Clinical trials: Drug Interaction Study
Hypertension, Dyslipidemia
A Randomized, Open-label, Two-arm, Two-period, Multiple-dose, Study to Evaluate Pharmacokinetic Drug-drug Interaction, Safety and Tolerability of UIC202601 and UIC202602 in Healthy Volunteers
A Randomized, Open-label, Two-arm, Two-period, Multiple-dose, Study to Evaluate Pharmacokinetic Drug-drug Interaction, Safety and Tolerability of UIC202601 and UIC202602 in Healthy Volunteers
- Trial name
- NCT07682948
- Testing
- Investigational Product 1, Investigational Product 2, Investigational Product 1 + Investigational Product 2
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Healthy Male Volunteers
Pharmacokinetic Drug Interactions Between HGP1607 and HGP1501
A Randomized, Open-label, Crossover Study to Investigate the Pharmacokinetic drug interactions and the Safety between HGP1607 and HGP1501 in Healthy Male Volunteers
- Trial name
- NCT03089112
- Testing
- HGP1607, HGP1501, HGP1607+HGP1501
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Bacterial Infections
P1, DDI & MAD PK and Safety Study of Xeruborbactam Oral Prodrug in Combo With Ceftibuten in Healthy Participants
A Phase 1, Open-Label, Drug-drug Interaction, and Randomized, Double-blind, Controlled, Multiple-dose Pharmacokinetics and Safety Study of Xeruborbactam Oral Prodrug (QPX7831) in Combination with Ceftibuten in Healthy Adult…
- Trial name
- NCT06079775
- Testing
- Xeruborbactam Oral Prodrug, Ceftibuten
- Where
- Australia
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Qpex Biopharma, Inc.
Healthy Adult Subjects
Study to Investigate the Interaction Between FG-4592 and Rosiglitazone in Healthy Adult Subjects
The primary purpose of this study is to assess the effect of multiple doses of FG-4592 on the plasma pharmacokinetic of rosiglitazone in healthy adult subjects.
- Trial name
- NCT01376063
- Testing
- FG-4592
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kyntra Bio
Ileostomy - Stoma
Cocoa Ileostomy Study
There is substantial interest in the potential role of chocolate and its primary bioactive component; flavan-3-ol, (-)-epicatechin, in both the prevention and management of cardiovascular disease (CVD).
- Trial name
- NCT03765606
- Testing
- Cocoa Flavanol beverage mix, De-xanthinated Cocoa Flavanol beverage mix
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy Volunteers
Drug-drug Interaction Study of CTP-543 and Oral Contraceptives in Healthy Female Subjects
This is a Phase 1, fixed sequence, multiple dose, open-label study of the effect of CTP-543 on oral contraceptive pharmacokinetics in healthy female subjects.
- Trial name
- NCT04309643
- Testing
- CTP-543, Combined oral contraceptive containing Ethinyl estradiol (EE) and Levonorgestrel (LNG)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals
Healthy Subjects
A Study of IBI351 in Healthy Subjects
This is an open-label, two-cycle clinical study to evaluate the drug interaction between itraconazole or dextromethorphan and IBI351 in healthy subjects.
- Trial name
- NCT05699993
- Testing
- Itraconazole, IBI351, Dextromethorphan
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Healhty
Drug-drug Interaction Study Between UIC202304, and UIC202305
A randomized, open-label, two-sequence, two-period, multiple-dose, study to evaluate pharmacokinetic drug-drug interaction, safety and tolerability of UIC202304 and UIC202305 in healthy volunteers.
- Trial name
- NCT07735052
- Testing
- UIC202304 and co-administration of UIC202304 and UIC202305, UIC202305 and co-administration of UIC202304 and UIC202305
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Macular Degeneration
Study Of The Repeat Dosing Of Ketoconazole On The Pharmacokinetics Of A Single Dose Of Pazopanib (GW786034) Eye Drops
This is a two-period study to evaluate the effect of repeat oral dosing of ketoconazole on the pharmacokinetics of single dose pazopanib administered as an eye drop
- Trial name
- NCT00659555
- Testing
- pazopanib eye drops, Ketoconozole tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteer Study
Drug-drug Interaction Study of Ruzasvir and Bemnifosbuvir
Drug-drug interaction study of Ruzasvir and Bemnifosbuvir
- Trial name
- AT-527 (NCT05731843)
- Testing
- Cohort 1 BEM + Ruzasvir, Cohort 2 Ruzasvir + BEM
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Hot Flashes
A Study of the Pharmacokinetics of Black Cohosh
Black cohosh is a natural supplement that has been used to treat and prevent menopausal symptoms. Remifemin is a standardized form of black cohosh.
- Trial name
- NCT00068185
- Testing
- Black cohosh
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Healthy Volunteers
A Study to Assess the Effect of Abiraterone (JNJ-589485) on the Pharmacokinetics of Pioglitazone Following Administration of Abiraterone Acetate (JNJ-212082) and Pioglitazone HCl Tablets in Healthy Male Participants
The purpose of this study is to evaluate the effects of abiraterone on the pharmacokinetics (study of what the body does to a drug) of pioglitazone when coadministered with abiraterone acetate in healthy adult male participants.
- Trial name
- NCT01873001
- Testing
- Pioglitazone HCl, Abiraterone acetate
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Volunteers
A Study to Investigate the Drug-Drug Interactions of Brivaracetam and Ethanol in Healthy Male Subjects
To evaluate if Brivaracetam (BRV) influences the psychomotor and cognitive impairing effects of Ethanol
- Trial name
- NCT01710670
- Testing
- Brivaracetam, Ethanol
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UCB Pharma SA
Life Experiences, Respiratory Function
Validation of Study in Respiratory Physiology and it Interactions
The aim of the study was to validate tools of physiological signal processing and interpretation on healthy human volunteers in order to improve the understanding in respiratory physiology and its interactions with heart…
- Conditions
- Life Experiences, Respiratory Function, Cardiac Function
- Trial name
- ValApPhI (NCT01881945)
- Testing
- Non-invasive physiological signal recording on healthy volunteer
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Volunteers
TAK-438_110 Drug Interaction With Cytochrome P450 3A4 (CYP3A4) Inhibitor Clarithromycin
The purpose of this study is to evaluate the effect of multiple oral doses of clarithromycin on the pharmacokinetics of TAK-438 and its metabolites in healthy male adult participants following a single oral dose of TAK-438.
- Trial name
- NCT02774902
- Testing
- TAK-438, Clarithromycin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Volunteers
A Food-Effect, Drug-Drug Interaction, and Pharmacokinetics Study of NX-5948 in Healthy Adult Subjects
This is a Phase 1, 2-part double-blinded (with respect to NX-5948/placebo), placebo-controlled study. Part 1 is a randomized, 3 period cross-over food-effect (FE) and drug-drug interaction (DDI) study.
- Trial name
- NCT06593457
- Testing
- IP
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Nurix Therapeutics, Inc.
Infection, Human Immunodeficiency Virus I
A Drug Interaction Study Evaluating Plasma GSK2248761 and GSK1349572 Pharmacokinetics in Healthy Adult Subjects.
This is a single-center, open-label, three-period, fixed-sequence cross over study in healthy adult subjects. A total of approximately 16 healthy subjects will be enrolled to provide data from 12 evaluable subjects.
- Trial name
- NCT01283100
- Testing
- GSK1349572, GSK2248761
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy
Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers
This study aims to evaluate the pharmacokinetic interaction between tegoprazan and combination of metronidazole, tetracycline and bismuth in healthy adult volunteers.
- Trial name
- NCT04066257
- Testing
- Tegoprazan, Metronidazole, Tetracycline
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Hypertension
Longitudinal Follow-up Study in Two Chinese Hypertension Cohorts
Essential hypertension is a complex trait that results from interaction between environmental factors and genetic factors. Salt sensitivity is the genetic susceptibility of blood pressure to salt, and it is an intermediate…
- Trial name
- NCT04471389
- Testing
- Incidence and risk factors of hypertension
- Where
- China
- Volunteers
- 5,611 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Methamphetamine Dependence
Ph1 Lobeline Interaction Study - 1
The purpose of this study is to determine if there are significant cardiovascular or other interactions between sublingual lobeline and intravenous methamphetamine.
- Trial name
- NCT00439504
- Testing
- Lobeline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
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