Clinical trials: Dupuytren's Contractures
Dupuytren's Contracture
AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture
This was a Phase 3, double-blind, randomized, placebo-controlled study conducted in the United States. Subjects with a diagnosis of Dupuytren's contracture in a metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint…
- Trial name
- CORD-I (NCT00528606)
- Testing
- collagenase clostridium histolyticum
- Where
- 15 sites in United States
- Volunteers
- 308 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren Contracture
Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)
Dupuytren's disease is a progressive disease due to unknown causal agents or genetics. Dupuytren's disease contains nodules and cords in the fascia as the epicenter of disease progression.
- Trial name
- DupuyShock (NCT01184586)
- Testing
- Intervention - ESWT Storz Duolith high energy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Dupuytren Contracture, Dupuytren's Disease of Finger
Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease
Dupuytren's disease is a non-curative, progressive disorder leading to function-impairing deformities of the hand. Although numerous treatments exist, the most common and widely accepted therapy is removal of diseased fascia.
- Trial name
- NCT03000114
- Testing
- Percutaneous Needle Aponeurotomy, XIAFLEX
- Where
- Canada
- Volunteers
- 334 people
- Sponsor
- University of Calgary
Dupuytren Contracture
BOND Study: the Benefit Of Night Splinting in Dupuytrens'
The BOND study is a prospective, randomised single blinded controlled trial to assess the effect of night splinting in patients who have had collagenase injection and manipulation therapy for Dupuytren's Contracture.
- Trial name
- BOND (NCT03031080)
- Testing
- Thermoplastic Hand Splint
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Dupuytren Contracture
The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring
Research is instrumental for improving medical care and the patient experience. Finding new surgical techniques can create better outcomes and minimize recovery time and complications for patients.
- Trial name
- NCT03155854
- Testing
- Pretendinous cord excision, Division/manipulation of the cord
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Dupuytren Disease
Percutaneous Aponeurotomy in the Treatment of Dupuytren's Disease
The efficiency of percutaneous aponeurotomy in the treatment of Dupuytrens disease is well known. However, the duration of the clinical improvement after aponeurotomy is not well known.
- Trial name
- APADUP (NCT02474576)
- Testing
- Percutaneous aponeurotomy
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Dupuytren's Contracture
Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures
The primary objective of this study is to assess the safety of two concurrent injections of AA4500 into the same hand in subjects with multiple Dupuytren's contractures with palpable cords followed 24 to 72 hours later by a…
- Trial name
- NCT01674634
- Testing
- XIAFLEX / XIAPEX
- Where
- 25 sites in United States
- Volunteers
- 715 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease, Dupuytren Contracture
Post-contracture Release Radiation for Dupuytren's Disease
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
- Conditions
- Dupuytren's Disease, Dupuytren Contracture, Dupuytren Disease of Palm and Finger, Dupuytren Disease of Finger
- Trial name
- NCT04122313
- Testing
- Evaluation of Dupuytren's Disease Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Dupuytren&Amp;#39;s Contracture, Dupuytren&Amp;#39;s Fasciectomy
Preoperative Serial Casting, Education, and Therapy for Dupuytren's Contracture
We are running a small study to test whether a special type of therapy - including casting, stretching, and massage - might help improve recovery after Dupuytren's Fasciectomy.
- Conditions
- Dupuytren&Amp;#39;s Contracture, Dupuytren&Amp;#39;s Fasciectomy, Dupuytren&Amp;#39;s Disease
- Trial name
- PRESCET (NCT07024576)
- Testing
- Preoperative casting intervention
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Bournemouth University
Dupuytren's Disease
Registry of Dupuytren's Contracture Treatment Outcomes
Experience with Microbial Collagenase (trade name Xiapex) in Europe currently is limited to randomised controlled studies.While such studies are essential to determine efficacy and safety of the product (usually compared to…
- Trial name
- ReDuCTO (NCT01567397)
- Where
- 4 sites in Germany
- Volunteers
- 87 people
- Sponsor
- Technische Universität Dresden
Dupuytren Contracture, Dupuytren's Disease
Effectiveness of Night Splinting After Percutaneous Needle Fasciotomy in Dupuytren's Contracture
Dupuytren's contracture (DC) is associated with progressive finger flexion and extension deficit caused by fibrosis in the palm and digits.
- Trial name
- NCT05300893
- Testing
- No night splint
- Where
- 3 sites in Sweden
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Dupuytren's Contracture
Post Approval Commitment Study
An agreement has been made to conduct a post-approval commitment study that provides supplementary information relating to the use of Xiapex® as well as other non-pharmacological treatments for Dupuytren's contracture by health…
- Trial name
- NCT01444729
- Testing
- Xiapex, surgery
- Where
- 7 sites in Norway, Spain
- Volunteers
- 305 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren Contracture
Comparing the Effectiveness of Two Post-fasciectomy Rehabilitation Protocols in Patients With Dupuytren's Disease
Dupuytren's disease can cause physical impairments that lead to reduced functional performance in personal care, work-related and leisure activities. The prevalence of Dupuytren's disease increases with age.
- Trial name
- NCT03982719
- Testing
- Brief protocol, Intense protocol
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Véronique Flamand
Dupuytren's Disease
Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's
This is a prospective, multi-centre, pragmatic randomized controlled trial to compare both the clinical effectiveness and cost-effectiveness of collagenase injections (CI) versus limited palmar fasciectomy (LPF) to determine if…
- Trial name
- EXTEND (NCT02725528)
- Testing
- collagenase injection, limited palmar fasciectomy
- Where
- 10 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dupuytren Contracture
Trial Comparing Treatment Strategies in Dupuytren's Contracture
Trial is a prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial. The research objective is to determine, which treatment strategy 1) primary percutaneous needle fasciotomy…
- Trial name
- DETECT (NCT03192020)
- Testing
- Percutaneous needle fasciotomy (PNF), Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], Limited fasciectomy (LF)
- Where
- 6 sites in Finland
- Volunteers
- 302 people
- Sponsor
- Tampere University
Dupuytren's Contracture
Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Background: Dupuytren's contracture is a common hand problem that causes certain fingers to bend towards the palm. Patients with this condition cannot perform daily activities and many are unable to work.
- Trial name
- NCT00565019
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dupuytren Contracture
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily activities. Treatment traditionally involves cutting out diseased tissue, however this can cause damage to important structures in the…
- Trial name
- NCT01776892
- Testing
- Collegenase injection, Needle aponeurotomy
- Where
- Canada
- Sponsor
- University of Alberta
Dupuytren's Contracture of the Hand (Viking's Disease)
Liposome Bupivacaine for WRIST Blocks
Treatment of Dupuytren's contracture requires multiple injections into the palm of the hand to weaken the cords, followed by rupture of the strands 2 days later. Anesthesia is required for both phases of treatment.
- Trial name
- NCT03106519
- Testing
- Liposome bupivacaine + bupivacaine
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Catherine Vandepitte, M.D.
Dupuytren's Contracture
Health-Related Quality of Life in Patients With Dupuytren's Disease
Main Research Questions: We want to measure the change in quality of life in Dupuytren's disease patients who do and do not undergo surgery.
- Trial name
- NCT00468949
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Dupuytren's Disease
Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859
The purpose of study AUX-CC-860 is to assess the durability of response of the AA4500 treatment regimen. This study will also evaluate long-term safety and progression of disease in joints.
- Trial name
- NCT00954746
- Where
- 39 sites in United States, Australia and 4 more
- Volunteers
- 645 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company