Clinical trials: Dyspnea, Paroxysmal
Cognitive Dysfunction
Postoperative Cognitive Dysfunction as Geriatric Syndrome
This study is testing cognitive function before and after the surgery, with patient's informed consent. Patients of interest are 65 year or older, undergoing surgery in general or regional anesthesia.
- Trial name
- NCT05648890
- Where
- Czechia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Cough
Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher
This study is for therapeutic confirmation of AG1321001 to evaluate the safety and efficacy as an anti-tussive agent in cough patients.
- Trial name
- NCT00380315
- Testing
- AG1321001(drug)
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Monogenic Diseases, Genetic Diseases, Inborn
Health Economic Evaluation of Non-Invasive Prenatal Exclusion Diagnosis
Since the discovery of a small fraction of circulating cell-free fetal DNA (ccffDNA) in the blood of the mother, non-invasive prenatal diagnosis (NIPD) techniques using a simple blood sample have been developed to 1) screen for…
- Trial name
- PRENATSAFE (NCT07469657)
- Testing
- NIPD by NGS
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Perioperative Neurocognitive Disorders
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling
The term perioperative neurocognitive disorders (PND) is derived from postoperative cognitive dysfunction (POCD), and has been renamed as PND in recent years in accordance with the latest international consensus.
- Trial name
- NCT07652008
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cubital Tunnel Syndrome, Peroneal Nerve Entrapment
Mechanomyography for Predictor of Prognosis in CuTS and PND Patients
The study will be a non-blinded two cohort design consisting only of symptomatic patients with CuTS or compressive peroneal neuropathy or in need of peroneal nerve decompression. The first cohort will be - patients with CuTS.
- Trial name
- NCT04322448
- Testing
- Mechanomyography (MMG)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Heart Failure, Congestive, Heart Decompensation
A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels
The purpose of this safety study is to evaluate NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure), in subjects with worsening congestive heart failure…
- Trial name
- NCT00271557
- Testing
- nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Heart Failure
Heart Failure and a Preserved Ejection Fraction
This will be a cross sectional study comparing patients with HFpEF and age-matched, non-HF controls recruited from the community.
- Trial name
- NCT00586833
- Testing
- O2 consumption max bike test
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Postnatal Depression
Three Model Care Pathways for Postnatal Depression
The study evaluates three best-practice care pathways for postnatal depression (PND) by comparing sole General Practitioner (GP) management to GP management in combination with CBT-based counselling from either a Psychologist or…
- Trial name
- NCT01002027
- Testing
- CBT-Counselling
- Where
- Australia
- Volunteers
- 68 people
- Sponsor
- University of Melbourne
Dyspnea, Paroxysmal
Circuit Training With and Without Upper and Lower Limb Resistance Training in Post-CABG Patients
This study aims to evaluate the contrasting effects of circuit training with and without upper and lower limb resistance training on paroxysmal nocturnal dyspnea, functional capacity and endurance on post-CABG patients.
- Trial name
- NCT07484568
- Testing
- Circuit Training with upper and lower limb Resistance Training, Circuit Training Exercises
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Perinatal Depression
Virtual Psychiatric Care for Perinatal Depression
Perinatal depression occurs in 15% of pregnant women and new mothers, yet as few as 1 in 5 receive adequate treatment. It has a negative impact on the woman herself, as well as a potential for serious consequences for her child.
- Trial name
- Virtual-PND (NCT03291600)
- Testing
- Virtual Psychiatric Care
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- Women's College Hospital
Pilonidal Disease
Comparison Between Two Different Technique in Treatment of Chronic Pilonidal Disease
Comparison between limberg flap and Karydakis flap for treatment of pilonidal disease.
- Trial name
- PND (NCT01268969)
- Testing
- KARYDAKIS GROUP, Lamberg flap technique
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Hepatic Encephalopathy
Mechanisms of Perioperative Systemic Inflammation in the Development of PND in Cirrhotic Patients
Chronic Liver Disease (CLD) is associated with significant cognitive dysfunction, including hepatic encephalopathy (HE), which is driven by systemic inflammation and blood-brain barrier (BBB) disruption.
- Trial name
- NCT07082946
- Volunteers
- 148 people
- Sponsor
- Sichuan Provincial People's Hospital
Elderly, Anesthesia
Effect of Intraoperative Sedation on PND in Elderly Patients
The aim of this study was to identify the effects of different depths of sedation and choices of sedative drugs on perioperative neurocognitive disorders in the elderly patients receiving hip surgery under spinal anesthesia.
- Trial name
- NCT04891458
- Testing
- Patients received lighter sedation with propofol after spinal anesthesia., Patients received heavier sedation with propofol after spinal anesthesia, Patients received lighter sedation with dexmedetomidine after spinal anesthesia
- Volunteers
- 160 people
- Sponsor
- Hebei Medical University Third Hospital
Dermatology Disease
Assessment of the 1-year Relapse Rate in Patients with Pemphigus Treated According to the Revised Pemphigus PNDS
In May 2018, the PNDS (national diagnosis and care protocol) for pemphigus drawn up by the autoimmune bullous diseases reference centre was amended to take into account the results of recent studies and proposed, in line with the…
- Trial name
- Etude PRERI (NCT06903494)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Dyspnea, Paroxysmal, Heart Failure, Left Sided
Management of Cardiogenic Pulmonary Edema (RENAU-OAP)
The prevalence of heart failure is estimated to 2.3 percent of the adult population and strongly increases with age, according to french disability-health surveys.
- Trial name
- RENAU-OAP (NCT03148847)
- Testing
- Baseline care, Referential's dissemination
- Where
- France
- Volunteers
- 859 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Cancer, Dyspnea, Paroxysmal
Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients
"Episodic breathlessness (or dyspnea) is one form of chronic refractory breathlessness characterized by a severe worsening of breathlessness intensity or unpleasantness beyond usual fluctuations in the patient's perception.
- Trial name
- EFFENDYS (NCT04635852)
- Testing
- Fentanyl, Immediate release morphine
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
Breast Cancer, Nipple Discharge
A Study on Combined Low-pass Whole-genome and Methylome Testing of Bloody Nipple Discharge Specimens for Benign-Malignant Differentiation.
This is a prospective, single-center diagnostic study testing whether a new, minimally invasive analysis of nipple fluid can distinguish benign from malignant causes of pathologic nipple discharge.
- Trial name
- NCT07250204
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Couples Eligible for Prenatal Exome Sequencing
Parallel Sequencing of Fetal Genome and RNA in the Presence of Ultrasound Warning Signs: a Complementary Approach for the Prenatal Diagnosis of Rare Diseases.
Prenatal exome sequencing (ES) is increasingly used for fetuses with ultrasound-detected anomalies but yields 10-15% variants of uncertain significance (VUS), limiting diagnostic performance, particularly in prenatal settings…
- Trial name
- PrenOmics (NCT07790536)
- Testing
- Genome Sequencing (GS) + RNA-Sequencing (RNA-Seq)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Paraneoplastic Neurologic Degenerations (PNDs)
Studies of Neurological Paraneoplastic Syndromes
This study is for patients with cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome.
- Trial name
- NCT00587106
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent
Assert-IQ Implantable Cardiac Monitor (ICM) Post Market Study
This is a prospective, non-randomized, multi-center, real-world post-market study to collect and evaluate data regarding the performance of the enhanced atrial fibrillation detection algorithm of the Assert-IQTM Implantable…
- Conditions
- Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent, Cardiac Arrhythmia, Ablation
- Trial name
- Assert-IQ (NCT06172699)
- Testing
- Holter monitoring in patients who have been successfully implanted with an Abbott Assert-IQ ICM device
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- Abbott Medical Devices