Clinical trials: Drug Use
Cardiac Arrest, Cardiopulmonary Arrest
Use of a Feedback Device to Limit Too Shallow Compressions Associated With the Use of an I-gel® Device
Airway management in out-of-hospital cardiac arrest is still debated. Several options exist: bag-valve-mask ventilation, supraglottic devices and endotracheal intubation.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation, Emergency Medicine
- Trial name
- NCT05709613
- Testing
- Use of a chest compressions' feedback device
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Health-Related Quality-of-Life, Social Capital
Cocreating Action to Improve Rationality in the Health System
Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination).
- Conditions
- Health-Related Quality-of-Life, Social Capital, Health Literacy, Community Based Participatory Research
- Trial name
- CAIR (NCT07237971)
- Testing
- Cocreation process
- Where
- 2 sites in Spain
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Opioid-use Disorder, Medication Assisted Treatment
Minds and Mentors Program (MiMP)- R61
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of a twelve- week mindfulness based relapse prevention protocol in combination with peer mentoring in…
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
- Trial name
- MiMP (NCT04233671)
- Testing
- Mindfulness based relapse prevention and peer mentoring
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Nicotine Dependence, Other Tobacco Product
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1
This study is to examine if inhaled doses of menthol that produce low and high cooling effects change the appeal of e-cigarettes containing low and high doses of nicotine in adolescent smokers.
- Trial name
- NCT02179034
- Testing
- Nicotine, Low Dose Menthol, High Dose Menthol
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Yale University
Medication Adherence
Study to Test the Efficacy of Online Education to Increase Safe Use of Opioid Medication.
The purpose of this project is to test whether an online pain medication intervention is a feasible and effective way to increase opioid pain medication safety.
- Trial name
- NCT01770314
- Testing
- Experimental
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Inflexxion, Inc.
Prescription Drug Abuse (Not Dependent), Substance Use
Preventing Prescription Drug Abuse in Middle School Students
This project is designed to test a primary prevention approach to the problem of prescription drug misuse and abuse (PDA) among middle school students.
- Conditions
- Prescription Drug Abuse (Not Dependent), Substance Use, Substance Abuse
- Trial name
- MSPDA (NCT03129334)
- Testing
- LST Middle School Online
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Photoaging, Actinic Keratosis
5fluorouracil for Advanced Photoaging
It is well known the efficacy of 5% 5-fluoruracil for multiple and superficial actinic keratosis (AKs)treatment. Recently its additional benefit for advanced and severe photoaging while treating Aks was reported.
- Trial name
- NCT01405144
- Testing
- 5-fluoruracil
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Performance Enhancing Product Use, Physical Fitness
Effect of Hyperbaric Oxygen Therapy
The goal of this tudy will be to investigate the effects of a single session of hyperbaric oxygen therapy (HBOT) on recovery and performance after a football match in elite youth football players.
- Conditions
- Performance Enhancing Product Use, Physical Fitness, Recovery, Sport
- Trial name
- NCT06112210
- Testing
- HBOT group, CON group
- Where
- Serbia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Nicotine Withdrawal, Nicotine Addiction
Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers
The purpose of the present study is to examine the pharmacokinetics and pharmacodynamics of "tobacco-free" oral nicotine pouches, at various doses and flavors, in healthy adult smokers.
- Conditions
- Nicotine Withdrawal, Nicotine Addiction, Drug Effect
- Trial name
- NCT05335915
- Testing
- Nicotine, Cigarette
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Smoking, Tobacco Use
Testing Counseling Styles to Motivate Smokers to Quit
The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.
- Conditions
- Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT01188018
- Testing
- Brief Advice (BA), Motivational Interviewing (MI), Health Education (HE)
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Pregnancy Complications, Herbal Medicine Adverse Reaction
Silver Leaf During Pregnancy in French Guiana : Use and Impact on Health
This is a descriptive, observational, cross-sectional study among women who have given birth in one of French Guiana's maternity hospitals to determine if the use of silver leaf is frequent and could have an impact on pregancy…
- Trial name
- Feydarjan (NCT06538753)
- Where
- French Guiana
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Alcohol Drinking, Tobacco Use
Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS.
- Conditions
- Alcohol Drinking, Tobacco Use, Drug Use
- Trial name
- NCT05380765
- Testing
- Native PATHS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Agitated; State, Acute Reaction to Stress, Agitation,Psychomotor
Mindful Melody: Feasibility of Implementing Music Listening on an Inpatient Psychiatric Unit and Its Relation to the Use of As Needed Medications for Acute Agitation
In this quality improvement project, our objectives were to assess the feasibility and effectiveness of using music as an adjunct to or replacement of pharmacological interventions for patient agitation on an inpatient…
- Trial name
- NCT04514432
- Testing
- Music
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Smoking
Reduced Exposure Study Using the CHTP 1.2 With 5 Days in a Confinement Setting Followed by 85 Days in an Ambulatory Setting.
The overall goal of the study is to demonstrate reduction in the levels of biomarkers of exposure (BoExp) to selected harmful and potentially harmful constituents (HPHCs) identified in cigarettes and to obtain safety information…
- Trial name
- NCT02641587
- Testing
- CHTP 1.2, CC
- Where
- Poland
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Narcotic Abuse, Opioid-related Disorders
Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo
This was a single-dose, randomized, double-blind, placebo-controlled, 3 way crossover study designed to evaluate the relative abuse potential of crushed EMBEDA® compared to morphine sulfate CR tablets and placebo in healthy male…
- Conditions
- Narcotic Abuse, Opioid-related Disorders, Analgesia, Chronic Pain
- Trial name
- NCT01595867
- Testing
- EMBEDA - morphine sulfate/ naltrexone hydrochloride, morphine sulfate CR crushed.
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pfizer
Reintegration Difficulties, Suicidal Ideation and Behaviors
Expanding Veteran Sponsorship Initiative+ to Support High-Risk Transitioning Servicemembers and Veterans: A Precision Medicine Approach
Background Young Veterans in the U.S. face a heightened risk of suicide, particularly during the first year after leaving military service-a period often referred to as the "deadly gap." Suicide rates among Veterans aged 18 to 34…
- Conditions
- Reintegration Difficulties, Suicidal Ideation and Behaviors, Health, Connectedness
- Trial name
- NCT07356492
- Testing
- Onward Ops- receive peer sponsor and community support, VA stepped care services
- Where
- United States
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Drug Use
Bioequivalence Study of 20 mg Omeprazole Capsules in Indonesia Healthy Subject
The study was conducted to investigate whether 20 mg omeprazole capsules manufactured by PT. Dankos Farma for PT. Hexpharm Jaya is bioequivalent to its reference product, 20 mg Losec® capsules manufactured by AstraZeneca AB…
- Trial name
- NCT05849883
- Testing
- Omeprazole 20 mg Capsules
- Where
- Indonesia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- PT Kalbe Farma Tbk
Recreational Drug Use
A Study to Evaluate the Intranasal Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users (PF614-103)
The purpose of this study is to examine the abuse potential and pharmacokinetics of PF614 compared with a non-abuse deterrent, commercially available, immediate release (IR) oxycodone hydrochloride (HCl) formulation and placebo.
- Trial name
- NCT05567354
- Testing
- PF614, Oxycodone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences