Clinical trials: Drug Distribution
Healthy Volunteers
A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348
This study will assess absorption, distribution, metabolism, excretion and absolute bioavailability of AG-348 in healthy male participants.
- Trial name
- NCT03703505
- Testing
- AG-348, [13C6]AG-348
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
KOA
A Study of [89Zr]-Oxine-NCR100 Injection for the Cellular Distribution
This clinical study is to evaluate the biodistribution of [89Zr]-Oxine-NCR100 injection in subjects with knee osteoarthritis after local injection and the kinetic behavior characteristics of zirconium-labeled cells at the…
- Trial name
- Distribution (NCT07139431)
- Testing
- NCR100
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Cardiovascular Complication
RDW to Platlet Count Ratio in CKD Patients
The aim of the study is to determine Red blood cell distribution width to platelet count ratio as a predictor of cardiovascular complications in CKD patients
- Trial name
- NCT05754827
- Testing
- RDW to platlet count ratio
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy, Speech Disorders
Development of Normative Ultrasound Databases of Tongue Surface Configuration
Our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations.
- Trial name
- NCT00001218
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Obesity, Visceral, Cardiovascular Diseases
Impact of Liraglutide 3.0 on Body Fat Distribution
This study is a clinical study to investigate the efficacy of liraglutide compared to placebo in reducing visceral adiposity measured by MRI in overweight or obese subjects at high risk for cardiovascular disease after 40 weeks…
- Conditions
- Obesity, Visceral, Cardiovascular Diseases, Fat Disorder
- Trial name
- NCT03038620
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Healthy
Procalcitonin Test Reference Range Determination
Prospective, single-centre study in healthy volunteers to establish a reference range for the RAMP Procalcitonin (PCT) test. The primary objective of this study is to establish the reference range for measurement of PCT levels…
- Trial name
- PRO-H (NCT02591121)
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Response Biomedical Corp.
Pharmacies, Opioid Use
RESPOND TO PREVENT: Stepwise Pharmacy Naloxone Study
This multi-site study will test the efficacy of an intervention to train and equip pharmacists to provide naloxone, an overdose antidote, to patients using prescribed and illicit opioids, to improve opioid safety and prevent…
- Conditions
- Pharmacies, Opioid Use, Patient Safety
- Trial name
- NCT03545321
- Testing
- MOON+
- Where
- 5 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Brandeis University
Healthy Adult Male Volunteers
ADME Study of [14C]- Rongliflozin in Healthy Male Subjects
Study to Evaluate the Mass Balance and Biotransformation of Single Dose [14C]- Rongliflozin in healthy male subjects.
- Trial name
- NCT05109078
- Testing
- [14C]- Rongliflozin
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
HIV Infections
Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe
The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in…
- Trial name
- NCT00390949
- Testing
- Peer education among commercial sex workers and clients, Condom distribution and promotion, Syndromic treatment of sexually transmitted infections
- Where
- Zimbabwe
- Volunteers
- 9,454 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Muscle Fatigue
Tibialis Posterior Fatigue and Plantar Pressure
The purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol.
- Trial name
- NCT04415099
- Testing
- Muscle fatigue protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy
PK, Safety & Tolerability of CyCol® Versus Sandimmune® in Healthy Subjects
The aim of this Phase I, single centre, multi stage study is to evaluate the safety, tolerability, pharmacokinetics and relative colonic mucosal concentrations of cyclosporine capsules (CyCol®) compared to intravenous…
- Trial name
- CYC102 (NCT02130414)
- Testing
- Sandimmun® IV, CyCol® capsules
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sigmoid Pharma
Covid19
COVID-19 Self-Testing Through Rapid Network Distribution
COVID-19, the coronavirus disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has led to a global pandemic and has exacerbated existing health inequities among vulnerable populations.
- Trial name
- C-STRAND (NCT04797858)
- Testing
- COVID-19 self-test, COVID-19 test referral
- Where
- United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Male Subjects
ADME Study of [14C] Yiqibuvir in Healthy Male Subjects
This is a single-centre, open-label, mass balance and biotransformation study in healthy male subjects utilising a single oral dose of [14C] Yiqibuvir.
- Trial name
- NCT05998304
- Testing
- [14C] Yiqibuvir
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Polycystic Ovary Syndrome, Hypothalamic Amenorrhea
Body Fat as Determinant of Female Gonadal Dysfunction
Reproduction requires from women enough energy depots to warrant an adequate nutritional supply to the fetus. Hence, adipose tissue is able to communicate with female hypothalamic-pituitary-ovary axis.
- Trial name
- NCT03841981
- Testing
- Anthropometric and physical examination, Indirect calorimetry, accelerometer and seven-day dietary recall, Biochemical, hormonal and metabolic phenotyping
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Healthy Volunteer
A Pharmacodynamic Study to Evaluate Neutrophil Distribution Kinetics and Function Following Single-Dose RoActemra/Actemra (Tocilizumab) in Healthy Volunteers
This Phase IV, single-blind , randomized, two-arm study will explore the pharmacodynamics effects of RoActemra/Actemra (tocilizumab) on neutrophil redistribution, function and survival in healthy subjects.
- Trial name
- NCT01991990
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Cystic Fibrosis
Effect of the CFTR-modulating Triple Therapy Elexacaftor - Tezacaftor - Ivacaftor
The aim of this study is to investigate the frequency distribution, cytokine profile and function of peripheral, mononuclear leukocyte populations (monocytes, NK cells, T/B lymphocytes) and their correlation to clinical and…
- Trial name
- NCT05576324
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Balanced, Weight, Body
Balance and Weight Distributions at Kneeling
This study aims to examine balance parameters and weight distributions at different kneeling positions.
- Trial name
- NCT05678842
- Testing
- Descriptive
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Nasopharyngeal Carriage of Streptococcus Pneumoniae
Pneumococcal Carriage, Serotypes, and Antibiotic Resistance in Malaysian Children: A Multi-Centre Study
The goal of this observational study is to determine the prevalence, serotype distribution, and antimicrobial resistance patterns of nasopharyngeal carriage of Streptococcus pneumoniae in Malaysian children aged ≤5 years…
- Trial name
- MY-PNEUMO2 (NCT07545876)
- Where
- 4 sites in Malaysia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Physical Activity, Physical Activity Intensity
Effects of Polarized and Threshold Intensity Distribution Models on Race Time and Body Composition in Recreational Runners Aged 20-45 Years.
This study aims to compare the effects of two intensity distribution training (TID) models-polarized and threshold-on 5-km race time and body composition in recreational runners aged 20 to 45 years.
- Conditions
- Physical Activity, Physical Activity Intensity, Physical Activity in Adults, Running
- Trial name
- NCT07498608
- Testing
- Polarized intensity distribution model, Threshold intensity distribution model
- Where
- Colombia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Pedagogica Nacional, Colombia
Congenital Urogenital Anomaly
Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis
Non-conspicuous penis (congenital megaprepuce, occult penis) is a symptomatic malformation that includes phimosis and excessively baggy, urine-filled prepuce with alteration of the appearance of the penis.
- Trial name
- DISMUD (NCT03295175)
- Testing
- Hematoxylin-eosin and smooth muscle actin markers
- Where
- Colombia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio