Clinical trials: Dysphoria
Gender Dysphoria, Adult
Comparative Study of Gender Identity Disorder Versus Control
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
- Trial name
- TRANSIDENT (NCT04935164)
- Testing
- Psychiatric evaluations
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Henri Laborit
Dysphoria
Neural Responses and Dysphoria: Modulation by a Pharmacological Probe
This study aims to improve understanding of how people with low mood and negative feelings (known as dysphoric) may be different from people with normal mood and feelings (nondysphoric) when responding to a variety of social and…
- Trial name
- NCT01101685
- Testing
- Escitalopram
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV/AIDS, STI
Transgender Cohort Study of Gender Affirmation and HIV-related Health
This observational research study will evaluate medical gender affirmation delivered in primary care as an intervention to reduce disparities in HIV-related outcomes (e.g., low rates of PrEP uptake for HIV-uninfected patients…
- Conditions
- HIV/AIDS, STI, Gender Dysphoria, Transsexualism
- Trial name
- NCT03595956
- Testing
- Medical gender affirmation
- Where
- United States
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Gender Dysphoria
Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content
Background: Sex hormones are believed to play an important role in the development and progression of cardiovascular disease. However, the gender gap in onset and mortality is not yet completely understood.
- Trial name
- NCT06245681
- Testing
- gender affirming hormone therapy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gender Identity Disorder
Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain function and structure induced by long-term opposite-sex steroid hormone administration in transsexual subjects. Our aim is 1.
- Trial name
- NCT01292785
- Testing
- Hormones
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Transgenderism, Gender Dysphoria
Effectiveness of Speech Therapy in Trans Women.
One of the greatest hurdles in the transition of transgender persons is that voice, speech and communication are not congruent with the desired gender.
- Conditions
- Transgenderism, Gender Dysphoria, Speech Therapy, Voice Disorder Due to Transsexualism
- Trial name
- NCT04708600
- Testing
- Pitch Elevation Therapy, Articulation Resonance Therapy
- Where
- Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gender Incongruence, Cardiovascular Disease (CVD) Risk Factors
Cardiomodulatory Effects of Gender-Affirming Hormone Therapy
Gender-affirming hormone therapy is today a well-established treatment for individuals experiencing gender-incongruence. However, little is known about the long-term effects of gender-affirming hormone therapy on the…
- Trial name
- CARMEN (NCT07128771)
- Where
- Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Gender Dysphoria
Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria
The current project aims to improve the well-being of trans and nonbinary (TNB) individuals through an online intervention (Trans Care) targeting the reduction of symptoms of gender dysphoria.
- Trial name
- NCT05903911
- Testing
- Trans Care Web App
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gender Dysphoria
Acoustic and Perceptual Effects of Intonation Training in Gender Diverse People
The aim of this project is to investigate the short- and the longer-term effect of intonation training on vocal characteristics, listener perceptions and patient related outcome measures (PROMS) in gender diverse people using a…
- Trial name
- B6702021001262 (NCT05204732)
- Testing
- Intonation training
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Ghent
Dysphoric Mood
Components of Placebo Effects in Sadness
Research has shown that placebo effects contribute substantially to clinical outcomes. Recent evidence suggests that placebos remain effective even if they are openly described as placebos (so-called Open-Label Placebos).
- Trial name
- COPES (NCT03507959)
- Testing
- OLP scientifically-objective, OLP personally-affective, DP scientifically-objective
- Where
- Germany
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Transgender, Gender Incongruence
China Gender-affirming Hormone Therapy Study
Data about transgender medical care, especially the gender-affirming hormone therapy (GAHT) is extremely insufficient in China. Few evidence exists in the physical and psychological effects of the hormonal treatment in Chinese…
- Trial name
- CGAHT (NCT05318755)
- Testing
- GAHT for transgender men, GAHT for transgender women
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Stigma, Social, Gays
An LGBT-Competency Program for Mental Health Professionals in Romania
Lesbian, gay, bisexual and transgender individuals (LGBTI) present increased morbidity compared to the general population, which is attributed to healthcare discrimination and lack of LGBT-specific expertise, especially in…
- Conditions
- Stigma, Social, Gays, Lesbians, Bisexuals
- Trial name
- NCT03602222
- Testing
- Mobile web training LGBT mental health, In-person training LGBT mental health
- Where
- Romania
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Gender Dysphoria
Effects of Gender-affirming Hormone Therapy on Transgender People
This prospective cohort study aims to assess the impact of gender-affirming hormone therapy (GAHT) on transgender individuals' physical, psychological, social, and quality of life aspects.
- Trial name
- NCT06022562
- Where
- Taiwan
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Gender Dysphoria, Voice Disorder Due to Transsexualism
Investigation of the Perceptual and Acoustic Voice in Trans Man
The aim of the study is to follow acoustic and perceptual voice changes in trans men during hormone therapy and to examine the relationship between psychosocial and vocal characteristics and testosterone measured in routine…
- Conditions
- Gender Dysphoria, Voice Disorder Due to Transsexualism, Transgender Persons, Hormone Replacement Therapy
- Trial name
- NCT05166083
- Testing
- Testosterone Hormon Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Surgery, Larynx
Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty
The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized…
- Conditions
- Surgery, Larynx, Transgenderism, Gender Dysphoria
- Trial name
- NCT06439290
- Testing
- Phonosurgery, Mastectomy/breast augmentation
- Where
- 2 sites in Belgium
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gender Dysphoria
Brain Health in Transgender Adults
The purpose of this study is to test whether and how a person's brain changes in the first few months after starting gender affirming hormone therapy (GAHT).
- Trial name
- NCT07624747
- Testing
- Magnetic Resonance Imaging, Cognition and Health Tests, Optional Exercise Test
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gender Dysphoria, Adolescent
Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process…
- Trial name
- TESE (NCT06400199)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Hypogonadism, Gender Identity Dysphoria
The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population
It has been known that both estrogen and testosterone are the major sex steroids regulating bone metabolism and other physiological changes in both male and female, respectively.
- Trial name
- NCT06247267
- Testing
- Fortesta, Estradiol
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Transgender Health, Gender Dysphoria
Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women
Transgender women living with Human Immunodeficiency Virus (HIV) may prioritize gender-affirming hormonal therapy over antiretroviral drug therapy.
- Conditions
- Transgender Health, Gender Dysphoria, Transgender Women, Human Immunodeficiency Virus
- Trial name
- IDENTIFY (NCT04283656)
- Testing
- Doravirine/Lamivudine/Tenofovir, Spironolactone 100mg, Estradiol 2mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Gender Dysphoria, Mastectomy
Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy
The goal of this randomized, prospective, interventional clinical trial is to evaluate the use of Brijjit® in reducing the incidence of hypertrophic scarring in individuals undergoing gender-affirming bilateral double incision…
- Conditions
- Gender Dysphoria, Mastectomy, Hypertrophic Scar
- Trial name
- FMTB Brij (NCT07147166)
- Testing
- Brijjit® BP100-6 and BP-75, Control: Standard of care and normal wound dressing
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco