Clinical trials: Duodenal Polyposis
Duodenal Adenomas, Familial Adenomatous Polyposis
CryoBalloon Ablation for Treatment of Duodenal Adenomas
This multicenter prospective non-randomized interventional study (clinical trial) that will assess the safety and efficacy of cryoballoon ablation treatment using the C2 Cryoballoon device (Pentax Medical Corporation) as an…
- Trial name
- C2D2 (NCT03847636)
- Testing
- CryoBalloon ablation
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma
Testing Obeticholic Acid for Familial Adenomatous Polyposis
This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP).
- Conditions
- Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma, Duodenal Carcinoma, Familial Adenomatous Polyposis
- Trial name
- NCT05223036
- Testing
- Biopsy Procedure, Biospecimen Collection, Gastrointestinal Endoscopy
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP)
Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)
RIPAF (Rete Italiana Poliposi Adenomatosa Familiare) is a national, multicenter observational registry designed to establish a coordinated Italian network for the management of Familial Adenomatous Polyposis (FAP) and related…
- Conditions
- Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP), MUTYH-Associated Polyposis (MAP), Non-APC/MUTYH Associated Polyposis (NAMP)
- Trial name
- RIPAF (NCT07461246)
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Duodenum Cancer, Familial Adenomatous Polyposis
Duodenal Polyposis Classification in FAP
Duodenal cancer is the leading cause of cancer-related mortality in patients with familial adenomatous polyposis (FAP), yet the current Spigelman staging system provides limited predictive accuracy for advanced neoplasia.
- Conditions
- Duodenum Cancer, Familial Adenomatous Polyposis, Duodenal Polyposis, Ampulla of Vater Adenoma
- Trial name
- DRACO (NCT07199127)
- Testing
- DRACO
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Adenomatous Polyposis Coli, Familial Adenomatous Polyposis
Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis
The objective of this study is to investigate the feasibility for the treatment of precancerous peri-ampullary FAP polyps in the duodenum using low-thermal argonplasma.
- Conditions
- Adenomatous Polyposis Coli, Familial Adenomatous Polyposis, Duodenal Adenoma
- Trial name
- coldAPC (NCT06435533)
- Testing
- low energy argonplasma coagulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Gastric Polyp, Gastric Neoplasm
Tranexamic Acid During Upper GI Endoscopic Resection Procedures
Endoscopic resection of gastrointestinal lesions may prevent cancer. However, resection is associated with adverse events such as bleeding.
- Conditions
- Gastric Polyp, Gastric Neoplasm, Duodenal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT05688020
- Testing
- Tranexamic acid, Epinephrine injection
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Esophageal Cancer, Gastric Cancer
Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study
Cancers of the upper gastro-intestinal tract, including esophagus (gullet), stomach and small bowel, are amongst the deadliest malignancies.
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus, Gastric Atrophy
- Trial name
- PROSPERO (NCT04843397)
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Familial Adenomatous Polyposes, Duodenal Polyposis
Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP)
Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disorder that predisposes to a number or malignant disorders [1,2].
- Conditions
- Familial Adenomatous Polyposes, Duodenal Polyposis, Duodenal Cancer
- Trial name
- NCT03346980
- Testing
- Esophagogastroduodenoscopy
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Gastrointestinal Neoplasms, Gastrointestinal Disease
Endoscopic Resection Multicenter Registry
This is a retrospective and prospective multicenter registry to collect long-term data (1 year) on patients who have or will undergo Endoscopic resection such as EMR, ESD, EFTR, STER, etc.
- Conditions
- Gastrointestinal Neoplasms, Gastrointestinal Disease, Gastric Cancer, Gastric Neoplasm
- Trial name
- NCT03065257
- Testing
- Endoscopic Resection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Familial Adenomatous Polyposis, Duodenal Neoplasms
Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
Duodenal carcinomas are the leading cause of mortality in patients with Familial Adenomatous Polyposis (FAP) who underwent prophylactic colorectal surgery.
- Conditions
- Familial Adenomatous Polyposis, Duodenal Neoplasms, Duodenal Polyps
- Trial name
- PreDuoFAP (NCT00808743)
- Testing
- Celecoxib, Ursodeoxycholic acid
- Where
- 5 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- Radboud University Medical Center
Duodenal Polyposis
Coxib-inhibition of Duodenal Polyp Growth in FAP
Preliminary data indicate a protective effect on the development of duodenal polyps by coxib treatment. The hypothesis of the present study is that normal therapy doses of rofecoxib for 1 year would stop or reverse the…
- Trial name
- NCT00844727
- Testing
- Rofecoxib
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Oslo University Hospital