- Testing
- Cyclophosphamide+Pemetrexed+5-Fluorouracil, Cyclophosphamide+Doxorubicin+5-Fluorouracil, Vindesine + Cisplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Rotator Cuff Tear
Study on the Application of Shock Wave Technique After Rotator Cuff Operation
This study is a prospective cohort study and is a single-center clinical trial. The subjects of this study were patients who underwent rotator cuff repair in the Department of Sports Medicine and the Department of Rehabilitation…
- Trial name
- NCT06563739
- Testing
- Divergent low energy shock wave, Divergent medium and low energy shock wave, Focused low energy shock wave
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital