Clinical trials: Dystonic Disorder
Focal Dystonia
Neurophysiology of Task-Specificity of Focal Hand Dystonia
This study will examine how the brain coordinates movement in patients with focal hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00309010
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia
Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia
This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or…
- Trial name
- NCT07690514
- Testing
- LIFUS - GPi Active, LIFUS - DN Active
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Robert Chen
Spasmodic Torticollis
Efficacy and Safety of Two Different Botulinum Toxin Type A Treatments for Moderate to Severe Cervical Dystonia
The purpose of this study is to compare two types of botulinum toxin type A to treat the involuntary muscle contractions in the neck
- Trial name
- NCT00432341
- Testing
- botulinum toxin type A
- Where
- 3 sites in Argentina, Australia and 1 more
- Volunteers
- 54 people
- Sponsor
- Allergan
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Cervical Dystonia, Blepharospasm
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Our hypothesis is that botulinum toxin injections (with onabotulinum toxin, incobotulinum toxin, and abobotulinum toxin) given at 10-week or shorter intervals for the indication of treatment of muscle spasms associated with…
- Conditions
- Cervical Dystonia, Blepharospasm, Limb Dystonia, Hemifacial Spasm
- Trial name
- NCT05103202
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson Disease, Dystonia
Spine MRI in Patients With Deep Brain Stimulation (DBS)
Magnetic resonance imaging (MRI) of patients implanted with deep brain stimulation (DBS) is under strict safety guidelines. Depending on the body part being imaged, the safety may vary.
- Conditions
- Parkinson Disease, Dystonia, Depression, Spinal Stenosis
- Trial name
- NCT03753945
- Testing
- MRI of the spine
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Laryngeal Dystonia
tDCS for Laryngeal Dystonia
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
- Trial name
- NCT06830174
- Testing
- Starstim system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Cervical Dystonia
Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
To determine the efficacy and safety of Botulax® in treatment of cervical dystonia
- Trial name
- NCT04171258
- Testing
- Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hugel
Limb Dystonia, Idiopathic Dystonia
Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia
The goal of this clinical trial is to find out if a non-invasive procedure called focused ultrasound can safely and effectively treat limb dystonia in adults who have not improved with medications or botulinum toxin injections.
- Conditions
- Limb Dystonia, Idiopathic Dystonia, Medication-refractory Dystonia, Dystonia, Focal
- Trial name
- FUTURE (NCT07168850)
- Testing
- Exablate MR-guided Focused Ultrasound Pallidotomy
- Where
- 4 sites in Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Focal Dystonia
Motor Training to Treat Hand Dystonia
This study will evaluate the effect of motor training on focal hand dystonia in people with writer's cramp and will examine whether this training affects excitability of the motor cortex of the brain.
- Trial name
- NCT00021853
- Testing
- constraint-induced movement therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia
Static Graviceptive Functions in Patients With Cervical Dystonia (CD)
The purpose of this experimental pilot study is to test the effect of normalization of the head position on the sense of balance at patients with cervical dystonia under routine botulinum toxin treatment.
- Trial name
- NCT01180270
- Where
- Austria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kirsten Elwischger
Parkinson's Disease, Foot Dystonia
Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Foot dystonia is frequently observed in patients suffering from Parkinson'disease. It is characterized by an abnormal involuntary movement which is very uncomfortable (difficult to walk) and painful for the patient.
- Trial name
- RBHP 2008 (NCT00909883)
- Testing
- Botulinum Toxin: Xeomin
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Meige Syndrome
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies.
- Trial name
- NCT06912282
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Torticollis
A Prospective, Observational Study of Patients With Cervical Dystonia (Dystonie) Treated With OnabotulinumtoxinA
This is an observational study to assess health-related quality of life in patients with cervical dystonia (dystonie) treated with OnabotulinumtoxinA per routine clinical practice.
- Trial name
- NCT01655862
- Testing
- OnabotulinumtoxinA
- Where
- 8 sites in Canada
- Volunteers
- 62 people
- Sponsor
- Allergan
Parkinson's Disease, Essential Tremor
RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)
The purpose of this study is to assess the recharge feature of the Activa RC System in patients who are receiving Deep Brain Stimulation (DBS) for Parkinson's Disease (PD), Essential Tremor (ET), or dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- RECHARGE (NCT00998660)
- Testing
- Activa RC
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Parkinson Disease, Dystonia
In Vivo Measurement of the Accuracy of the "Neurolocate" Module of the Neurosurgical Robot "Neuromate" in Its Application to Deep Brain Stimulation
The purpose of this study is to evaluate the accuracy of the Neurolocate recording system of the neurosurgical robot Neuromate, marketed by Renishaw, in order to optimize surgical procedures, costs and patient comfort.
- Conditions
- Parkinson Disease, Dystonia, Tremor
- Trial name
- NEUROLOCATE (NCT04712552)
- Testing
- deep brain stimulation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Movement Disorders, Parkinson Disease
A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling
The Infinity MRI PMCF was conducted as an international, multicenter, observational, prospective, single-arm, post-market clinical follow-up (PMCF) study.
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- NCT03884231
- Testing
- Infinity DBS System with MR Conditional labelling
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 74 people
- Sponsor
- Abbott Medical Devices
Focal Dystonia
Brain Changes in Patients With Focal Hand Dystonia
This study will examine how chemical changes in the brain produce symptoms of hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00306865
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia
Study of the Oral Treatment MTR-601 in Cervical Dystonia
Study MTR-601-201 is an 8-week, randomized, placebo-controlled study to examine the safety, tolerability, and efficacy of MTR-601 in participants with cervical dystonia.
- Trial name
- NCT06830642
- Testing
- MTR-601
- Where
- 17 sites in United States
- Volunteers
- 38 people
- Sponsor
- Motric Bio
Cervical Dystonia
Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia
This Open-label Extension trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults.
- Trial name
- NCT04871451
- Testing
- ABP-450
- Where
- 20 sites in United States
- Volunteers
- 51 people
- Sponsor
- AEON Biopharma, Inc.