Clinical trials: Durability
Durability of Implanted Intravascular Stents, Hemodynamic Effect of Implanted Intravascular Stents
Intravascular Stents Fracture Effects
The goal of the study is to evaluate long term durability and hemodynamic effect of implanted stents in the aortic arch and in pulmonary artery branches.
- Trial name
- NCT01382381
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Crohn's Disease
Study to Assess Speed of Onset and Durability of Effectiveness of Upadacitinib in Adult Participants With Moderate to Severe Crohn's Disease (CD) in Real World Clinical Practice.
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective upadacitinib is in treating moderately to severely active CD in real world.
- Trial name
- UPlift (NCT05930275)
- Where
- 180 sites in Australia, Bulgaria and 15 more
- Volunteers
- 1,200 people
- Sponsor
- AbbVie
Hepatitis C
Durability of Virologic Response and/or Viral Resistance Patterns in Participants With Chronic Hepatitis C Who Have Been Previously Treated With Grazoprevir (MK-5172) (MK-5172-017)
This is a three-year (except for participants with chronic kidney disease [CKD] or cirrhosis) multicenter study to follow participants who received at least one dose of grazoprevir (MK-5172) in a previous study to determine…
- Trial name
- NCT01667081
- Testing
- Grazoprevir
- Volunteers
- 2,438 people
- Sponsor
- Merck Sharp & Dohme LLC
Slow Transit Constipation
Efficacy and Safety of Fecal Microbiota Transplantation for Slow Transit Constipation
The purpose of this study is to evaluate the effect of fecal microbiota transplantation in adults with slow transit constipation.
- Trial name
- NCT02526849
- Testing
- Fecal microbiota transplantation (FMT), Conventional treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Prosthesis Durability
Vallecular Bolus Aggregation During Swallowing for Implant Overdenture.
evaluate the effect of implant retained mandibular overdenture on vallecular bolus aggregation during chewing and subsequent swallowing of solid food consistency.
- Trial name
- NCT06958055
- Testing
- videofluroscopy evaluation of swallowing function
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Eosinophilic Asthma, Severe Asthma
Fasenra: An Asthma Study
The goal of this observational study is to learn more about the effectiveness of benralizumab (Fasenra, 30 mg every 8 weeks) in maintaining asthma control in people with severe eosinophilic asthma.
- Conditions
- Eosinophilic Asthma, Severe Asthma, Severe Eosinophilic Asthma, Asthma
- Trial name
- NCT07654842
- Testing
- Budesonide-albuterol, Benralizumab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Endeavor Health
Prurigo Nodularis
A Study to Evaluate the Durability of Response and Safety of Nemolizumab for 24 Weeks in Participants With Prurigo Nodularis
The main objective of this study is to assess the long-term durability of response over a 24-week period following withdrawal of nemolizumab in participants with prurigo nodularis (PN) who previously responded to treatment in the…
- Trial name
- NCT05052983
- Testing
- Nemolizumab
- Where
- 14 sites in United States, Austria and 5 more
- Volunteers
- 34 people
- Sponsor
- Galderma R&D
Malaria,Falciparum
Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)
This study will assess the durability of protection of a single immunisation with the Genetically Attenuated Parasite 2 (GA2) against controlled human malaria infection by rechallenging previously immunised and protected…
- Trial name
- NCT06293339
- Testing
- CHMI with 3D7 malaria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hepatitis B
B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants
This multi-country, longitudinal follow-up study will enrol adults with chronic hepatitis B (CHB) who previously participated in the Phase III B-Well-1 ((202009: NCT05630807) or B-Well-2 (219288: NCT05630820) studies, received 24…
- Trial name
- B-Ensure (NCT07908459)
- Testing
- Bepirovirsen
- Volunteers
- 303 people
- Sponsor
- GlaxoSmithKline
Ileostomy - Stoma
Safety, Performance and Durability of the TIES® Implant in Patients Requiring a Permanent Ileostomy
Study to assess the safety, performance and durability of the TIES® transcutaneous titanium implant in patients requiring a permanent ileostomy.
- Trial name
- NCT03416023
- Testing
- TIES® (Transcutaneous Implant Evacuation System)
- Where
- 4 sites in Sweden, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Ostomycure AB
HIV, Infant Exposure to Efavirenz
Option B+: Study on Safety, Viral Suppression, and Survival on Second Line ART
To characterize safety, durability, antiretroviral treatment (ART) resistance, and clinical outcomes for mothers and infants exposed to the efavirenz-based Option B+ regimen for Prevention of Mother to Child Transmission (PMTCT)…
- Trial name
- S4 (NCT02249962)
- Where
- Malawi
- Volunteers
- 12,011 people
- Sponsor
- University of North Carolina, Chapel Hill
Ebola Vaccine
Immunity Induced by VSV-EBOV and Assessment of a Booster Dose in Individuals at Potential Occupational Risk for Exposure
This study is a multi-center, open label, randomized phase 3b trial to assess the durability of Immunity induced by the Ebolavirus Vaccine VSV-EBOV ( with or without booster vaccination) in individuals at potential occupational…
- Trial name
- PREPARE (NCT05959421)
- Testing
- ERVEBO® (rVSV∆G-ZEBOV-GP)
- Where
- 2 sites in Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hepatitis C
3-Year Observational Virology Follow-up Study in Subjects Who Participated in Studies of Idenix Anti-HCV, Direct Acting Antivirals
All subjects in this study have previously been in an Idenix HCV study and received study drug for 3 consecutive days. Subjects who had received placebo in a previous Idenix study will not be enrolled in this study.
- Trial name
- NCT01721265
- Volunteers
- 145 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Low Back Pain
Durability of Yoga for Veterans With Low Back Pain
Chronic low back pain is a prevalent condition among VA patients, but many current treatment options have side effects or limited effectiveness.
- Trial name
- NCT07053787
- Testing
- Standard Yoga, Enhanced Yoga
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Transgenderism, Erectile Dysfunction
Epithesis Versus Prosthesis in Post-phalloplasty Transgender Patients.
Transgender and gender diverse (TGD) individuals most often choose for phalloplasty as a means to create masculine external genitalia.
- Conditions
- Transgenderism, Erectile Dysfunction, Prosthesis Durability, Gender Dysphoria
- Trial name
- EROS (NCT05883553)
- Testing
- Usability and added value of device within sexual activity
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Erectile Dysfunction, Botulinum Toxin
Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction
purpose: The aim of this study is to compare the safety, efficacy and durability of different doses of BTX-A (50 and 100 unit) in the treatment of Vasculogenic Erectile Dysfunction after failure of other ICI therapy.
- Trial name
- NCT03355963
- Testing
- saline injection, Botulinum toxin type A 50 units, Botulinum toxin type A 100 units
- Volunteers
- 200 people
- Sponsor
- Benha University
Chronic Hepatitis B
Prospective Observational Cohort Study for the Durability of Anti-viral Therapy in Patients With Chronic Hepatitis B
The aim of this study is to investigate the off-treatment sustained virological and biochemical response in chronic hepatitis B patients following the guideline by the Asian Pacific Association for the Study of the Liver (APASL)…
- Trial name
- NCT01533051
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Fabry Disease, Lysosomal Storage Diseases
A Long Term Follow-Up Study of Fabry Disease Subjects Treated With FLT190
Fabry disease is a rare, X-linked inborn error of glycosphingolipid metabolism caused by an abnormal gene encoding the α-galactosidase A (αGLA) enzyme.
- Trial name
- NCT04455230
- Testing
- FLT190
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Spur Therapeutics
Prosthesis Durability
Management of Severely Atrophied Maxillary Ridge Using Quad Zygomatic Implants
This clinical study will aim to compare and evaluate zygomatic implant stability, occlusal contact, and bone level changes around dental implants
- Trial name
- NCT06031506
- Testing
- Implant supported hybrid maxillary prosthesis
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Tooth Movement
Alignment Efficiency and Coating Durability of Aesthetic Archwires
This study investigates the efficiency of orthodontic aesthetic archwires which are coated with tooth-colored materials and the durability of the coatings after being used.
- Trial name
- RCT (NCT03876184)
- Testing
- Aesthetic archwires, Control group
- Where
- 3 sites in Malaysia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia