Clinical trials: Drug Use Disorder
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Systemic Arterial Hypertension, Pharmacotherapy
Use of Technology to Optimize Hypertension Treatment in Elderly People in Primary Care
The control of blood pressure (BP) in the elderly is influenced by several factors, among them, the measurement methodology. The measurement of BP in the office is prone to failures, so the use of technology associated with blood…
- Conditions
- Systemic Arterial Hypertension, Pharmacotherapy, Pharmaceutical Care
- Trial name
- MINOR (NCT04861727)
- Testing
- MRPA procedure, Pharmaceutical intervention
- Where
- Brazil
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Adolescent Dysmenorrhea
Adolescent Dysmenorrhea : Prevalence, Severity, Experience and Management in the Use of Medication in High School Girls in Ille-et-Vilaine
Dysmenorrhea or painful menstruation is a common symptom of menses. Dysmenorrhea is defined as a painful, cramping sensation in the lower abdomen or back associated with menstrual periods and is classified into primary and…
- Trial name
- DAPsvs (NCT04007471)
- Testing
- Anonymous survey
- Where
- France
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Nicotine Dependence, Other Tobacco Product
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1
This study is to examine if inhaled doses of menthol that produce low and high cooling effects change the appeal of e-cigarettes containing low and high doses of nicotine in adolescent smokers.
- Trial name
- NCT02179034
- Testing
- Nicotine, Low Dose Menthol, High Dose Menthol
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Yale University
Infections, Rotavirus
Special Drug Use Investigation for ROTARIX®
This study aims to determine the incidence of intussusceptions (IS) (including suspected cases of intussusception) after vaccination with Oral Rotarix® under clinical practice, in Japan.
- Trial name
- NCT01636739
- Testing
- Oral Rotarix®, Data collection
- Volunteers
- 10,982 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acceptance, Social, Sensitivity, Contact
Evaluation of Cutaneous Acceptability and Perceived Effectiveness of a Nasal Spray (Health Care Products)
This is a clinical study for health care product safety assessment. The research is going to conducted with 45 subjects, aged 18 to 70 years, women users of the product category, regardless of color/race, ethnicity, sexual…
- Trial name
- NCT05508230
- Testing
- Hyaluronic Nasal Spray
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Herbarium Laboratorio Botanico Ltda
Smoking, Cigarette, Smoking, Tobacco
Examination of Low Wattage and High Wattage E-Cigarettes
The overall aim of the proposed study is to evaluate the effect of switching from conventional cigarettes to either a LWe or HWe on smoking behavior, product use patterns and continued use, as well as biomarkers of toxicant…
- Conditions
- Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
- Trial name
- SWITCH (NCT03113136)
- Testing
- Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Substance Use, HIV Infections
Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)
This study will test the effects of an intervention to reduce substance use and related harms among people leaving rural jails or otherwise involved in the criminal justice system.
- Conditions
- Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis)
- Trial name
- NCT04134767
- Testing
- Health Linkage, Overdose Education
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- April M Young
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Use Disorder
Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals
Nicotine addiction is a serious health problem in the United States; 46 million people smoke cigarettes, and 70% of those are trying to quit.
- Trial name
- NCT00308763
- Testing
- Nicotine Patch, Sustained Release Bupropion
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Family Planning Services, Substance-Related Disorders
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education…
- Conditions
- Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
- Trial name
- NCT04162184
- Testing
- Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Marijuana Abuse
Evaluating Responses to Drug-Related Cues Versus Neutral Cues to Understand the Effects of Marijuana Craving - 1
The majority of past research on marijuana treatment has specifically targeted the alleviation of withdrawal symptoms. Minimal focus has been placed on how altering craving effects may play a role in treating marijuana addiction.
- Trial name
- NCT00218478
- Testing
- Cue Desensitization
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Healthy, Opioid Use Disorder
Multi-System Analysis of Opioid Receptor Binding
This study will enroll up to 60 adults (including 30 females and 30 males) in three cohorts of up to 20 subjects each. In all three groups, [11C]carfentanil whole-body PET imaging will be used to examine the central nervous…
- Trial name
- NCT05528848
- Testing
- Carfentanil, C-11, Naloxone, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Drug Addiction, Smoking Cessation
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays in the effectiveness of nicotine replacement…
- Trial name
- NCT00390559
- Testing
- nicotine transdermal system, Nicotine containing cigarette
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Depression, Anxiety
Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use
This 3-arm study compares the effectiveness of an (1) 8-week mindfulness-based intervention, MBCT-R (Mindfulness-Based Cognitive Therapy for Resilience During COVID-19)+CHA MindWell vs.
- Conditions
- Depression, Anxiety, Substance Use, Stress, Psychological
- Trial name
- NCT04595084
- Testing
- Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Altitude, Ultraviolet Rays
Ultraviolet Exposure, Antioxidant Use and Skin Erythema at Extreme High Altitude
With the increasing tourism and adventure travel into extreme environments comes the need to reassess the required protection against ultraviolet (UV) radiation and possible other oxidative stresses.
- Conditions
- Altitude, Ultraviolet Rays, Antioxidants, Oxidative Stress
- Trial name
- NCT00685438
- Where
- Nepal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Delinquency, HIV Risk
The ProGirls Study
Girls in the juvenile justice system who have high rates of delinquency, drug abuse, and trauma are particularly at risk for engaging in risky sexual behavior and for contracting HIV/AIDS or other sexually transmitted infections…
- Conditions
- Delinquency, HIV Risk, Substance Use, Trauma Exposure
- Trial name
- NCT02112201
- Testing
- Integrated intervention for parents and adolescent girls
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Opioid-use Disorder, Adherence, Medication
Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania
Investigators will adapt the Brief Social Behaviour and Network Therapy (B-SBNT) intervention developed to facilitate recovery among people receiving medication-assisted treatment for opioid use disorder in the United Kingdom.
- Conditions
- Opioid-use Disorder, Adherence, Medication, HIV Infections
- Trial name
- NCT04479475
- Testing
- Supportive care through community support persons
- Where
- Tanzania
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health