Clinical trials: Dystonia, Cervical
Cervical Dystonia, Blepharospasm
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Our hypothesis is that botulinum toxin injections (with onabotulinum toxin, incobotulinum toxin, and abobotulinum toxin) given at 10-week or shorter intervals for the indication of treatment of muscle spasms associated with…
- Conditions
- Cervical Dystonia, Blepharospasm, Limb Dystonia, Hemifacial Spasm
- Trial name
- NCT05103202
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Cervical Dystonia
A Trial of Non-invasive Stimulation in Cervical Dystonia
Cervical dystonia (CD) is a common movement disorder. Despite the optimization of botulinum toxin injection (BoNT-A) parameters including muscle selection and dosing, a significant proportion of patients report low levels of…
- Trial name
- NCT04057911
- Testing
- Active NIBS
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Western University, Canada
Peripheral Nerve Disease, Muscular Injury
Innervation Characteristics and Determination of Nerve Entry Points of the Musculus Semispinalis Capitis
The aim of this study is to determine the innervation characteristics and nerve entry points of the musculus semispinalis capitis.
- Trial name
- NCT06569563
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia, Spasmodic Torticollis
Identification of Optimal Stimulation Site for Cervical Dystonia Symptoms: An Exploratory Study
The overall objective of this application is to therapeutically target the dysfunctional premotor-motor interaction in dystonia-and to provide a focused treatment of specific anatomical networks in order to reduce side effects…
- Trial name
- NCT01859247
- Testing
- rTMS
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico
Cervical Dystonia
CD-PROBE: Cervical Dystonia Patient Registry for the Observation of onabotulinumtoxinA Efficacy
This study is an observational trial which will measure the efficacy of onabotulinumtoxinA in treating Cervical Dystonia.
- Trial name
- NCT00836017
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 1,046 people
- Sponsor
- Allergan
Primary Cervical Dystonia
Transcranial Electrical Stimulation for Cervical Dystonia
There are two phases. Phase I: A single visit which includes a screening, clinical scales, and a MRI scan with simultaneous tES/sham tES in a randomized block design.
- Trial name
- NCT03369613
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cervical Dystonia
Physiotherapy and Botox for Cervical Dystonia: Impact of Sensory Tricks and Brain Imaging Insights
The primary aim of this study is to investigate improvements of dystonia severity in patients with cervical dystonia (CD) with (DYT-trick) and without sensory trick (DYT-no-trick) following 6 weeks of physiotherapy combined with…
- Trial name
- NCT06881147
- Testing
- Multimodal physiotherapy program
- Where
- Italy
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Spasmodic Torticollis
PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia
The safety and efficacy of Mentor Purified Toxin, Botulinum Toxin Type A, Purified Neurotoxin, injected intramuscularly into the neck, is being evaluated as a treatment for painful and non-painful spasmodic torticollis/cervical…
- Trial name
- NCT00549341
- Testing
- Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin, Physiologic saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mentor Worldwide, LLC
Dystonia
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
Stride Dystonia is a randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of VIM0423 in individuals with isolated dystonia.
- Trial name
- NCT07304089
- Testing
- VIM0423
- Where
- 45 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Vima Therapeutics
Cervical Dystonia,Primary
A Multimodal Approach to Cervical Dystonia Treatment With Association of Botulinum Toxin and Motor Learning Techniques
the aim of this study protocol is to describe, using a longitudinal study, a multimodal approach of treatment of cervical dystonia with botulinum toxin (BoNTA) and a new rehabilitation protocol named SPRInt (Sensory-motor…
- Trial name
- SPRInt (NCT03247868)
- Testing
- Botulinum Toxin+SPRInt
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Torticollis, Cervical Dystonia
Effects of Botulinum Toxin in Cervical Dystonia
Botulinum toxin injection in the contracting muscles has proven to be a safe and effective method of relieving pain and lessening dystonic posturing.
- Trial name
- NCT01056861
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Cervical Dystonia
Efficacy and Safety of MEDITOXIN® in Cervical Dystonia
The purpose of this study is to test the hypothesis that the efficacy and safety of Meditoxin® are not inferior to Botox®'s in the treatment of Cervical Dystonia.
- Trial name
- CD Phase III (NCT03905304)
- Testing
- Medytoxin, Botox
- Volunteers
- 152 people
- Sponsor
- Medy-Tox
Cervical Dystonia
Botox for Cervical Dystonia Following EMG Mapping
The purpose of this study is to determine how to improve treatment of patients with cervical dystonia who have not been helped with standard Botox injections.
- Trial name
- NCT00773253
- Testing
- Botulinum toxin A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Cervical Dystonia Adults ,, Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
ASIS for Botox in Cervical Dystonia
Botox acts on nerve endings, yet there are no nerve endings inside the muscle, where they are typically injected. All nerves terminate on the fascia, where ASIS device can precisely deliver Botox by creating that subdermal…
- Trial name
- ASISinCD (NCT02074293)
- Testing
- Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- li nguyen
Cervical Dystonia
Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
To determine the efficacy and safety of Botulax® in treatment of cervical dystonia
- Trial name
- NCT04171258
- Testing
- Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hugel
Cervical Dystonia
Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia
The primary goal of this clinical trial is to examine the effects of cervical vibrotactile stimulation intensity on abnormal head posture in people with cervical dystonia.
- Trial name
- (CD-VTS) (NCT07245615)
- Testing
- cervical vibrotactile stimulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cervical Dystonia, Primary
Effects of Botulinum Toxin on Muscle and Brain Activity
This study will look into the effects of Botulinum Toxin in patients with primary cervical dystonia. The effects will be determined by neck muscle activity measurements and brain function activity measurements.
- Trial name
- NCT02837185
- Testing
- Botulinum Toxin injection, Physiological measures
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cervical Dystonia
Daily Dystonia Practice - A Trial to Investigate NT 201, the Duration of Treatment Effect After One Injection Session and in Long-term Treatment in Cervical Dystonia
The aim of this study is to confirm efficacy and safety of NT 201 (Xeomin®, also known as IncobotulinumtoxinA) after one injection session and to determine the efficacy and safety profile and the duration of treatment effect of…
- Trial name
- NCT00541905
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia, Blepharospasm
A Retrospective Chart Review of BOTOX® and Xeomin® for the Management of Cervical Dystonia and Blepharospasm
This study is a retrospective chart review to evaluate the doses of botulinum Type A toxins BOTOX® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA) used for the treatment of Cervical Dystonia and Blepharospasm in clinical…
- Trial name
- NCT02245958
- Testing
- No Intervention
- Where
- 2 sites in Mexico, United Kingdom
- Volunteers
- 44 people
- Sponsor
- Allergan