Clinical trials: Dydrogesterone
PCOS, ICSI
The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients"
To analyze the effect of pretreatment with dydrogesterone vs combined estradiol valerate and dydrogesterone on embryologic parameters, chemical and clinical pregnancy rates of ICSI in women with PCOS.
- Trial name
- NCT05300841
- Testing
- dydrogesterone 20 mg /d (Duphaston, Abott Healthcare , Egypt), estradiol valerate 2 mg /d (white tablets of cycloprognova, Bayer Shering, Germany)
- Volunteers
- 500 people
- Sponsor
- Sohag University
Postmenopause
Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination
The purpose of this study is to demonstrate endometrial safety of continuous combined 0.5 mg estradiol and 2.5 mg dydrogesterone.
- Trial name
- NCT00160316
- Testing
- 0.5 Mg Estradiol and 2.5 Mg Dydrogesterone
- Where
- 22 sites in Croatia, Poland and 2 more
- Volunteers
- 454 people
- Sponsor
- Solvay Pharmaceuticals
Sterility, Infertility
Oral Versus Vaginal Progesterone in the Luteal Support in Cryo-warmed Embryo Transfer Cycles
In IVF/ICSI cycles, the progesterone levels induced by ovarian stimulation are low, therefore the luteal phase is supported by progesterone.
- Trial name
- NCT03619707
- Testing
- Progesterone
- Where
- Lebanon
- Volunteers
- 157 people
- Sponsor
- American University of Beirut Medical Center
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Endometriosis, Endometriosis Ovary
A Multicenter, Observational Clinical Study of Dydrogesterone
The objective of this study was to investigate the efficacy and safety of dydrogesterone in the long-term management of ovarian endometriosis cyst after surgery.
- Trial name
- NCT05976529
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Guangdong Women and Children Hospital
Luteal Phase Defect
Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support
The purpose of this study is to compare efficacy and tolerability of the dydrogesterone and the vaginal progesterone, used for luteal phase support.
- Trial name
- NCT01178931
- Testing
- Oral dydrogesterone, Crinone 8% gel
- Where
- Croatia
- Volunteers
- 853 people
- Sponsor
- University of Zagreb
Oocyte Donors, Oocyte Donation
Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone
The last decade has shown a progressive scientific interest for new strategies to improve the outcomes of controlled ovarian stimulation (COS).
- Trial name
- LadyDe (NCT05521828)
- Testing
- Follitropin delta (Rekovelle), Duphaston, GnRH agonist (Gonapeptyl)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Recurrent Miscarriage
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).
- Trial name
- NCT00193674
- Testing
- Dydrogesterone
- Where
- 3 sites in Austria, Poland
- Volunteers
- 71 people
- Sponsor
- Abbott Products
Endometriosis
Study of Real Clinical Practice to Evaluate the Effects of Oral Dydrogesterone for Treatment of Confirmed Endometriosis
A non-interventional, observational program to assess the effects of dydrogesterone (Duphaston®) 6-months-administration in patients with confirmed endometriosis in a post-marketing setting in the Russian Federation
- Trial name
- NCT03690765
- Testing
- Duphaston® (Dydrogesterone)
- Where
- 21 sites in Russia
- Volunteers
- 350 people
- Sponsor
- Abbott
IVF
Dydrogesterone, Cetrorelix Acetate and Triptorelin in Intra Cytoplasmic Sperm Injection Outcomes
To compare the effects of Duphaston compared to GnRH agonist and antagonist on the prevention of premature LH surge and quality of retrieved oocytes and embryos in women undergoing intra-cytoplasmic sperm injection.
- Trial name
- NCT05972902
- Testing
- Dydrogesterone, Cetrorelix acetate, Triptorelin
- Where
- Egypt
- Volunteers
- 387 people
- Sponsor
- Beni-Suef University
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Threatened Miscarriage
Non-interventional Study of Therapy for Threatened Miscarriage
Study the efficacy and safety of therapy for threatened miscarriage with medicinal products Utrogestan (micronized progesterone), 200 mg capsules (Besins Healthcare SA, Belgium), and Duphaston (Dydrogesterone), 10 mg coated…
- Trial name
- NCT03309735
- Testing
- Micronized progesterone, Dydrogesterone
- Where
- 17 sites in Russia
- Volunteers
- 1,241 people
- Sponsor
- Besins Healthcare
Subfertility
Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support.
- Trial name
- NCT03859921
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 716 people
- Sponsor
- The University of Hong Kong
Preterm Labor
Different Types of Progesterone in the Prevention of Preterm Labor
Preterm birth is a common problem in obstetric care,with estimates ranging from 5% in several European countries to 18% in some African countries, Preterm labor defined as delivery before 37 completed weeks is the leading cause…
- Trial name
- NCT03537287
- Testing
- 17 alpha hydroxyprogestrone caproate, Vaginal progesterone, Oral dydrogesterone
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Uterine Fibroids Affecting Pregnancy
Composition for Treating Uterine Fibroid (SB-UF)
Pregnenolone \& Pyridoxal Phosphate SB-UF for treating uterine fibroids in women's pregnancies to lose the size of fibroids and to dissolve fibroids.
- Trial name
- SB-UF (NCT04762316)
- Testing
- SB-UF
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Trieu, Nguyen Thi, M.D.
Infertility
Comparison of 3 Different Protocols for Preventing Premature Ovulation in Ovarian Stimulation Cycles
The aim of study is to evaluate the results of three different protocols for prevention of premature ovulation in ovarian stimulation cycles. All patients that undergo IVF cycles are randomly divided into three groups.
- Trial name
- NCT05767086
- Testing
- Gonadotropin releasing hormone antagonist (Cetrotide), Medroxyprogesterone Acetate (Tarlusal), Dydrogesterone
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Menopause
Study to Compare the Effect of Hormone Replacement Therapy (HRT) on Breast and Cardiovascular Metabolic Markers in Postmenopausal Women
This study is to evaluate the effects of continuously combined 17b-estradiol/dydrogesterone in comparison with tibolone on the breast metabolic markers, in particular the total insulin-like growth factor-1 (IGF-1), in…
- Trial name
- NCT00145522
- Testing
- 17ß-Estradiol/Dydrogesterone, Tibolone
- Where
- 11 sites in Italy
- Volunteers
- 135 people
- Sponsor
- Solvay Pharmaceuticals
Infertility
Progesterone Versus Progesterone Plus Dydrogesterone in FET
Frozen embryo transfer (FET) has been increasing important in IVF. Progesterone is essential for the endometrial secretory transformation, establishment and maintenance of pregnancy.
- Trial name
- MiDRONE (NCT03998761)
- Testing
- Micronized Progesterone, Micronized progesterone plus dydrogesterone
- Where
- Vietnam
- Volunteers
- 1,364 people
- Sponsor
- Mỹ Đức Hospital
Fibroids
Fibroids in Women of Reproductive Age and Women Pregnancy
Dydrogesterone Multivitamin Nature treatment of fibroids in women of reproductive age and women pregnancy to lost the size fibroids.
- Trial name
- Fibroids (NCT02620345)
- Testing
- Dydrogesterone M ( case 1 ), Dydrogesterone M ( case 2 )
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Trieu, Nguyen Thi, M.D.
Observational Study, Dydrogesterone
Observational Study of Dydrogesterone in Cycle Regularization
Dydrogesterone has been widely used worldwide for various gynecological and obstetric indications: Dydrogesterone is effective in cycle regulation treatment.
- Conditions
- Observational Study, Dydrogesterone, Irregular Menstrual Cycle, Abnormal Uterine Bleeding
- Trial name
- NCT02029144
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Fudan University