Clinical trials: Drug Discontinuation
Coronary Artery Disease
3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation
To evaluate safety of reduction of dual antiplatelet therapy period to three months after implantation of Ultimaster sirolimus-eluting stent (U-SES).
- Trial name
- MODEL U-SES (NCT02837003)
- Testing
- Aspirin, Thienopyridine
- Where
- Japan
- Volunteers
- 1,500 people
- Sponsor
- Teikyo University
Homonymous Hemianopsia
Ongoing Effect of Expansion Prisms Following the Discontinuation of Use on Visual Field Enlargement and Retrograde Ganglion Cell Degeneration in Homonymous Hemianopia Patients
The goal of this observational study is to learn about the long-term effects of Pelli prism in Hemianopia patients who take Prisms for awareness of the area they cannot see.
- Trial name
- NCT06674369
- Testing
- Peli prism for hemianopia
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Okan University
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Opioid-Related Disorders, Opiate Addiction
Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic Pain
The purpose of this study is to evaluate the effect on pain intensity (PI) of structured discontinuation of long-term opioid analgesic therapy compared to continuation of opioid therapy in Suboptimal and Optimal Responders to…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02741076
- Testing
- Structured discontinuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER), Continuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER)
- Where
- 61 sites in United States
- Volunteers
- 44 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Opioid Withdrawal (Disorder), Opioid Use Disorder
A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects
The goal of this clinical study is to evaluate the pharmacokinetic (PK), safety, and tolerability of LUCEMYRA in adolescents age ≥12 to <18 years old abruptly discontinuing opioid use.
- Trial name
- NCT06711640
- Testing
- LUCEMYRA (lofexidine) tablets
- Where
- United States
- Sponsor
- USWM, LLC (dba US WorldMeds)
Restenosis
The ITALIC Study: Is There A LIfe for Drug-eluting Stents (DES) After Discontinuation of Clopidogrel
Background Drug-eluting stents (DES) have been extremely successful in reducing restenosis and the need for repeat revascularization procedures in patients who undergo PCI.
- Trial name
- ITALIC (NCT00780156)
- Where
- France
- Volunteers
- 1,235 people
- Sponsor
- French Cardiology Society
Rheumatoid Arthritis (RA)
Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors
The goal is to investigate whether a strategy of attempting to discontinue of MTX or LEF (and restart when necessary) in RA patients treated with an optimal dose (allowed dose or lower, tapered to the maximum, or according to…
- Trial name
- DISCO (NCT07802678)
- Testing
- Strategy to attempt discontinuation of MTX or LEF (and restart when necessary), Continuation of MTX or LEF
- Where
- 4 sites in Netherlands
- Volunteers
- 202 people
- Sponsor
- Sint Maartenskliniek
Acute Myeloid Leukemia
Discontinuation of Hypomethylating Agent and Venetoclax in Patients With AML MRD
The purpose of this research study is to see if people whose Acute myeloid leukemia (AML) is being successfully treated with azacitidine or decitabine in combination with venetoclax can discontinue this chemotherapy for some…
- Trial name
- NCT06511882
- Testing
- Azacitidine, Decitabine, Venetoclax
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Sleep Disorders
Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription
Brief Summary Context. Sleep disorders complaints are common in elderly and hypnosedative drugs are widely prescribed in community-dwelling elderly.
- Trial name
- HYPAGE (NCT02296957)
- Testing
- Hypnosedative discontinuation
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
NVP Plasma Level, NVP Related Mutation
Nevirapine Clearance After Short-term Highly Active Antiretroviral Therapy (HAART) for Prevention of Mother to Child Transmission of HIV (PMTCT)
Three-drug combination of antiretroviral regimens has been used increasingly in HIV-infected pregnant women worldwide, both for the prevention of mother to child transmission of HIV (PMTCT) and for women's own health.
- Conditions
- NVP Plasma Level, NVP Related Mutation, 3TC Related Mutation
- Trial name
- NCT00872872
- Testing
- AZT/3TC 2 weeks after delivery
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Thai Red Cross AIDS Research Centre
Cardiovascular Prevention
Assessment of Low-dose ASA Discontinuation Risk Associated With Concomitant PPI Use During the First Year of ASA Therapy
This study is conducted in a cohort of low dose aspirin (ASA) users previously ascertained .The aims of the post hoc analyses are: To estimate the one year risk of discontinuation of use of low-dose ASA associated to PPI…
- Trial name
- NCT01888575
- Testing
- Risk of low dose aspirin discontinuation
- Where
- Spain
- Volunteers
- 35,604 people
- Sponsor
- AstraZeneca
Prostate Cancer
A Study Using Available Data to Learn to What Extent Patients With Prostate Cancer Who Received Second Generation Androgen Receptor Inhibitors Took Their Medication as Prescribed or Stopped Taking Their Medication Completely
This is an observational study in which patient data from the past on men with prostate cancer are studied. Cancer is a condition in which the body cannot control the growth of cells and tumors may form.
- Trial name
- NCT05202301
- Testing
- Darolutamide (Nubeqa, BAY1841788), Enzalutamide, Apalutamide
- Where
- United States
- Volunteers
- 13,779 people
- Sponsor
- Bayer
HIV Infections
Effects of Therapeutic HIV Vaccination on Control of HIV After Discontinuation of Anti-HIV Drugs
The purpose of this study is to determine whether therapeutic HIV vaccines can help the immune system control HIV viral load after anti-HIV drugs are discontinued.
- Trial name
- NCT00050063
- Testing
- Therapeutic vaccinations from A5058s
- Where
- 14 sites in United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Apnea of Prematurity, Caffeine
Target Weaning Oxygen to Determine Cafffeine Duration for AOP
Caffeine, a typical representative of methylxanthine, is world-widely used to manage apnea of prematurity (AOP) in neonatology. However, an appropriate medication regimen of caffeine has not been well defined until now.
- Conditions
- Apnea of Prematurity, Caffeine, Weaning Oxygen, Medicine Regimen
- Trial name
- DCAP (NCT04868565)
- Testing
- Caffeine Citrate 20 MG/1 ML Intravenous Solution [CAFCIT]
- Where
- 41 sites in China
- Volunteers
- 310 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Osteoarthritis
A Prospective Observational Study on Discontinuation of Medication of Shinbaro Capsule
This study investigates how gastrointestinal toxicity affects discontinuation of medication given to patients with osteoarthritis in routine clinical practice.
- Trial name
- NCT02064634
- Where
- South Korea
- Volunteers
- 6,700 people
- Sponsor
- Green Cross Corporation
Surgery, Platelet Dysfunction
Low-dose Acetylsalicylic Acid Before Non-cardiac Surgery
This study aims to assess independent factors associated with the clinical decision to discontinue ASA preoperatively in patients undergoing elective non-cardiac surgery.
- Trial name
- NCT03049566
- Testing
- preoperative questionnaires
- Where
- Germany
- Volunteers
- 805 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypnotic Withdrawal
The Impact of a Pharmacist Intervention on Post-discharge Hypnotic Drug Discontinuation in Geriatric Inpatients
This study investigated whether a multifaceted approach was associated with hypnotic drug discontinuation at one month after discharge
- Trial name
- NCT05521971
- Testing
- multifaceted pharmacist-led intervention, Usual care group
- Volunteers
- 173 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Disease
Managing Infliximab Reinduction After Temporary Discontinuation of Drug
The primary purpose of the project is to determine what is the best schedule for restarting infliximab in patients with inflammatory bowel disease (IBD) specifically ulcerative colitis and Crohn's disease, who have undergone…
- Trial name
- NCT02771457
- Testing
- Infliximab at weeks 0,2, and 6, Infliximab at weeks 0,4, and 8, Infliximab at weeks 0 and 8
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study
The Main Hypothesis of this extension trial is that among those who have successfully discontinued their DMT as part of the DISCOMS trial (i.e.
- Trial name
- NCT04754542
- Where
- 10 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Colorado, Denver
Antidepressants
Discontinuation of Antidepressant Medication in Primary Care.
To investigate the effectiveness of the combination of Supported Protocolized Discontinuation (SPD) and Mindfulness-Based Cognitive Therapy (MBCT) in comparison with SPD alone in successful discontinuation of long-term use of…
- Trial name
- NCT03361514
- Testing
- Supported Protocolized Discontinuation (SPD), Mindfulness Based Cognitive Therapy (MBCT)
- Where
- Netherlands
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center