Clinical trials: Dysphagia, Esophageal
Achalasia
Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders
The purpose of this study is to show that the Per-Oral Endoscopic Myotomy (POEM) procedure is an effective treatment for people with achalasia.
- Trial name
- POEM (NCT02482337)
- Testing
- POEM
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Achalasia
Institutional Outcome Data From Per-oral Plication of the Esophagus
Researchers are reviewing and analyzing surgical and clinical outcomes of subjects who underwent POPE for end-stage achalasia, a sigmoid esophagus, or a redundant conduit that has been used to replace the esophagus.
- Trial name
- NCT03875365
- Testing
- POPE
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Gastroesophageal Reflux, Esophageal Motility Disorders
High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux
This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative…
- Conditions
- Gastroesophageal Reflux, Esophageal Motility Disorders, Upper Gastrointestinal Disorder
- Trial name
- NCT05132816
- Testing
- high-resolution manometry
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Gastroesophageal Reflux Disease
Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn
Esophageal hypersensitivity/Functional heartburn are common among non-erosive reflux disease (NERD) patients who do not response to proton pump inhibitors.
- Trial name
- NCT01753128
- Testing
- imipramine
- Where
- Thailand
- Volunteers
- 83 people
- Sponsor
- Mahidol University
Laryngopharyngeal Reflux
Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment
This study proposes to investigate prospectively, the presence of molecular markers for inflammation in laryngopharyngeal reflux (LPR) patients and to study the effect of a proton pump inhibitor (Aciphex) on these molecular…
- Trial name
- NCT00204698
- Testing
- Aciphex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Utah
Oculopharyngeal Muscular Dystrophy
Screening in Oculopharyngeal Muscular Dystrophy
Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria.
- Trial name
- NCT02877784
- Testing
- Videofluoroscopic swallowing study, Functional Oral Intake Scale, Eating Assessment Tool-10
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Dysphagia
Effects of IOPI on Swallowing Function and Functional Status in Geriatric Patients
This project is an exploratory study that aims to investigate the effects of IOPI therapy on the swallowing function and tongue strength of geriatric patients in a geriatric ward in an acute hospital.
- Trial name
- NCT05074784
- Testing
- IOPI Therapy, Tongue Depressor Traditional Intervention
- Volunteers
- 84 people
- Sponsor
- Khoo Teck Puat Hospital
GERD, Cough
Ablation of Esophageal Inlet Patches in Patients Referred for Bravo pH-Testing
Patients with suspected extra-esophageal manifestations of gastro-esophageal reflux disease (GERD), such as cough, hoarseness, and globus, are often referred for pH testing.
- Conditions
- GERD, Cough, Metaplasia
- Trial name
- NCT05131932
- Testing
- Endoscopic ablation of inlet patch
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Gastroesophageal Reflux
Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to determine the effect of vonoprazan compared to esomeprazole for preventing heartburn symptoms over a 4-week treatment period in participants who have a partial response to treatment with…
- Trial name
- NCT02743949
- Testing
- Vonoprazan, Esomeprazole
- Where
- 39 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 256 people
- Sponsor
- Takeda
Barrett Esophagus, Gastroesophageal Reflux
Demographics and Findings of Upper Endoscopy Patients
The purpose of this study is to evaluate the demographics, patients symptoms, and findings during endoscopy. Patients presenting for an endoscopy procedure to the KCVA GI endoscopy suite, will be asked to fill out questionnaires…
- Trial name
- NCT00576992
- Where
- United States
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Head and Neck Cancer, Dysphagia
QUantitative Assessment of Swallowing After Radiation (QUASAR)
To use novel methods for quantitative analysis of VFSS (videofluoroscopic swallow study, also known as modified barium swallow) to study and compare dysphagia in patients treated for head and neck carcinoma with concurrent…
- Conditions
- Head and Neck Cancer, Dysphagia, Oropharyngeal Dysphagia, Oropharynx Cancer
- Trial name
- QUASAR (NCT04359199)
- Testing
- Radiation Therapy, Cetuximab, Chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Loren Mell, MD
Esophageal Achalasia
To Assess the Feasibility of Same Day Discharge Following a POEM Procedure
This is a study of an investigational surgical procedure for the treatment of achalasia the inability of smooth muscle to move food down the esophagus.
- Trial name
- POEM2 (NCT02572193)
- Testing
- POEM
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Gastroesophageal Reflux Disease, Obesity
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
The investigators long-term goal is to understand how PPIs influence energy balance in both obese and normal-weight individuals.
- Trial name
- NCT02457104
- Testing
- Colonoscopy, Weight and diet questionnaire
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gastroesophageal Reflux
Efficacy and Safety of Thread Embedding Acupuncture in Treating Gastroesophageal Reflux Disease
Gastroesophageal reflux disease is a very common disease nowadays. Proton-pump inhibitors (PPIs) are the first-line treatment for this disease. However, the effectiveness of treatment with PPIs is still limited.
- Trial name
- NCT05353933
- Testing
- Thread embedding acupuncture, Pantoprazole 40mg
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Head and Neck Cancer, Stroke
Real-Time Internet Evaluation of Swallowing
The purpose of this study is to determine whether real-time internet evaluations of swallowing, or x-ray swallow studies viewed over closed internet circuit, are a reliable method of evaluating swallowing function.
- Trial name
- NCT00580138
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Aspiration, Laryngeal Cancer
NewBreez for Airway Protection in Head and Neck Cancer Patients With Chronic Aspiration
Laryngeal dysfunction is a problem that affects many patients after laryngeal cancer therapy (surgery or radio/chemotherapy). Laryngeal dysfunction is associated with higher incidences of aspiration and respiratory tract…
- Trial name
- NCT02437513
- Testing
- NewBreez
- Volunteers
- 2 people
- Sponsor
- ProTiP Medical
Gastroesophageal Reflux Disease
Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of On-demand Therapy Versus Maintenance Therapy
Maintenance treatment with proton pump inhibitor (PPI) is the most widely recommended modality of treatment for long-term management of gastroesophageal reflux disease (GERD).
- Trial name
- NCT00164840
- Testing
- Esomeprazole
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Chinese University of Hong Kong
Dysphagia, Oropharyngeal, Cerebral Palsy
Effect of Kinesio Tape on Oral and Pharangeal Swallowing Phases in Children With Spastic Cerebral Palsy
The purpose of current study is to investigate the effect of kinesio tape in children with spastic cerebral palsy having oropharyngeal dysphagia
- Trial name
- NCT06157489
- Testing
- Kinesio tape
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Cairo University
Laryngitis, Reflux
Inter-rater Reliability of the Reflux Finding Score Among Gastroenterologists
Title: Inter-rater reliability of the reflux finding score based on endoscopic laryngeal findings in the diagnosis of laryngopharyngeal reflux disease Participants: Voluntary participants after invitation among members (a total…
- Trial name
- NCT02048449
- Volunteers
- 21 people
- Sponsor
- Chuncheon Sacred Heart Hospital
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