Clinical trials: Drug Eluting Stents
Myocardial Infarction
Angiography Versus (vs) IVUS Optimisation
The purpose of the study id to demonstrate an advantage for intra-vascular ultrasound (IVUS) optimized drug-eluting stent (DES) implantation compared to angiography in complex lesions
- Trial name
- AVIO (NCT00936169)
- Testing
- IVUS optimised DES implantation, angiographically guided DES implantation
- Volunteers
- 284 people
- Sponsor
- Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS
Coronary Artery Disease
Rotational Atherectomy for Calcified lEsion By Smart Angioplasty Research Team (SMART-RACE)
Current guidelines recommend the use of rotational atherectomy (RA) for preparation of heavily calcified or severely fibrotic lesions that cannot be crossed by a balloon or adequately dilated before planned stenting (bailout…
- Trial name
- NCT02716363
- Testing
- Rotational Atherectomy by Rotablator
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
PCI, In-stent Restenosis
Intravascular Imaging-Guided Versus Angiography- Guided PCI in Patients With DES-ISR
This study aimed to compare the clinical and angiographic outcomes of patients with DES-ISR who underwent repeat PCI with intravascular imaging or angiographic guidance.
- Conditions
- PCI, In-stent Restenosis, Intravascular Imaging Device
- Trial name
- NCT07297641
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Angina, Chronic Coronary Occlusion
XIENCE V/PROMUS Everolimus-Eluting Stent System Post-marketing Surveillance Protocol for Japan
The objectives of this post-marketing surveillance, conducted in Japan, is to know the frequency, type and degree of device malfunction, to assure the safety of the medical device, and to collect information on evaluation of the…
- Conditions
- Angina, Chronic Coronary Occlusion, Stent Thrombosis, Vascular Disease
- Trial name
- NCT01086228
- Testing
- XIENCE V / PROMUS stent
- Where
- 47 sites in Japan
- Volunteers
- 2,010 people
- Sponsor
- Abbott Medical Devices
Non ST-Segment Elevation Myocardial Infarction
Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.
Inflammation plays a central role in the pathophysiology of atherosclerosis and in the progression of coronary artery. Colchicine, an anti-inflammatory agent traditionally used for gout and pericarditis, has emerged as a…
- Trial name
- NCT07143136
- Testing
- Colchicine
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Atheroscleroses, Cerebral, Intracranial Atherosclerosis
Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)
To study the clinical outcomes after implantation of balloon-expandable drug-eluting stents in patients with symptomatic intracranial atherosclerotic stenosis in prevention of composite event of any stroke and death within 30…
- Conditions
- Atheroscleroses, Cerebral, Intracranial Atherosclerosis, Ischemia Stroke
- Trial name
- NCT06614972
- Testing
- Balloon-expandable drug-eluting stent
- Volunteers
- 520 people
- Sponsor
- RenJi Hospital
Vessel Restenosis
Dexamethasone-Eluting Stent in Acute Coronary Syndrome to Prevent Restenosis
The major obstacle of the long- termed success of percutaneous coronary intervention (PCI) is the restenosis. Restenosis results from complex pathophysiological response of the vascular tissue to the balloon injury.
- Trial name
- NCT00190099
- Testing
- Dexamethasone-Eluting Stent
- Volunteers
- 40 people
- Sponsor
- Far Eastern Memorial Hospital
Percutaneous Coronary Intervention
Comparative Registry of the PROmus™, ENdeavor™ and CYpher™ Drug Eluting Stents
The purpose of this study is to collect real-life data of the Promus™ stent, the Cypher™ stent and the Endeavor™ stent in routine clinical practice, and compare outcomes.
- Trial name
- ProEnCy (NCT00930878)
- Testing
- Cardiac Stenting
- Where
- Germany
- Volunteers
- 1,934 people
- Sponsor
- Boston Scientific Corporation
Peripheral Vascular Diseases, Chronic Total Occlusion of Artery of the Extremities
Excellence in Peripheral Arterial Disease Treatment of Superficial Femoral Artery Disease With Drug-eluting Stents
The superficial femoral artery (SFA) is frequently involved in atherosclerosis and is the most common target of lower extremity endovascular procedures performed in patients with claudication.
- Trial name
- XLPAD DES SFA (NCT03671655)
- Testing
- Drug-eluting stent, Bare metal stent
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- North Texas Veterans Healthcare System
Coronary Artery Disease
Drug Eluting Stent Registry of Thrombosis
Multicenter, case-control study, to collect data regarding incidences of late and very late drug-eluting stent thrombosis with the aim of identifying trends and possible correlates of stent thrombosis.
- Trial name
- DESERT (NCT00812552)
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 984 people
- Sponsor
- Medstar Health Research Institute
Acute Myocardial Infarction
Drug-coated Balloon Versus Drug-eluting Stent in the Treatment of Coronary Artery Lesions in STEMI Patients in De Novo Coronary Lesions
The study aims to find a DCB treatment for STEMI patients can achieve early and mid-term functional outcomes that are not inferior to DES, and realize the strategy of intervention without implantation.
- Trial name
- NCT04072081
- Testing
- Drug-coated balloon, Drug-eluting stent
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
Evaluation of Effectiveness and Safety of Xience Skypoint Stents in Routine Clinical Practice
The objective of this study is to evaluate the effectiveness and safety of XIENCE Skypoint stents in comparison to other drug-eluting stents (DES) in real-world practice.
- Trial name
- IRIS Skypoint (NCT05981911)
- Testing
- XIENCE Skypoint™ stent
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seung-Jung Park
ST Elevation Myocardial Infarction
STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT
Primary percutaneous coronary intervention (PCI) is the preferred revascularization strategy for patients with acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- STARS DAPT (NCT05785897)
- Testing
- Successful primary PCI, defined as primary PCI of the culprit lesion with ≥1 Abluminus NP polymer-free sirolimus-based nanocarrier eluting stent (Concept Medical Inc., India) implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- IGLESIAS Juan Fernando
Coronary Artery Disease
(EASY)-IMProving Adherence to Clopidogrel Trial (IMPACT))
The purpose of this study is to test the impact of a multidisciplinary approach to improve the adhesion and persistence to Clopidogrel therapy.
- Trial name
- EASY-IMPACT (NCT01134679)
- Testing
- Multi-disciplinary disease management approach
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Myocardial Ischemia(Implanted Drug-eluting Stents Because of Ischemic Heart Disease(Stable Angina, Acute Coronary Syndrome))
Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study): Retrospective and Prospective Follow-up Study
The investigator aimed to evaluate the long-term (up to 10 years) follow-up of the patients who enrolled the IVUS-XPL study (Impact of IntraVascular UltraSound Guidance on the Outcomes of Xience Prime Stents in Long Lesions)…
- Trial name
- NCT03866486
- Where
- South Korea
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Safety and Efficacy of POT PTCA Balloon Dilatation Catheter for the Optimal Dilation After DES Implantation
The objective of this randomized control trial is to gain clinical insight on the use of POT PTCA balloon dilatation catheter for the optimal dilation after drug-eluting stent implantation.
- Trial name
- POT-DES (NCT05368129)
- Testing
- Balloon dilation
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease, Coronary Stent Occlusion
DXR Stent for Vascular Healing and Thrombus Formation: OCT Study
The purpose of this study is to evaluate the efficacy of a novel dual drug-eluting stent (DXR stent), which slowly releases both cilostazol and paclitaxel, for strut coverage, malapposition, and thrombus formation, assessed by an…
- Trial name
- NCT02932995
- Where
- 6 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Chung-Ang University
Acute Coronary Syndrome
Activity of Platelets After Inhibition and Cardiovascular Events Optical Coherence Tomography Study
It is an exploratory study evaluating a biological effect (stent strut coverage) using a novel technology such as OCT without any clinical implication.
- Trial name
- APICE-OCT (NCT01239654)
- Testing
- stent implantation
- Where
- 4 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Lesions
TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography
First prospective randomized controlled study to evaluate in an 'all-comers' population with coronary artery disease whether treatment with a novel everolimus eluting stent (EES) with a biodegradable polymer is superior to a…
- Trial name
- TRANSFORM (NCT01972022)
- Testing
- EES SYNERGY™, ZES, RESOLUTE Integrity™
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Coronary Artery Disease
Drug-Eluting Stenting Followed by Cilostazol tREAtment Reduces SErious Adverse Cardiac Events (DECREASE-PCI)
The DECREASE-PCI trial is a prospective, randomized, placebo controlled, double-blind, phase 4 study to evaluate efficacy and safety of triple anti-platelet therapy compared with dual antiplatelet therapy in patients treated with…
- Trial name
- NCT01346865
- Testing
- Cilostazol
- Where
- 12 sites in South Korea
- Volunteers
- 402 people
- Sponsor
- Seung-Jung Park