Clinical trials: Dyssynchrony
ARDS, Acute Hypoxemic Respiratory Failure
Incidence of Dyssynchronies in Early ARDS
Patients sedated under mechanical ventilation with acute hypoxemic respiratory failure with a PaO2/FiO2 equal or less than 200mmHg (Acute Respiratory Distress Syndrome, ARDS and non-ARDS) will be included in the study early in…
- Trial name
- BEARDS (NCT03447288)
- Where
- 14 sites in Canada, China and 8 more
- Volunteers
- 300 people
- Sponsor
- Unity Health Toronto
Transcatheter Aortic Valve Replacement
Prognostic Factors in NOP-LBBB After TAVI
The goal of this observational study is to find prognostic factors in patients with a new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI).
- Trial name
- ProgNOP-LBBB (NCT05654792)
- Testing
- Transcatheter aortic valve implantation
- Volunteers
- 230 people
- Sponsor
- Central Hospital, Nancy, France
Cardiac Resynchronization Therapy
Acute Evaluation of the Safety of Left Ventricular-left Ventricular (LV-LV) Delays and Its Effects on Mechanical Dyssynchrony
The purpose of this study is to evaluate the effects of various LV-LV delays during multi-site left ventricular (MSLV) pacing on mechanical dyssynchrony in cardiac resynchronization therapy (CRT) patients post-implant.
- Trial name
- NCT01044784
- Where
- Germany
- Volunteers
- 73 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Systolic
Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT)
Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT).
- Trial name
- NARROW-CRT (NCT01577446)
- Testing
- cardiac resynchronization therapy
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Ospedale Santa Maria di Loreto Mare
Bradyarrhythmia
Mechanical and Electrical Dyssynchrony During His-Bundle Pacing Versus His-Bundle Area Right Ventricular Pacing
The aim of this study is to evaluate mechanical and electrical cardiac dyssynchrony in patients with pacemakers and the right ventricular electrode implanted in His Bundle area.
- Trial name
- NCT04697797
- Testing
- Device Programming
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Systolic Heart Failure
Pilot Study Using Echocardiography to Evaluate Patients With Heart Failure and Dyssynchrony Who Have a CRT-D Device
Out of all the patients that receive a CRT-D ( a dual chamber pacemaker with defibrillator ) for cardiac resynchronization therapy there is approximately one-third that do not respond.
- Trial name
- NCT01127334
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Congestive Heart Failure
New Echocardiographic Parameters for Prediction of Response to Cardiac Resynchronization Therapy
Echocardiography parameters for cardiac dyssynchrony had no predictive value in current multicentric prospective studies concerning cardiac resynchronization therapy.
- Trial name
- NEW-CRT (NCT02375399)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Heart Failure
Study of Left Ventricular Dyssynchrony in Heart Failure Patients
Heart failure has become one of the major epidemics of the modern era. Despite optimal standard drug therapy, the prognosis of patients with heart failure remains poor.
- Trial name
- NCT00953953
- Testing
- Phillips ultrasound system
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Albert Einstein Healthcare Network
Cardiomyopathy, Heart Failure
Adaptive CRT Effect on Electrical Dyssynchrony
The purpose of this study is to better understand how adaptive cardiac resynchronization therapy (aCRT) might benefit patients. aCRT works by sometimes giving stimulation to only the left side of the heart, rather than to both…
- Conditions
- Cardiomyopathy, Heart Failure, Left Bundle Branch Block
- Trial name
- aCRT-ELSYNC (NCT02543281)
- Testing
- Adaptive cardiac resynchronization therapy, Conventional Cardiac Resynchronization Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Larisa Tereshchenko
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Left Ventricular Dyssynchrony, Heart Failure
AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT
Previous experience with cardiac resynchronization therapy (CRT) candidates suggests that selection of these patients can be improved.
- Conditions
- Left Ventricular Dyssynchrony, Heart Failure, Cardiomyopathy, Dilated, Cardiac Remodeling, Ventricular
- Trial name
- AMEND-CRT (NCT04225520)
- Testing
- Cardiac resynchronization therapy ON, Cardiac resynchronization therapy OFF
- Where
- 24 sites in Belgium, Brazil and 9 more
- Volunteers
- 500 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Jet Lag Disorder, Jet Lag
A Study on the Effectiveness of a Dietary Supplement FitoAvia for Jet Lag
Purpose of the study: Evaluation of the effects of dietary supplement Fitoavia in people with dyssynchrony Objectives of the study: 1. Assessment of the condition of patients with jet lag of 4 hours or more 2.
- Conditions
- Jet Lag Disorder, Jet Lag, Jet Lag Type Insomnia, Cognition Improvement
- Trial name
- NCT07695870
- Testing
- Fitoavia, Questionnaire and Physical Exam, cognition tests
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MiraxBioPharma
Congestive Heart Failure
An-Art Study: Atrioventricular (AV) Node Ablation in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) is a highly effective treatment option for patients with symptomatic heart failure and electrical intraventricular dyssynchrony, who are unresponsive to medical therapy.
- Trial name
- NCT00260546
- Testing
- AV-node ablation
- Sponsor
- University Hospital, Basel, Switzerland
Congestive Heart Failure, Heart Disease
Efficiency Study of Triple-Site Cardiac Resynchronization in Patients With Heart Failure
The purpose of this study is to assess the efficiency of permanent biventricular pacing using three ventricular leads in terms of reduction in adverse cardiac events rates, improvement in cardiac capacity and patients' functional…
- Trial name
- TRUST CRT (NCT00814840)
- Testing
- Cardiac resynchronization pacemaker (InSync Sentry or Concerto, Medtronic, Minneapolis, MN,USA) with two intracardiac leads, Triple-site cardiac resynchronization
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Silesian Centre for Heart Diseases
Heart Failure, Ventricular Dyssynchrony
Trip HF Study: Triple Resynchronization in Paced Heeart Failure Patients
The purpose of this study is to evaluate the feasibility of permanent biventricular pacing using three ventricular leads, and its efficacy in terms of inter and intra-ventricular resynchronization, in patients with congestive…
- Trial name
- NCT00187265
- Testing
- Cardiac Resynchronization Therapy
- Where
- France
- Sponsor
- Abbott Medical Devices
Ventricular Rhythm From Artificial Pacing
Right Ventricular Apical Versus True Mid-septal Pacing
Background Right ventricular (RV) artificial apical pacing can negatively impact synchrony of left ventricular contraction. The pacing from the septum of the RV can present an advantage in terms of less expressed dyssynchrony and…
- Trial name
- MS-R (NCT02412176)
- Testing
- Pacing site - the implantation in the right ventricular (RV) apex, Pacing site - the implantation in the septum
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Heart Block, Heart Block Complete
Effect of Site of Right Ventricular (RV) Pacing on RV Function, Left Ventricular (LV) Dyssynchrony and Contraction Efficiency
To evaluate RV systolic function and LV mechanical dyssynchrony and function in different lead position in the RV during permanent pacemaker implantation by using speckle tracking echocardiography (STE) and 3D volumetric ejection…
- Conditions
- Heart Block, Heart Block Complete, Systolic Function
- Trial name
- NCT06636851
- Testing
- Pacemaker and defibrillator
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- South Valley University
RV Pacing, Negative Remodeling
Ultra-high-frequency ECG for Prediction of Left Ventricular Remodeling
The main goal of the project is to prove that ultra-high-frequency ECG (UHF-ECG) can be used as a diagnostic tool that allows the prediction of patients susceptible to the negative effect of right ventricular myocardial pacing.
- Conditions
- RV Pacing, Negative Remodeling, Dyssynchrony, UHF-ECG
- Trial name
- NCT04908033
- Testing
- pacemaker implantation
- Where
- Czechia
- Volunteers
- 368 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Heart Failure, Congestive, Cardiac Pacing, Artificial
Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therapy.
Identifying \& optimizing strategies to reduce the burden of heart failure is vital. Despite advances in pharmacotherapy, patients with heart failure are at high risk for death \& hospitalization.
- Conditions
- Heart Failure, Congestive, Cardiac Pacing, Artificial, Defibrillators
- Trial name
- INCREMENTAL (NCT00399594)
- Testing
- A, B
- Where
- 3 sites in Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Heart Failure
Electrical Activation Mapping Guided Tailor Made Approach for Cardiac Resynchronization Therapy
Background Cardiac Resynchronization Therapy (CRT) is proven to improve survival and heart function of patient with certain electrical conduction abnormality and heart failure.
- Trial name
- NCT03356652
- Testing
- Noninvasive electrical dyssynchrony study
- Where
- Hong Kong
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong