Clinical trials: Drug Application
Neurodegenerative Diseases
Study on the Application of ¹⁸F-FCOB04, a MAO-B Targeted PET Imaging Agent, in Neurodegenerative Diseases
In this clinical trial, we intend to perform 18F-FCOB04 PET imaging in patients with neurodegenerative diseases to observe the brain uptake of this tracer.We will investigate the distinct imaging patterns of brain MAO-B…
- Trial name
- NCT07470710
- Testing
- 18F-FCOB04
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Ductal Adenocarcinoma
Exploring the Application of 3D Bioprinting for Personalized Treatment in Pancreatic Ductal Adenocarcinoma
The goal of this observational study is to test the application value of 3D bioprinting technology in personalized treatment of pancreatic cancer.
- Trial name
- NCT05955092
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Overall Skin Appearance, Dry Skin; Eczema
RCT to Evaluate the Cosmetic Efficacy of Demo-cosmetic Active Ingredient CLS02021
This study will explore the potential of probiotic based, novel cosmetic active ingredient to rebuild the collagen based skin barrier with the overall aim to rejuvenate ageing or damaged skin, improve skin integrity, appearance…
- Trial name
- NCT05048121
- Testing
- Cosmetic Active Ingredient CLS02021
- Where
- 2 sites in Bosnia and Herzegovina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anbiome Labs LLC
Cystic Fibrosis, Cystic Fibrosis in Children
Feasibility of a Mobile Medication Plan Application in CF Patient Care
This is a pilot, multicenter, prospective, randomized controlled study to evaluate the feasibility of an innovative medication adherence intervention utilizing a web-based, mobile medication management application [MedActionPlan®…
- Trial name
- MAP (NCT03637504)
- Testing
- MedActionPlan®
- Where
- 5 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
an Intelligent Teaching Agent for the "Epidemiology" Course of the MBBS Program, Students' Critical Thinking, Practical Ability and Learning Outcomes
Research and Application of an AI Agent-Based MBBS Course Assistant
Prior to the quasi-experiment, this study performed semi-structured interviews among Bachelor of Medicine and Bachelor of Surgery(MBBS) undergraduate students from the Belt and Road International Medical College, Zhejiang…
- Trial name
- NCT07752160
- Testing
- Socratic Agent for Guided Epidemiology, General LLM
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Non-small Cell Lung Cancer
A Study of PC Sequential Pemetrexed Single Drug Maintenance Treatment for NSCLC and Related Predictive Biomarkers
PFS
- Trial name
- NCT01860508
- Testing
- pemetrexed /carboplatin
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Fudan University
Epidemiologic Factors
Patient Characteristics in Daily Radiological Practice of Gadovist® Application (PATRON)
To evaluate patient characteristics in the current daily radiological practice of Gadovist application. Special focus will be laid on the individual risk factors of patients, the indications for and the dose of Gadovist…
- Trial name
- NCT00874640
- Testing
- Gadobutrol (Gadovist, BAY86-4875)
- Where
- Germany
- Volunteers
- 3,711 people
- Sponsor
- Bayer
Metabolic Syndrome (MetS)
Use of a Mobile Application for Tracking Physical Activity in the Management of Metabolic Syndrome in Primary Care
This study will explore whether integrating a mobile app to track physical activity-recommended by family doctors during routine primary care visits-can help individuals with metabolic syndrome become more active.
- Trial name
- IMAFIL (NCT07236450)
- Testing
- Mobile Application and Wearable Device for Physical Activity Monitoring
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Andreia Lobo
ARTIFICIAL INTELLIGENCE (AI) APPLICATIONS IN REPRODUCTIVE MEDICINE
ARTIFICIAL INTELLIGENCE IN REPRODUCTIVE MEDICINE
Many studies have been published investigating the use of AI as an unbiased, automated approach to embryo assessment. This review will summarize the recent AI advancements in the IVF field.
- Trial name
- AI in ART (NCT05699850)
- Testing
- ARTIFICIAL INTELLIGENCE (AI)
- Where
- 2 sites in Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al Baraka Fertility Hospital
Multiple Sclerosis
VIGIP-SEP2: Training of Patients by Nurses on ADR Reporting by RRMS Patient Via an App
The patient's reporting of adverse drug reactions (ADRs) is recognized as being of interest for post-marketing safety monitoring, but is still underdeveloped in France, with an average lower than the European average.
- Trial name
- VIGIP-SEP2 (NCT04116424)
- Testing
- nurse training of the patient, neurologist accompaniement
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Caen
Palmar-Plantar Erythrodysesthesia, Palmar-Plantar Erythrodysesthesia Due to Cytotoxic Therapy
Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar Erythrodysesthesia
This is a single-centre, phase II, three-arm, randomised controlled trial to evaluate the efficacy and safety of a cosmetic moisturising cream containing palm-oil-derived vitamin E concentrate or a similar moisturising cream…
- Trial name
- ECaPPE (NCT05939726)
- Testing
- Moisturising cream with vitamin E concentrate, Moisturising cream without vitamin E concentrate, Urea cream
- Where
- Malaysia
- Volunteers
- 145 people
- Sponsor
- Sarawak General Hospital
Drug-Resistant Epilepsy, ARX-Related Epilepsy
Occupational Therapy Approach in ARX-Related Epilepsy
This study evaluated the effects of medical ketogenic diet therapy combined with occupational therapy in children with ARX-related epilepsy. Twenty children were included.
- Trial name
- NCT07745608
- Testing
- Occupational Therapy, Medikal Ketogenic Diet Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Uskudar University
HIV
HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP)
Black men who have sex with men (MSM) Pre-Exposure Prophylaxis (PrEP) Study with Client Centered Care Coordination (C4) Component.
- Trial name
- NCT01808352
- Testing
- Observational
- Where
- 3 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
Sensitivity, Tooth
Dentinal Hypersensitivity Reduction Efficacy Study
Assess the clinical efficacy of CSPR Toothpaste containing 8% arginine to provide dentinal hypersensitivity relief
- Trial name
- NCT06960148
- Testing
- CSPR Toothpaste, Colgate Dental Cream Toothpaste
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
HIV
Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women
This study will inform international medical guidelines as to whether the Levonorgestrel intrauterine device (LNG IUD), a highly effective long-acting reversible contraceptive method, is safe and acceptable as compared to the…
- Trial name
- NCT01721798
- Testing
- Mirena levonorgestrel IUD, Copper T-380a IUD
- Where
- South Africa
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- FHI 360
Skin Aging on Face, Skin Care Dermocosmetics
Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging
Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+).
- Conditions
- Skin Aging on Face, Skin Care Dermocosmetics, Skin Care, Fine Lines and Wrinkles
- Trial name
- NR-RADIANCE (NCT07774000)
- Testing
- Topical niacinamide riboside
- Where
- South Africa
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- ChromaDex, Inc.
Heart Failure
The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients
The SmartHF study is a 12-week prospective randomized controlled multicenter clinical trial. This study will investigate the efficacy of an adaptive web application to facilitate guideline-directed medical therapy (GDMT)…
- Trial name
- SmartHF (NCT05858320)
- Testing
- SmartHF application
- Where
- 5 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of Michigan
Bacterial Reduction on Skin Flora Post-product Application
In-vivo Efficacy Study of Patient Pre-operative Preps
The purpose of this study is to determine the antimicrobial efficacy of the 3M CHG/IPA Prep on skin flora of the abdominal and inguinal regions of human subjects.
- Trial name
- NCT01968707
- Testing
- ChloraPrep Hi-Lite Orange, Normal saline, 3M CHG/IPA Prep Tint 10.5-mL
- Where
- United States
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Ankylosing Spondylitis
Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS
The drug regimes in treating ankylosing spondylitis(AS) have limitations. The tumor necrosis factor inhibitors(TNFi) was effective but expensive. Disease modifying anti-rheumatic drugs (DMARDs) were cheap but insufficient.
- Trial name
- NCT03411798
- Testing
- Yisaipu®
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Adverse Effects
The Pharmacokinetics of 4% Lidocaine Gel When Applied Topically to the Breasts
The purpose of this study is to test the hypothesis that one-time application of 4% lidocaine gel (TOPICAINE) on the skin of the breasts and chest wall as recommended for pre-medication to reduce discomfort during screening…
- Trial name
- NCT00925353
- Testing
- 4% lidocaine gel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mountain States Tumor and Medical Research Institute