Clinical trials: Drug Eluting Stents
Coronary Artery Disease, Stent Thrombosis
Optimal Duration of Dual Antiplatelet Therapy After Drug-eluting Stent Implantation
To compare treatment with aspirin alone versus the combined antiplatelet treatment aspirin and clopidogrel after 12 months of combined antiplatelet treatment following drug-eluting stent (DES) implantation.
- Conditions
- Coronary Artery Disease, Stent Thrombosis, Myocardial Ischemia
- Trial name
- OPTIDUAL (NCT00822536)
- Testing
- Aspirin and Clopidogrel, Aspirin
- Where
- France
- Volunteers
- 1,798 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, DCB
DCB vs. DES in Bifurcation Coronary Lesions
This is an investigator-driven prospective, multicentric, international, randomized clinical study, in an open-label randomized fashion, where patients with bifurcation coronary artery disease (Medina: 111,101,011,001) in vessels…
- Trial name
- PICCOLETO V (NCT06551662)
- Testing
- Paclitaxel drug-coated balloons, Sirolimus drug-coated balloons, New generation drug-eluting stent
- Where
- 17 sites in Italy, Poland and 2 more
- Volunteers
- 321 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Acute Coronary Syndrome
Coronary Flow Reserve in Patients With Bio-active Stent or Everolimus-eluting Stent Implanted in Acute Coronary Syndrome
The aim of the trial is to assess coronary artery reactivity using adenosine-induced coronary flow reserve (CFR) by transthoracic echocardiography in patients with Bio-active stent (BAS) and Everolimus-eluting stent (EES) distal…
- Trial name
- BASE-CFR (NCT01080872)
- Testing
- CFR
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
Stenosis in Saphenous Vein Graft, Drug Eluting Stent
Comparison of Safety and Efficacy of Two Different Drug Eluting Stents Implanted Into Saphenous Vein Grafts
Drug eluting stents significantly reduced the rate of in-stent restenosis in coronary arteries. There are several kinds of DES i.e. eluting the drug either from stable or biodegradable polymer.
- Trial name
- NCT00766129
- Testing
- Taxus stent implantation, Luc-Chopin stent
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Disease
Intravascular Optical Coherence Tomography Imaging - Length of Anti-Platelet Therapy After Drug Eluting Stent Placement
Patients who receive drug-coated stents (as opposed to the less frequently used bare metal stents) are currently recommended aspirin plus a thienopyridine such as Plavix, Effient, or Ticlid for one year.
- Trial name
- FDI-DAPT-ZES (NCT01219894)
- Sponsor
- Emory University
Diabetes Mellitus
Comparison of Coronary Xience V and the Cypher Select+ Stents in Diabetic Patients
In stent neointimal hyperplasia may be less in the Cypher select plus stent compared to the Xience V stent in diabetic patients.
- Trial name
- DIABEDES IV (NCT00552994)
- Testing
- Cypher Select plus, Xience V stent
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Shockwave IVL + DES
The objective of this clinical investigation is to evaluate, in a controlled setting, the 12 months safety and efficacy of the combination of Shockwave Intravascular Lithotripsy and a polymer coated Drug Eluting Stent device, for…
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Calcifications Vascular
- Trial name
- Shockwave DES (NCT05291247)
- Testing
- Peripheral lithotripsy system (Shockwave Medical)
- Where
- 6 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Marc Bosiers, MD
Coronary De-novo Stenoses
Efficacy of the SeQuent®Please in the Treatment of De-novo Stenoses Versus Taxus™Liberté™
The aim of the trial is to assess the efficacy of the Paclitaxel-coated SeQuent®Please angioplasty balloon in the treatment of stenoses in native coronary arteries compared to a drug eluting stent.
- Trial name
- PEPCAD-DEBonly (NCT01084408)
- Testing
- SeQuent®Please (Paclitaxel coated balloon), Taxus™Liberté™ (Paclitaxel eluting stent)
- Where
- 2 sites in Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital, Saarland
Coronary Artery Disease, Coronary Heart Disease
Comparison of the Angiographic Result of the Orsiro Hybrid Stent With Resolute Integrity Stent
The purpose of this multicenter, randomized, open label, parallel arm study whether the newest 3rd generation stent - Orsiro hybrid sirolimus-eluting stent is noninferior to the newest 2nd generation stent - Resolute Integrity…
- Conditions
- Coronary Artery Disease, Coronary Heart Disease, Stable Angina, Unstable Angina
- Trial name
- ORIENT (NCT01826552)
- Testing
- Osiro Hybrid Drug-Eluting Stent, Resolute Integrity
- Where
- 8 sites in South Korea
- Volunteers
- 372 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Myocardial Infarction
Paclitaxel Eluting Balloon After Bare Metal Stent Implantation vs. Drug-Eluting Stent in St Elevation Myocardial Infarction
Study objective is the evaluation of safety and efficacy at 12 months of the combination treatment of bare metal Stent plus Paclitaxel Eluting Balloon vs drug eluting stent in patients with ST-elevation myocardial infarction with…
- Trial name
- PEBSI-2 (NCT03610347)
- Testing
- Bare metal Stent plus Paclitaxel Balloon, Drug Eluting Stent
- Where
- 16 sites in Spain
- Volunteers
- 199 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Atherosclerotic Coronary Artery Disease
An Observational Safety Evaluation of Patients Treated With the NEVO™ Sirolimus-eluting Coronary Stent. (NEVO II)
As a result of the implementation of Protocol Am3.0, the design and objective of the NEVO II trial were changed to focus on the safety follow-up of the 103 NEVO™ subjects.
- Trial name
- NEVO II (NCT01202058)
- Testing
- NEVO™ Sirolimus-eluting Coronary Stent System, XIENCE V®/XIENCE PRIME™/PROMUS® Everolimus-eluting Coronary Stent System)
- Where
- 3 sites in Netherlands, Spain and 1 more
- Volunteers
- 156 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease
Pilot Evaluation Of CORACTO® (THE PILOT-SECRET TRIAL)
The purpose of this study is to evaluate the safety and effectiveness of the CORACTO® (Rapamycin®-Eluting coronary stent delivery system) for the treatment of up to two de novo lesions or restenotic post-PTCA (non-stented)…
- Trial name
- PILOT-SECRET (NCT02076516)
- Testing
- Drug-eluting stent: CORACTO®
- Where
- 5 sites in Belgium, France and 2 more
- Volunteers
- 100 people
- Sponsor
- Alvimedica
Coronary Artery Disease
GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions
The objective of this study is to compare the Cypher Select-TM Sirolimus Eluting Stent (SES) with the SONIC-TM Bare Metal Stent (BMS) in the treatment of Chronic Total Occlusion lesions (CTO).
- Trial name
- NCT00220558
- Testing
- Coronary placement of bare metal stent vs. drug eluting stent
- Where
- 14 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Società Italiana di Cardiologia Invasiva
Acute Coronary Syndrome
Researches of Retinal Artery Lesions and Acute Coronary Syndrome
This study is to investigate the relationship between staging of retinal artery lesions and the prognosis of acute coronary syndrome (ACS) in a Chinese population.
- Trial name
- REACS (NCT02415452)
- Testing
- drug-eluting stent implantation
- Volunteers
- 660 people
- Sponsor
- Capital Medical University
Brachiocephalic Vein Stenosis
Biomimetic Stent and Drug Eluting Balloon to Treat Recurrent Cephalic Arch Stenosis
The study evaluates the use of a biomimetic stent (SUPERA®) and a drug eluting balloon (DEB - Passeo 18 Lux) for the treatment of recurrent and tight cephalic arch stenosis in patients with brachiocephalic fistulas.
- Trial name
- Arch-V (NCT03891693)
- Testing
- Passeo-18 Lux and SUPERA® stent
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Singapore General Hospital
Peripheral Arterial Disease Below The Knee
Investigating the Safety and Clinical Performance of Seven iVascular Devices for Endovascular Intervention in the Popliteal and/or Infrapopliteal Arteries
The rationale of this study is to confirm and support the clinical safety and performance of the Oceanus 14pro, Oceanus 18 and Oceanus 35 Balloon Catheters, the Luminor 14m and Luminor 18 Drug Coated Balloons, the Angiolite BTK…
- Trial name
- POP-BTK (NCT05267548)
- Where
- 8 sites in Belgium
- Volunteers
- 143 people
- Sponsor
- iVascular S.L.U.
Dyslipidemia, Coronary Heart Disease
Observational Study to Estimate the Rates of Outcomes in Patients Undergoing Percutaneous Coronary Intervention (PCI) With Drug Eluting Stent (DES) Implantation Who Take Statins
To estimate the rates of percutaneous coronary intervention (PCI) outcomes in patients after drug-eluting stents implantation who take statins.
- Trial name
- OPTIMA (NCT01047176)
- Where
- Russia
- Volunteers
- 602 people
- Sponsor
- AstraZeneca
Femoropopliteal Disease
IntravasCular Imaging-Guided Versus AngiogRaphy-GUided Drug-Eluting Stent Implantation for Fermoropopliteal Artery Disease
Objectives: 1) To evaluate the feasibility of using intravascular ultrasound to assess lesion morphology, select an appropriate stent size and landing zone 2) To compare the primary patency rates after intra vascular…
- Trial name
- ICARUS (NCT05805280)
- Testing
- intravascular ultrasound-guided group, angiography-guided group
- Where
- 8 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease (CAD)
BASel Kosten-Effektivitäts-Trial: Drug-coated BALLoon (DCB) vs. Drug-eluting Stent (DES) Strategy in High-risk Patients With Coronary Artery Disease (CAD)
The main objective of this randomized, multicenter, international, open-label clinical trial is to demonstrate that, in the context of percutaneous coronary intervention for complex coronary artery disease, a SeQuent® SCB…
- Trial name
- BASKET BALL (NCT07363161)
- Testing
- PCI
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 2,184 people
- Sponsor
- B. Braun Melsungen AG
Acute Coronary Syndrome
Vascular Healing After Deployment of Titanium-nitride-oxide-coated OPTIMAX™ Stent and PROMUS-ELEMENT™ Everolimus-Eluting Stent
The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent stent and Promus-Element™ everolimus-eluting stent in patients with…
- Trial name
- TIDES-OCT (NCT02280720)
- Testing
- Stenting using Optimax™, Stenting using PROMUS Element™ Plus
- Where
- 4 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta