Clinical trials: Drug Eluting Stents
Coronary Artery Disease
Promus - Registry Experience at the Washington Hospital Center, Drug-eluting Stent (DES)
Single-center registry of patients treated with at least one Promus, everolimus-eluting, Stent, with the primary objective to assess clinical success and safety at 30 days, 6 months and 1 year post-implantation.
- Trial name
- P-REWARDS (NCT01003795)
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Coronary Artery Disease
BES, EES, and ZES-R in Real World Practice
The primary objective of this study is to compare the rate of device-oriented composite consisted of cardiac death, myocardial infarction not clearly attributable to a nontarget vessel, and clinically indicated target lesion…
- Trial name
- CHOICE (NCT01397175)
- Testing
- Biolimus-eluting stent, Everolimus-eluting stent, Zotarolimus-eluting stent
- Where
- 5 sites in South Korea
- Volunteers
- 1,960 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Efficacy of Xience/Promus Versus Cypher in rEducing Late Loss After stENTing
Objectives 1. To evaluate the safety and long-term effectiveness of coronary stenting with the Everolimus-eluting coronary stent system(EECSS) (XIENCETM V, Abbott Vascular, Santa Clara, CA, PromusTM, Boston Scientific, Natick…
- Trial name
- EXCELLENT (NCT00698607)
- Testing
- Everolimus-eluting stent (Xience or Promus), Sirolimus-eluting stent (Cypher), 6-month clopidogrel therapy
- Where
- South Korea
- Volunteers
- 1,466 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-IV: (LONG-DES-IV)
This randomized study is a multi-center, randomized, study to compare the efficacy of sirolimus (Cypher) versus zotarolimus-eluting stent (Endeavor Resolute) implantation for long coronary lesions.
- Trial name
- LONG-DES-IV (NCT01186094)
- Testing
- Cypher, Endeavor Resolute
- Where
- 12 sites in South Korea
- Volunteers
- 502 people
- Sponsor
- Seung-Jung Park
Coronary Heart Disease, Angioplasty, Balloon
Drug-coated Balloons and Drug-eluting Stents in Diabetic Patients
Drug-eluting stents (DES) have long been recommended as the default device for patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT05937230
- Testing
- Drug-coated balloon, Drug-eluting stents
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xijing Hospital
True Coronary Bifurcation Lesions
COmplex BifuRcation Lesions: a Comparison Between the AXXESS Device and Culotte Stenting: an Optical Coherence Tomography (OCT) Study
Treatment of bifurcation lesions with drug-eluting stents (DES) (especially when a double stent technique is used) is associated with a higher risk for stent thrombosis.
- Trial name
- COBRA (NCT01486095)
- Testing
- AXXESS + Biomatrix Biolimus Eluting stent, Culotte technique with Xience V or Xience Prime stents
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease
Drug-Coated Balloon in Patients With High Bleeding Risk
DCB-HBR trial is prospective, multi-center, open-label, randomized controlled, noninferiority trial. The aim of the study is to compare clinical outcomes of drug-coated balloon (DCB) with drug-eluting stent (DES) for treatment of…
- Trial name
- DCB-HBR (NCT05221931)
- Testing
- Percutaneous coronary intervention
- Where
- 17 sites in South Korea
- Volunteers
- 1,359 people
- Sponsor
- Samsung Medical Center
Unstable Anginas, Non ST Segment Elevation Myocardial Infarction
OCT Evaluation of Early Vascular Repair in Patients With Non ST Elevation Acute Coronary Syndrome (NSTE-ACS)
This is a prospective study of a new generation of drug-eluting stent in the treatment of non ST elevation acute coronary syndrome (NSTE-ACS).
- Trial name
- EXPECT (NCT04375319)
- Testing
- OCT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xuzhou Third People's Hospital
Coronary Artery Disease
Prospective Evaluation of Drug-Eluting Stents in Routine Clinical Practice (ASAN PCI Registry)
The objective of this study is to evaluate effectiveness and safety of drug-eluting stent implantation in the "real world" daily practice.
- Trial name
- NCT01788592
- Where
- South Korea
- Volunteers
- 50,000 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Drug Coated Balloon vs. Drug-eluting Stent in Patients With Coronary Artery Disease
Studies exploring the feasibility of drug-eluting balloon (DCB) in de-novo coronary lesions are limited. There are scarce data comparing DCB with drug-eluting stent (DES) in patients with high bleeding risk (HBR), a situation in…
- Trial name
- DCB_DES (NCT07442500)
- Testing
- Drug coated balloon, Drug-eluting stent
- Where
- South Korea
- Volunteers
- 470,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Percutaneous Transluminal Coronary Angioplasty
Evaluation of the First, Second, and New Drug-Eluting Stents in Routine Clinical Practice
The objective of this study is to evaluate effectiveness and safety of the new drug-eluting stent (DES), as compared with the first-,second-,third-, and fourth-generation DES, in the "real world" daily practice.
- Trial name
- IRIS-DES (NCT01186133)
- Where
- South Korea
- Volunteers
- 50,000 people
- Sponsor
- Seung-Jung Park
Myocardial Infarction
A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study
This study is a prospective, randomized controlled, single blind, two-arm, multi center clinical evaluation. A total of 1500 patients will be enrolled in the study.
- Trial name
- NCT00828087
- Testing
- Everolimus Eluting Coronary Stent System, cobalt chromium balloon expandable stent ( non drug eluting stent Arm)
- Where
- 11 sites in Italy, Netherlands and 1 more
- Volunteers
- 1,504 people
- Sponsor
- Spanish Society of Cardiology
Coronary Artery Disease, Coronary Stenosis
Z-SEA-SIDE: Sirolimus Versus Everolimus Versus Zotarolimus-eluting Stent Assessment in Bifurcated Lesions and Clinical SIgnificance of Residual siDE-branch Stenosis
BACKGROUND: Bifurcated lesions are a challenging subset in percutaneous coronary interventions (PCI). The selection of the type of drug-eluting stents (DES) and the technique for stent implantation have not been clarified.
- Trial name
- Z-SEA-SIDE (NCT01200693)
- Testing
- Sirolimus eluting stent, Everolimus eluting stent, Zotarolimus eluting stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Catholic University of the Sacred Heart
Diabetes Mellitus, Percutaneous Coronary Intervention
The Titan Versus Everolimus Intracoronary Stent (Xience V) in Diabetic Patients
Even though the safety of drug eluting stents has been long established, in roughly 25% o patients their implantation is not considered, for specifically clinical reasons (chronic anticoagulation, bleeding, etc…), which make…
- Trial name
- TITANIC-XV (NCT01510509)
- Testing
- Titanium bare metal stent (Titan2®), Everolimus Drug Eluting Stent (Xience-V®)
- Where
- 8 sites in Finland, Spain
- Sponsor
- Hospital Universitario Infanta Cristina
Coronary Artery Disease
Korean Nationwide Multicenter Pooled Registry of Drug-Eluting Stents
The objective of this study is to evaluate the long-term efficacy and safety of coronary stenting with the various types of drug-eluting stents (DES) and to determine clinical device and procedural success during commercial use…
- Trial name
- Grand-DES (NCT03507205)
- Testing
- Biomatrix; Biomatrix Flex; Nobori, Xience Prime, Xience V/Promus; Cypher
- Where
- 37 sites in South Korea
- Volunteers
- 17,286 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
IVUS-guided DES Implantation in Coronary Calcification
Coronary calcified lesion is associated with a poor clinical outcome. Intravascular ultrasound (IVUS) provides anatomic information in detail about reference vessel dimensions and lesion characteristics including severity of…
- Trial name
- ULTIMATE IV (NCT05800002)
- Testing
- Intravascular ultrasound, Angiography
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ischemic Heart Disease, Coronary Atherosclerosis
Stress-MRI Assessment After Right Coronary Artery CTO Recanalization
The hypothesis of this study is that Stress-MRI is a clinically significant method of myocardial perfusion assessment after coronary angioplasty with stenting of right coronary artery (RCA) chronic total occlusion (CTO) is…
- Conditions
- Ischemic Heart Disease, Coronary Atherosclerosis, Coronary Artery Disease, Coronary Artery Stenosis
- Trial name
- NCT02769650
- Testing
- CTO coronary angioplasty, Optimal medicamentous treatment, Stress-MRI
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atherosclerosis, Coronary Artery Disease
NG PROMUS Stent System for the Treatment of Atherosclerotic Coronary Lesions
NG PROMUS: A Prospective, Multicenter Trial to Assess the NG PROMUS Everolimus-Eluting Platinum Chromium Coronary Stent System (NG PROMUS Stent System) for the Treatment of Atherosclerotic Lesion(s)
- Trial name
- NCT01703000
- Testing
- Percutaneous coronary intervention (NG PROMUS)
- Where
- 9 sites in Australia, New Zealand and 1 more
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Myocardial Ischemia
A Clinical Evaluation of the ProNOVA XR Polymer Free Drug Eluting Coronary Stent System
The objective of this study is the assessment of the performance, safety and efficacy of the ProNOVA XR Polymer Free Drug Eluting Stent System in the treatment of patients with de novo native coronary artery lesions.
- Trial name
- EURONOVA (NCT01151033)
- Testing
- Drug Eluting Stent implantation
- Where
- 3 sites in Poland
- Volunteers
- 50 people
- Sponsor
- KCRI
Incidence of Major Adverse Cardiac Events
Registry Experience at the Washington Hospital Center With Drug Eluting Stents - Synergy
To compare the incidence of major adverse cardiac events among a series of patients receiving the Synergy drug-eluting stent with bioabsorbable polymer to historical controls who have received the Promus Premier drug-eluting…
- Trial name
- NCT02823730
- Testing
- PCI with Synergy Stent
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Medstar Health Research Institute