Clinical trials: Drug Application
Sinus Arrhythmia, Atrial Fibrillation
Electrophysiologically Guided PAcing Site Selection Study
This study is a long-term, prospective, and controlled evaluation of the incidence of persistent atrial fibrillation (AF) in patients with severe intra-right atrial conduction delay paced with preventive algorithms at the…
- Trial name
- EPASS (NCT00239226)
- Testing
- IAS pacing - study group, IAS pacing control group, Pacing RAA study group
- Where
- 8 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Medtronic BRC
Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery
Hypothesis: Topical application of Tranexamic acid into the surgical wound during spine surgery will decrease the overall blood loss post-operatively. This reduction in blood loss will reduce the need for transfusion.
- Trial name
- NCT02063035
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Prescription Drug Abuse (Not Dependent)
Mobile Application for Prescription Drug-Abuse Education (MAPDE)
The aims of this pilot study are: (1) to assess the feasibility and acceptability of a mobile application to educate military members about the risks of prescription drug misuse; (2) to determine if there is evidence that the…
- Trial name
- MAPDE (NCT03165175)
- Testing
- prescription drug-abuse education smartphone application
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
Headache, Cognitive Disturbance
Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease
Purpose: There are two goals we have for this prospective single arm study; to see an increase in the amount of gadolinium in 24 hour urine collection following each infusion treatment with Calcium and Zinc DTPA, and to see a…
- Conditions
- Headache, Cognitive Disturbance, Skin Hyperpigmentation, Arthralgia
- Trial name
- NCT02947022
- Testing
- Calcium DTPA, Zinc DTPA
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Health Education
Effects of Patient-centered Stroke Educating System: a Randomized Controlled Trial
The aim of this study is to establish PAtient-Centered Computerized Educating System for Stroke (PACCESS) for patients with different demands and lack of knowledge.Those in the intervention group will receive the PACCESS and the…
- Trial name
- NCT02591511
- Testing
- smart phone and pad, stroke-related health education manual
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Pediatric Emergency Medicine, Communication
PIMPmyHospital: a Mobile App to Improve Emergency Care Efficiency and Communication
This pilot study is a prospective, single-center, randomized, controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary post-graduate year 1 to 5 pediatric residents and registered…
- Trial name
- NCT05203146
- Testing
- PIMPmyHospital (mobile health tool), Conventional method
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Hypogonadism
A Study Using Recombinant Human Luteinizing Hormone (r-hLH, Luveris®) in the Treatment of Chinese Women With Hypogonadotropic Hypogonadism
This was a prospective, open, non-comparative study to evaluate the safety and efficacy of recombinant human luteinizing hormone (rhLH, Luveris) administered subcutaneously (s.c.) in follicular development during ovulation…
- Trial name
- NCT01084265
- Testing
- Recombinant human luteinizing hormone (r-hLH), Recombinant human follicle-stimulating hormone (r-hFSH), Human chorionic gonadotropin (hCG)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Bacterial Reduction Post-product Application
In Vivo Efficacy Study of Patient Preoperative Preps
The objective of this study is to demonstrate the antimicrobial efficacy of the 3M CHG/IPA Prep on skin flora of the abdominal and inguinal regions of human subjects.
- Trial name
- NCT02203591
- Testing
- 3M CHG/IPA Prep C, 3M CHG/IPA Prep CH, ChloraPrep
- Where
- United States
- Volunteers
- 738 people, healthy volunteers welcome
- Sponsor
- 3M
Medication Administered in Error, Antipsychotics and Neuroleptics Toxicity
Novel Application of Simulation for Providers to Overcome Decisional Gaps in High-risk Prescribing
This pilot project aims to reduce the prescribing of high-risk medications, such as antipsychotics and benzodiazepines, to hospitalized older adults. To accomplish this, this project consists of two phases.
- Trial name
- NCT04668248
- Testing
- Simulation, Online educational training
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Brigham and Women's Hospital
Bacterial Recovery of Skin Flora Post-Product Application
In Vivo Patient Preoperative Skin Prep Persistence
The objective of the study is to demonstrate persistence of the CHG/IPA Prep on skin flora of the abdominal and inguinal regions of human subjects.
- Trial name
- NCT02447497
- Testing
- 3M CHG/IPA Surgical Skin Preparation - Abdominal Region, Normal Saline - Abdominal Region, 3M CHG/IPA Surgical Skin Preparation - Inguinal Region
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Contraception
PK of Depo SubQ Injected in the Upper Arm
A single-arm trial to demonstrate that Depo-SubQ Provera injected in the upper arm is adequate for effective contraception
- Trial name
- NCT01143207
- Testing
- Medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- FHI 360
Healthy Men, Male Contraception
Study of Serum Testosterone and Nestorone in Females After Secondary Exposure to Nestorone ® (NES) + Testosterone (T) Combined Gel Applied to Shoulders and Upper Arms in Males
This is a two-center, open-label study conducted in healthy male and female volunteers at two academic research centers. The study will consist of three single applications of the Nestorone (NES) + testosterone (T) combined gel…
- Conditions
- Healthy Men, Male Contraception, Healthy Women, Product Transference
- Trial name
- CCN005B (NCT02994602)
- Testing
- Nestorone + Testosterone Combination Gel
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Bacterial Recovery of Skin Flora Post-product Application
In Vivo Preoperative Skin Preparation Persistence Evaluation
Evaluate persistent antimicrobial effectiveness of chlorhexidine gluconate containing products on abdominal and inguinal sites following a saline and wipe challenge.
- Trial name
- NCT03155178
- Testing
- 3M CHG/IPA Prep, ChloraPrep
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Rheumatoid Arthritis
Prednisone Timed-Release Tablet (TRT) Study: Modified-Release (MR) Formulation of Prednisone Compared to Standard Immediate-Release (IR) Prednisone in Participants With Rheumatoid Arthritis
The objective of this study is to investigate if low doses of prednisone MR formulation, given at night and, with active drug release at 2 am, are more effective in controlling joint stiffness, and other disease symptoms of…
- Trial name
- NCT00146640
- Testing
- MR Prednisone, IR Prednisone
- Where
- 24 sites in Germany, Poland
- Volunteers
- 288 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Scalp Psoriasis
Safety Study in Patients With Scalp Psoriasis Suppression Following Maximal Use Treatment With Topical Product
An Open-Label, Safety Study to Assess the Potential for Adrenal Suppression Following Maximal Use DSXS topical product (Taro Pharmaceuticals U.S.A., Inc.) in Patients with Moderate to SevereScalp Psoriasis
- Trial name
- NCT02933502
- Testing
- DSXS topical product
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries, Inc.
White Spot Lesion
Efficacy Evaluation of Two Different Fluoride Applications
The goal of this clinical trial is to evaluate the remineralizing or preservative effect of two different fluoride-containing products.
- Trial name
- NCT06131294
- Testing
- Fluoride Application (Experimental Fluoride Application), Fluor Protector S
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Ivoclar Vivadent AG
Sunscreening Agents
Clinical Study to Evaluate the Efficacy of an Over-the-counter (OTC) Sunscreen Lip Balm Product
The purpose of this study is to evaluate the 8-hour moisturization efficacy of OTC sunscreen lip balm after a single treatment application.
- Trial name
- NCT05109117
- Testing
- CAP Unscented
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- HALEON
HIV
Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women
This study will inform international medical guidelines as to whether the Levonorgestrel intrauterine device (LNG IUD), a highly effective long-acting reversible contraceptive method, is safe and acceptable as compared to the…
- Trial name
- NCT01721798
- Testing
- Mirena levonorgestrel IUD, Copper T-380a IUD
- Where
- South Africa
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- FHI 360
Bacterial Reduction on Skin Flora Post-product Application
In-vivo Efficacy Study of Patient Pre-operative Preps
The purpose of this study is to determine the antimicrobial efficacy of the 3M CHG/IPA Prep on skin flora of the abdominal and inguinal regions of human subjects.
- Trial name
- NCT01968707
- Testing
- ChloraPrep Hi-Lite Orange, Normal saline, 3M CHG/IPA Prep Tint 10.5-mL
- Where
- United States
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Adverse Effects
The Pharmacokinetics of 4% Lidocaine Gel When Applied Topically to the Breasts
The purpose of this study is to test the hypothesis that one-time application of 4% lidocaine gel (TOPICAINE) on the skin of the breasts and chest wall as recommended for pre-medication to reduce discomfort during screening…
- Trial name
- NCT00925353
- Testing
- 4% lidocaine gel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mountain States Tumor and Medical Research Institute