Clinical trials: Drug Application
Psoriasis
Phase I Study of GN-037 Cream for Psoriasis
In this Phase I study, three different doses (low, medium and high dose, on the basis of surface area applied) of GN-037 cream (12 volunteers in total) and placebo (6 volunteers in total) will be administered to healthy…
- Trial name
- NCT05428202
- Testing
- GN037
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
mNGS
mNGS Was Applied to the Study of Pathogen Identification, Precision Medication and Efficacy Evaluation of Infected Patients
1) prospectively collected the patients with the proposed infection, confirmed the infection or excluded the infection through mNGS detection combined with traditional pathogen detection methods and clinical characteristics…
- Trial name
- NCT04310657
- Testing
- mNGS
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Perception of Clinical Pharmacy Practice
Perceptions of Healthcare Professionals Toward Clinical Pharmacy Practice in Egypt
This study aims to explore how healthcare professionals in Egypt perceive the role of clinical pharmacists within hospital practice.
- Trial name
- NCT07248150
- Testing
- Survey Questionnaire
- Where
- Egypt
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pancreas-Kidney Transplantation
Simultaneous Pancreas-kidney Transplantation With Campath Protocol
The purpose of this study is to determine and compare the efficacy of Campath-1H/Tacrolimus versus ATG/Tacrolimus/MMF therapy in conjunction with initial short-term steroids in Type 1-diabetic patients undergoing simultaneous…
- Trial name
- NCT00316810
- Testing
- Alemtuzumab, Rabbit Anti-Human Thymocyte Globulin
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Dr. Claudia Bösmüller
Multimorbidity, Polypharmacy
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medications can reduce unplanned…
- Trial name
- OPTIMATE (NCT05387096)
- Testing
- Definitive multi-faceted intervention consisting of several components
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 642 people
- Sponsor
- University College Cork
Nuclear Medicine, Oncology
Application of 18F-FDG PET/MRI for Initial Staging in Locally Advanced Nasopharyngeal Carcinoma
This single-center prospective observational study aims to evaluate the feasibility, cost-effectiveness, and clinical value of positron emission tomography/magnetic resonance imaging (PET/MRI) for initial staging in patients with…
- Trial name
- NCT06947759
- Testing
- PET/MRI
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taichung Veterans General Hospital
Cannabis Use Disorder, Anxiety
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression.
- Conditions
- Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT06920238
- Testing
- Therabot-CALM
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Trustees of Dartmouth College
Rheumatoid Arthritis
Prednisone Timed-Release Tablet (TRT) Study: Modified-Release (MR) Formulation of Prednisone Compared to Standard Immediate-Release (IR) Prednisone in Participants With Rheumatoid Arthritis
The objective of this study is to investigate if low doses of prednisone MR formulation, given at night and, with active drug release at 2 am, are more effective in controlling joint stiffness, and other disease symptoms of…
- Trial name
- NCT00146640
- Testing
- MR Prednisone, IR Prednisone
- Where
- 24 sites in Germany, Poland
- Volunteers
- 288 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Diabetic Kidney Disease, Potassium Imbalance
Impact of Long-term Serum Magnesium and Potassium Levels Optimization and Multifactorial Adherence Intervention on the Progression of Diabetic Kidney Disease.
Insufficient clinical evidence correlates the progression of diabetic kidney disease with electrolyte homeostasis in patients diagnosed with type 2 diabetes mellitus (T2DM), especially in the United Arab Emirates (UAE) population…
- Conditions
- Diabetic Kidney Disease, Potassium Imbalance, Magnesium Deficiency
- Trial name
- NCT04942119
- Testing
- Multifactorial intervention
- Where
- United Arab Emirates
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Ankylosing Spondylitis, Spondylitis, Ankylosing
The Effect of Mobile Application on Subcutaneous Anti-TNF Drug Administration:Ankylosing Spondylitis Patients
This study was carried out to develop an android mobile application for the subcutaneous (SC) anti-TNF drug administration of ankylosing spondylitis patients and to evaluate its effect on drug administration.
- Trial name
- NCT04301128
- Testing
- Experimental, control
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Eskisehir Osmangazi University
Stenosis, Occlusion
Sequent Please Drug Coated Balloons Versus Primary Stent Application in Long SFA Lesions
Patients with peripheral artery disease will be treated with either drug coated balloon catheter, drug coated stent or uncoated stent.
- Conditions
- Stenosis, Occlusion, Restenosis
- Trial name
- SPORTS (NCT03332264)
- Testing
- SeQuent Please OTW, Eluvia Vascular Stent System, Nitinol stent
- Where
- 10 sites in Austria, Germany
- Volunteers
- 224 people
- Sponsor
- InnoRa GmbH
Opioid-Related Disorders, Opioid-use Disorder
RETAIN: Retaining Opioid Users Entering Medication Assisted Treatment and Encouraging HCV/HIV Testing
The purpose of this research study is to: 1. assess how well individuals entering medication assisted treatment like the RETAIN e-health application as measured by their feedback on the intervention. 2.
- Conditions
- Opioid-Related Disorders, Opioid-use Disorder, Drug Addiction, Substance Use Disorders
- Trial name
- RETAIN (NCT03411265)
- Testing
- self-administered, e-health application
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Opioid Use Disorder
Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents
This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention.
- Trial name
- SARA RCT (NCT06732596)
- Testing
- Embodied conversational agent (ECA), Technical support, Additional ECA messages
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Medical Center
Cancer, Adherence to Medication Regime
Mobile Application to Assist Adherence to Oral Anticancer Agents and Symptom Management
The use of oral anticancer agents (OAAs) in cancer treatment has increased especially in the last two decades. The use of mobile health technologies in the management of OAA can be beneficial in terms of treatment adherence and…
- Conditions
- Cancer, Adherence to Medication Regime, Symptom Management
- Trial name
- NCT04626830
- Testing
- Mobile Application Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Baskent University
Epilepsy, Unspecified, Pharmacologically Resistant, Memory Impairment
Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the…
- Trial name
- MemO-Epi (NCT01919957)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Postoperative Nausea and Vomiting, Surgery
The Application of Transversus Abdominis Plane Block Plus Rectus Sheath Block in Clinical Anesthesia
Peritoneal dialysis (PD) catheter placement surgery for patients with end-stage renal disease (ESRD) can be performed under peripheral nerve block.
- Conditions
- Postoperative Nausea and Vomiting, Surgery, Anesthesia, Peritoneal Dialysis
- Trial name
- NCT02984865
- Testing
- Sulfentanyl, Nalbuphine, flubiprofen axetil
- Where
- China
- Volunteers
- 190 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Chronic Heart Failure, Self-care
Construction and Application of a Self-Care Behavior Intervention Scheme for Chronic Heart Failure Patients Based on Interaction Model of Client Health Behavior
The purpose of this study, which will last for 3 months, is to investigate the effect of the intervention based on the interaction model of health behavior on patients' disease perception, heart failure self-care level, quality…
- Conditions
- Chronic Heart Failure, Self-care, Health Education
- Trial name
- NCT06759987
- Testing
- self-care behavior intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhi-fen Feng
Mandible Fracture
Effect of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate on Bone Quality in Mandibular Fracture Healing.
The goal of study is to evaluate the effectiveness of adipose tissue derived-MSCs concentrate application in mandibular fractures.
- Trial name
- NCT07671183
- Testing
- Adipose tissue derived mesenchymal stem cells concentrate application in addition to the open reduction and internal fixation., Open reduction and internal fixation
- Volunteers
- 20 people
- Sponsor
- Cairo University
Cardiac and Respiratory Arrest
SST in Emergency Education
This study looks back at how the investigatorsll two different teaching methods work for training medical and nursing students in CPR (cardiopulmonary resuscitation), a life-saving emergency procedure used when someone's heart…
- Trial name
- SST (NCT07803861)
- Testing
- case-based scenario simulation teaching
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anti-Infective Agents, Mobile Applications
A Digital Antimicrobial Stewardship Smartphone Application to Combat AMR: the AB-assistant
Optimal prescribing of antimicrobials is becoming increasingly challenging because of the growing complexity of guidelines and constantly changing distribution of infectious pathogens.
- Conditions
- Anti-Infective Agents, Mobile Applications, Quality Improvement, Antimicrobial Stewardship
- Trial name
- AB-assistant (NCT03793946)
- Testing
- AB-assistant
- Where
- 4 sites in Canada, Netherlands and 2 more
- Volunteers
- 1,080 people
- Sponsor
- Annelies Verbon