Clinical trials: Dystonia, Primary
Dystonia, Primary
Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate…
- Trial name
- AGENT10 (NCT03351218)
- Testing
- Behavioral testing - computerized tasks
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Blepharospasm, Focal Dystonia
Brain Stimulation to Treat Blepharospasm or Meige Syndrome
This research study will examine whether magnetic or electrical stimulation of the brain can improve the involuntary closure of the eyelids in patients with blepharospasm or Meige syndrome; conditions that belong to a group of…
- Trial name
- NCT00411255
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Functional Connectivity in Primary Focal Dystonia
In this study we are looking at primary focal dystonias, including dystonias of the limbs, eyes, jaw or face, neck, and vocal chords.
- Trial name
- NCT01761903
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Tremor, Essential
Effectiveness and Reliability of Hypnosis in Stereotaxy
In certain neurosurgical procedures, the use of a stereotaxic frame is required. It is then possible to set a precise target (depending of the type of the surgery) to be reached by the surgeon.
- Conditions
- Parkinson Disease, Tremor, Essential, Dystonia, Primary
- Trial name
- ERST (NCT03074422)
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Dystonia, Primary, Dysarthria
Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular
To better define the clinical characteristics of oromandibular dystonia, we aimed to study voice, speech and swallowing disorders in idiopathic oromandibular We planned to include consecutive patients followed in Lille Movement…
- Conditions
- Dystonia, Primary, Dysarthria, Dysphonia, Dysphagia
- Trial name
- DOM (NCT03380676)
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Primary Dystonia
Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for Pallidal Deep Brain Stimulation
The aim of the study is to compare the efficacy and the safety profile of the newly introduced interleaving stimulation mode to those of the standard double monopolar stimulation mode during pallidal deep brain stimulation of…
- Trial name
- NCT01497639
- Testing
- Interleaving stimulation mode (Medtronic), Double monopolar stimulation mode (Medtronic)
- Where
- Hungary
- Volunteers
- 34 people
- Sponsor
- University of Pecs
Dystonia, Healthy
Brain Anatomy in Dystonia
This study will use high-resolution magnetic resonance imaging (MRI) to look for subtle differences in brain anatomy between patients with focal hand dystonia (also called writer s cramp) and healthy normal volunteers.
- Trial name
- NCT00031369
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Cervical Dystonia
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
The purpose of this research study is to determine the physical brain changes in people with cervical dystonia after deep brain stimulation (DBS) surgery and as compared to healthy controls.
- Trial name
- NCT01671527
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease, Multiple System Atrophy
Research of Biomarkers in Parkinson Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Huntington Disease
- Trial name
- Genepark (NCT00465790)
- Where
- 5 sites in Croatia, France and 2 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dystonia, Dystonic Cerebral Palsy
Enhancing Sensorimotor Processing in Children With Dystonia
Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury.
- Conditions
- Dystonia, Dystonic Cerebral Palsy, Dystonia, Secondary, Dystonia, Primary
- Trial name
- NCT05612464
- Testing
- No intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King's College London
Cervical Dystonia
Botox for Cervical Dystonia Following EMG Mapping
The purpose of this study is to determine how to improve treatment of patients with cervical dystonia who have not been helped with standard Botox injections.
- Trial name
- NCT00773253
- Testing
- Botulinum toxin A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Dystonia
Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia
The purpose of this study is to evaluate the efficacy and safety of bilateral deep brain stimulation of the internal globus pallidus for treating idiopathic generalized or severe segmental dystonia.
- Trial name
- NCT00142259
- Testing
- Deep brain stimulation of the internal globus pallidus
- Where
- 8 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- German Parkinson Study Group (GPS)
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Cervical Dystonia, Primary
Computer Modelling of the Cervical Spine Movements in Cervical Dystonia
Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia.
- Trial name
- STICOB (NCT02894359)
- Testing
- cone beam imagery of cervical spine
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dystonia, Primary
Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia
Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS).
- Trial name
- LICIdystonie (NCT03381456)
- Testing
- LICI
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Dystonia, Dystonia; Idiopathic
Dystonia Genotype-Phenotype Correlation
The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to…
- Conditions
- Dystonia, Dystonia; Idiopathic, Dystonia, Primary, Dystonia, Secondary
- Trial name
- NCT03428009
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Dystonia, Primary
An Open-label Study to Define the Safety, Tolerability and Clinical Activity of Deutetrabenazine (AUstedo) in Adult Study Subjects With DYsTonia
This is a single-center, open-label study of AUSTEDO in study subjects with dystonia. The study will provide preliminary experience of the safety, tolerability, and clinical activity of AUSTEDO in study subjects with dystonia.
- Trial name
- AUDYT (NCT04173260)
- Testing
- Deutetrabenazine 6 MG
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania