Clinical trials: Drug Use Disorder
Dementia, Potentially Inappropriate Medication Use
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational…
- Conditions
- Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
- Trial name
- e-ALIGN (NCT07454824)
- Testing
- e-ALIGN Patient-Portal Deprescribing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Marijuana Use
Project Chill: Tailored Youth Drug Intervention In Primary Care
This study examines the impact of tailored computer-delivered and therapist-delivered brief motivations prevention/interventions both for adolescents who have not initiated marijuana use (prevention), and those who use marijuana…
- Trial name
- NCT01329315
- Testing
- BMI-T, BMI-C
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Drug-Related Side Effects and Adverse Reactions
CYP4A11 and CYP4F2 Gene Variants as Makers of Cardiovascular Adverse Events of Non-steroidal Anti-inflammatory Drugs
Randomized, double-blinded, cross-over and placebo controlled clinical trial to evaluate the association between genetic polymorphism of CYP4F2 with cardiovascular adverse effects of non-steroidal anti-inflammatory drugs…
- Trial name
- NCT02779530
- Testing
- Diclofenac
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eduardo Barbosa Coelho
Hepatitis C, Chronic
Direct-acting Antiviral Therapy and Reinfection Among PWID With Chronic HCV in Community-based Settings
SHARP-C is an observational cohort study investigating the effect of direct-acting antiviral (DAA) therapy and reinfection in people with chronic hepatitis C virus (HCV) and recent injecting drug use.
- Trial name
- SHARP-C (NCT03343925)
- Where
- 4 sites in Australia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Pain Management
Usage and Plan of Care Changes Due to Drug Screenings
The purpose of this minimal risk, observational survey is to document the accuracy, benefits, and how qualitative and quantitative results affect patients' plan of care.
- Trial name
- NCT02995278
- Testing
- Does not include a drug needing FDA approval and therefore it is not by definition, a Clinical Drug Trial as defined by FDA.
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Data Collection Analysis Business Management
HIV Infections, Sexually Transmitted Diseases
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic.
- Trial name
- PCORI PrEP (NCT04855773)
- Testing
- PrEPmate, Dot Diary
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Drug Abuse, Alcohol Abuse
Student Athlete Testing Using Random Notification
The purpose of this study is to determine the influence of drug testing on risk and protective factors of substance abuse among adolescents; examine whether drug and alcohol testing among high school athletes leads to reduced…
- Conditions
- Drug Abuse, Alcohol Abuse, Substance Abuse
- Trial name
- SATURN (NCT00451854)
- Testing
- Random, no advanced notice drug and alcohol testing
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse
Youth Substance Use Prevention/Reduction Through Science-based Drug Abuse Education
Our primary goal is to conduct a pilot study of the effects of a new potential strategy for youth substance abuse prevention - science-based drug education integrated into the high school science curriculum.
- Trial name
- NCT00612482
- Testing
- drug prevention curriculum
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Colorectal Cancer
Use and Decision-making About Colorectal Cancer Screening Among Hispanic Men and Women
During this first year, the researchers have worked toward identifying factors influencing initiation of colorectal cancer screening among Hispanic men and women aged 50 and older and developing an intervention plan using…
- Trial name
- NCT00136227
- Testing
- small media intervention using video, flip chart, and pamphlets and a tailored interactive multimedia intervention
- Where
- United States
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol and Other Drug Use Disorders
Texas Family Health Patterns: A Study Across Generations
The researchers are studying factors that may increase the risk for alcohol and drug use in individuals who do not have any problems with these substances.
- Trial name
- NCT02438254
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tobacco Use Disorder, Schizophrenia
Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail
In the present study, we investigate healthy subjects and schizophrenic patients who frequently show very low attentional capacity with functional magnetic resonance imaging (fMRI) and electrophysiology (EEG) during…
- Trial name
- NIKOGEN (NCT00618280)
- Testing
- nicotine nasal spray
- Where
- 2 sites in Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Smoking Cessation; Tobacco Dependence, E-Cig Use
BREATHE Free Curriculum
The purpose of this study is to evaluate whether BREATHE Free, an in-person faith-based smoking cessation program, can help people quit using tobacco products, including cigarettes, cigars, cigarillos, and e-cigarettes/vapes.
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT06862050
- Testing
- BREATHE Free Curriculum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
HIV Infections, Substance Use Disorders
Couples ART Adherence Intervention for PWID in Kazakhstan
The fastest growing HIV epidemics globally are driven by injection drug use, but only a small percentage of HIV-positive people who inject drugs (PWID) have achieved viral suppression.
- Trial name
- NCT03555396
- Testing
- SMART Couples 2, Standard of Care
- Where
- Kazakhstan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Use, Binge Drinking
iSTART: A Campus & Community Initiative for Services in Tec-health
The iSTART intervention is a 30-day substance prevention web-app whereby students complete five weekly interactive modules using a smart device or computer.
- Conditions
- Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking
- Trial name
- iSTART (NCT05362357)
- Testing
- iSTART Web-app
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Substance Use
Interactive Technology for Media Literacy Drug Prevention in Community Groups
This Phase II STTR will evaluate an interactive, self-paced, e-learning media literacy intervention, REAL media, to prevent youth substance use among youth in the 4-H organization.
- Trial name
- NCT03157700
- Testing
- REAL media curriculum
- Where
- United States
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Hypertension;Pulmonary;Primary
Observational Study of Actigraphy in Pediatric Pulmonary Arterial Hypertension
This study plans to learn more about activity levels in children with pulmonary hypertension. Pulmonary hypertension is a condition where the pressure in the lungs is higher than normal. This can affect the person's heart.
- Trial name
- NCT04745000
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anabolic Steroid Overdose, Infertility
Prospective, Longitudinal Study on FItness DOping in DenmarK
The aim of this prospective longitudinal study is to investigate the risks associated with use of anabolic steroids in fitness circles in Denmark in order to assess the scope of therapeutic need existing as a consequence of use.
- Conditions
- Anabolic Steroid Overdose, Infertility, Cardiovascular Complication, Illicit Drug Use
- Trial name
- FIDO-DK/RH (NCT05599438)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Chagas Disease, Trypanosomiasis
BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease
Evaluate if benznidazole, an antiparasite drug, given at a dose calculated as 5mg/kg/day for 60 days, now administered as a fixed daily dose of 300mg during 40 to 80 days of treatment - period adjusted according to the patient's…
- Conditions
- Chagas Disease, Trypanosomiasis, Heart Disease
- Trial name
- BENEFIT (NCT00123916)
- Testing
- Benznidazole
- Where
- 47 sites in Argentina, Bolivia and 3 more
- Volunteers
- 2,854 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Tobacco Dependence
A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users
Cigarette smoking is very common in current and former injection drug users and is known to cause chronic lung diseases. Quitting smoking is proven to improve the health of people addicted to cigarettes. .
- Trial name
- NCT01334736
- Testing
- Usual care, Lung age, Contingency Management
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University