Clinical trials: Dyspnoea
Chronic Obstructive Pulmonary Disease (COPD)
Safety and Efficacy of Indacaterol Once Daily Versus Salmeterol Twice Daily in Chronic Obstructive Pulmonary Disease (COPD)
This study compared the safety and efficacy of indacaterol 150 µg taken once daily (o.d.) versus salmeterol 50 µg taken twice daily (b.i.d) in patients 40 years old or older with chronic obstructive pulmonary disease.
- Trial name
- INSIST (NCT00821093)
- Testing
- Indacaterol 150 µg, Salmeterol 50 µg
- Where
- 144 sites in United States, Czechia and 6 more
- Volunteers
- 1,123 people
- Sponsor
- Novartis Pharmaceuticals
Dyspnea During Mechanical Ventilation
Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients
The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.
- Trial name
- NCT07205952
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas José de San Martín
Dyspnea, Chronic Obstructive Pulmonary Disease
Menthol for Dyspnea Relief in Health and COPD
Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown.
- Trial name
- MENTHODYSC (NCT05785026)
- Testing
- Menthol inhalation, Strawberry scent, Menthol inhalation and facial airflow
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Dyspnea, Congestive Heart Failure
Comparison Between Lung Ultrasound and Chest Radiography for Acute Dyspnea
For patients presenting to the Emergency Department with acute dyspnea, emergency physicians will be asked to categorize the diagnosis as acute decompensated heart failure or non-cardiogenic shortness of breath a) after the…
- Trial name
- NCT02105207
- Testing
- Lung Ultrasound, Chest Radiography
- Where
- 2 sites in Italy
- Volunteers
- 530 people
- Sponsor
- University of Turin, Italy
SARS-CoV2 Infection, Covid19
S-Nitrosylation Therapy of COVID-19
The primary objective of this study is to provide expanded access of S-nitrosylation therapy for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
- Trial name
- NCT04528771
- Testing
- SNO, Nitrogen gas
- Where
- United States
- Sponsor
- James Reynolds
Tachycardia, Dyspnea
Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study
Most patients with acute COVID-19 (Coronavirus 19) recover within weeks, however a significant number of individuals will develop the post-acute COVID 19 syndrome (PASC).
- Conditions
- Tachycardia, Dyspnea, COVID-19
- Trial name
- PEACE (NCT05096884)
- Testing
- Metoprolol Succinate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hackensack Meridian Health
Spontaneous Breathing Trial in ICU
Benefits of Immersive Virtual Reality on Dyspnoea During a Weaning Test in the Intensive Care Unit.
A weaning trial is a test that simulates physiological respiratory conditions after extubation in order to assess the patient's ability to breathe without the assistance of a ventilator.
- Trial name
- RVI-ERS (NCT06434116)
- Testing
- Immersive virtual reality
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dyspnea
Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED
For the patient with acute dyspnea in the ED, early differentiation between CHF and non-CHF causes is essential for proper management.
- Trial name
- NCT01206621
- Where
- 8 sites in United States, Israel
- Volunteers
- 530 people
- Sponsor
- Deep Breeze
ARDS
Retrospective Postoperative ARDS Study at Vanderbilt University
By examining the intraoperative anesthetic characteristics of patients who developed ARDS postoperatively, we hope to identify variables which have a positive or negative association on the development of ARDS.
- Trial name
- NCT00656071
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Vanderbilt University
Pulmonary Embolism, Quality of Life and Dyspnea
Impact on Quality of Life With Pulmonary RehAbilitation After Pulmonary eMBOlism: RAMBO Study
Pulmonary Embolism (PE) is a common and serious disease. Indeed, the annual incidence is 1/1000 patients per year and the 3-month mortality is 10%, which is twice that of myocardial infarction.
- Trial name
- RAMBO (NCT05015153)
- Testing
- Pulmonary rehabilitation (PR)
- Where
- 6 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
COPD, Breathlessness
Reducing Breathlessness With Dronabinol in COPD Patients
This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive…
- Conditions
- COPD, Breathlessness, Cannabis
- Trial name
- BONG (NCT06473701)
- Testing
- Dronabinol 2.5mg Capsule
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Asthma
Effects of Aerobic Training With and Without Sniff Maneuver
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients.
- Trial name
- NCT07064057
- Testing
- Aerobic exercise combined with the sniff maneuver technique, Aerobic exercise
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension
129Xe MRI Cardiopulmonary
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
- Conditions
- Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia
- Trial name
- NCT06038630
- Testing
- Hyperpolarized Xe129, Oxygen Administration
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Asthma Exacerbation
Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids
We assume that the combination of systemic steroids and inhaled steroid in the first hour of treatment in the ER will decrease the admission rate and improve faster the pulmonary function.
- Trial name
- NCT00397267
- Testing
- inhalation of corticosteroids
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Soroka University Medical Center
Respiratory Distress of Newborn
Feasibility of Using the Neovent in Low-Resource Settings
Breathing problems are a leading cause of newborn death/sickness worldwide but most of deaths are in low resources areas. Over 99% of newborn death is in countries with limited healthcare resources like Nigeria and Nepal.
- Trial name
- Neovent (NCT06697951)
- Testing
- bilevel ventilation with the Neovent
- Where
- 2 sites in Nepal, Nigeria
- Volunteers
- 70 people
- Sponsor
- Tina Slusher
Cervical Spinal Cord Injury, Cervical Cord Injuries Spinal
Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer in Patient With Cervical Spinal Cord Injuries
This randomized clinical trial aims to evaluate the effectiveness of combining Low Volume Nose Resistance Breathing Exercises (LVNRBE) with Incentive Spirometry (IS) on respiratory outcomes in patients with cervical spinal cord…
- Trial name
- NCT07645027
- Testing
- Acapella device plus Incentive Spirometry, conventional respiratory physiotherapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Dyspnea, Malignant Neoplasm
Dexamethasone in Controlling Dyspnea in Patients With Cancer
This phase II trial studies how well dexamethasone works in controlling dyspnea in patients with cancer. Dexamethasone may help control dyspnea (shortness of breath) and improve lung function and quality of life in cancer…
- Trial name
- NCT03367156
- Testing
- Dexamethasone, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- M.D. Anderson Cancer Center
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
COPD, Shortness of Breath
Comparison of Jacobson Relaxation Technique and Pranayama Technique in Patients With COPD
Comparison of Jacobson Relaxation Technique and Pranayama Technique in patients with COPD
- Conditions
- COPD, Shortness of Breath, Quality of Life, Cough
- Trial name
- NCT06463288
- Testing
- Jacobsons Breathing Technique, Pranayama Technique
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Shortness of Breath, Asthma in Children
The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome
Our study aiming to look in improvement of Pediatric Respiratory Assessment Measure (PRAM) score as a primary outcome. The secondary outcomes involving the need for second step management, need for admission and possible side…
- Conditions
- Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use, Salbutamol Adverse Reaction
- Trial name
- NCT05667727
- Testing
- nebulized epinephrine, Salbutamol
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Medical Speciality Board
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