Clinical trials: Drug Interactions
Healthy
A Drug Interaction Study of SPD503 and Vyvanse Administered Alone and In Combination in Normal Healthy Volunteers
Drug-drug interaction study; to examine the pharmacokinetics of SPD503 and VYVANSE (lisdexamfetamine dimesylate) when given alone, and in combination.
- Trial name
- NCT00919867
- Testing
- SPD503, VYVANSE, SPD503 and VYVANSE
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shire
HIV, Prophylaxis
Cabotegravir-Hormone PK/PD Interactions for HIV Prevention
This is a research study to better understand how long-acting cabotegravir (CAB-LA) works to prevent HIV in people. This study will also evaluate the impact of endogenous and therapeutic hormones on CAB-LA pharmacology.
- Conditions
- HIV, Prophylaxis, Injectable
- Trial name
- CHIPP-PrEP (NCT07672717)
- Testing
- Cabotegravir Injectable Suspension (CAB LA)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy Female Volunteers
A Study to Evaluate the Drug-drug Interaction of BMS-986196 With Oral Contraceptives in Healthy Female Participants
The purpose of this study is to evaluate the effect of BMS-986196 when coadministered with combined hormonal oral contraceptives (ethinyl estradiol [EE] and norethindrone [NET]) in healthy female participants.
- Trial name
- NCT05891262
- Testing
- BMS-986196, Loestrin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Helicobacter Pylori Infection
Drug-Drug Interactions Between TNP-2198 and Midazolam, Clarithromycin
This is a single center, open label, drug-drug interaction, Phase 1 study of TNP-2198 in approximately 32 healthy participants, includes 2 cohorts (16 participants per cohort): Midazolam cohort and Clarithromycin cohort.
- Trial name
- NCT06551623
- Testing
- Midazolam, Clarithromycin, TNP-2198
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics Inc.
HIV Infections
A Study to Investigate the Potential Drug-Drug Interaction Between VH4524184 and Oral Contraceptive (Loestrin) in Healthy Adult Female Participants
This study aims to assess any impact of VH4524184 on the pharmacokinetic (PK) profile of an ethinyl estradiol (EE) and norethindrone acetate (NEA) containing oral contraceptive (OC) administered to healthy adult female…
- Trial name
- NCT06310616
- Testing
- VH4524184, Loestrin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy
A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants
This is an open-label, 2-cohort study to evaluate the mutual DDI potential between denifanstat and resmetirom in healthy adult participants.
- Trial name
- NCT07216313
- Testing
- Denifanstat, Resmetirom
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sagimet Biosciences Inc.
Healthy
A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Aluvia
Azvudine(FNC)，a nucleoside reverse transcriptase inhibitor, make itself a better candidate to be co-formulated in other anti-HIV therapies, thus to improve patient's compliance.
- Trial name
- NCT07002242
- Testing
- Azvudine tablets(FNC) and Aluvia, Azvudine tablets(FNC), Aluvia
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henan Genuine Biotech Co., Ltd.
Healthy
Investigation of Potential Drug-drug Interactions Between Faldaprevir and the Immunosuppressant Drugs Cyclosporine or Tacrolimus
The primary objective of this trial is to investigate the effect of multiple-dose faldaprevir (FDV) on the single-dose pharmacokinetics of cyclosporine or tacrolimus
- Trial name
- NCT02016625
- Testing
- Faldaprevir, Cyclosporine, Tacrolimus
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pharmacokinetic
Drug-drug Interaction Study to Evaluate the Effect of Omeprazole on CG5503 (Tapentadol)
This was a single center, open-label, two-way crossover, drug-drug-interaction study to determine the effect of multiple dosing of omeprazole on 4 consecutive days on the pharmacokinetics of a single dose of an immediate-release…
- Trial name
- NCT03979989
- Testing
- Tapentadol IR capsule, Omeprazole capsule
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Healthy
Pharmacokinetic Drug Interaction Between Revaprazan and Itopride HCl in Healthy Male Subjects
To evaluate drug-drug interaction
- Trial name
- NCT01332890
- Testing
- Sequence 1, Sequence 2, Sequence 3
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
HIV, Depression
Pharmacokinetic Drug-drug Interaction Study Between RaltEgravir and CITALopram in Healthy Subjects (RECITAL).
Depression is the most common mental health disorder among HIV-patients. Recognizing and treating depression is important in order to improve quality of life and health outcomes in those living with HIV.
- Trial name
- RECITAL (NCT01978782)
- Testing
- raltegravir, citalopram
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy Volunteer
Neural Mechanisms of Emotion-behaviour Interactions
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities.
- Trial name
- EMOBB (NCT07623746)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Tumor
Drug-drug Interaction Study Between Fluconazole and Famitinib in Healthy Subjects
An open-label, fixed-sequence, drug-drug interaction study to evaluate the effects of fluconazole on the pharmacokinetics and safety of famitinib in healthy subjects.
- Trial name
- NCT05147727
- Testing
- Fluconazole、Famitinib
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Depression, Pain
Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study
The purpose of the study is to examine the connection between the dose of paroxetine and the effect of paroxetine on tramadols metabolism and thereby the effect of tramadol on the median pupil size.
- Trial name
- NCT00785603
- Testing
- Paroxetine, Tramadol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Healthy
A Drug-Drug Interaction Study Between Fenofibric Acid and Efavirenz
Efavirenz is predominantly metabolized by cytochrome P450 (CYP) 2B6. Fenofibric Acid is an inhibitor of CYP2B6. This study will evaluate the effect of multiple doses of fenofibric acid at steady-state on the pharmacokinetics of…
- Trial name
- NCT01472380
- Testing
- efavirenz, fenofibric acid 105 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Purpura, Thrombocytopenic, Idiopathic
Drug-drug Interaction Study of Eltrombopag and Cyclosporine in Healthy Subjects
A drug-drug interaction study between eltrombopag and cyclosporine is being conducted to support the use of these drugs together in subjects, such as those with severe aplastic anemia or immune thrombocytopenia purpura.
- Trial name
- NCT02281370
- Testing
- Eltrombopag, Cyclosporine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Participants
A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Rosuvastatin in Healthy Participants
The purpose of the study is to assess the effect of capivasertib on the pharmacokinetics (PK) of oral rosuvastatin in healthy participants.
- Trial name
- NCT07088913
- Testing
- Capivasertib, Rosuvastatin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Influence of CYP2C19 Genotype on the Pharmacokinetics (PK) of Voriconazole
The purpose of this study is to: Evaluate the influence of CYP2C19 genotype on PK profiles of voriconazole.
- Trial name
- NCT00942773
- Testing
- Voriconazole
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cholestasis
Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects
In participants with inadequate response/intolerance to ursodeoxycholic acid (UDCA) taking obeticholic acid (OCA) who experience pruritus (due to primary biliary cholangitis [PBC], OCA, or both) the addition of linerixibat to OCA…
- Trial name
- NCT04053023
- Testing
- GSK2330672 (linerixibat), Obeticholic acid
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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