Clinical trials: E-cigarettes
Electronic Cigarettes
The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
The purpose of this study is to determine differences in nicotine delivery, user behaviors, subjective effects, and physiological effects, when cigarette smokers use an electronic cigarette with different nicotine (and sweetener)…
- Trial name
- NCT03861078
- Testing
- Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Electronic Cigarette Use
The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment
The purpose of this research study is to determine if ethanol-containing e-cigarettes impact ethanol breath, blood or oral fluid tests, field sobriety tests, or other tests of sobriety.
- Trial name
- NCT04522973
- Testing
- Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
Effects of Menthol in E-cigarettes on Smoking Behaviors
The overall goal of this proposal is to understand the relationship between nicotine metabolism and menthol flavor in e-cigarettes on smoking behavior in smokers.
- Trial name
- NCT04521647
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use
Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes
The primary goal of this study is to examine whether cigarette smokers can reduce their use of conventional, combustible cigarettes by switching to a Standardized Research E-Cigarette (SREC); whether participants can maintain…
- Trial name
- NCT03277495
- Testing
- Brief behavioral counseling
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Vaping, E-Cig Use
A Study of Cytisinicline for Vaping Cessation in Adult Smokers
This placebo-controlled Phase 2 study is being conducted at sites within the United States to evaluate the efficacy and safety profile of 3 mg cytisinicline administered TID for 12 weeks for vaping cessation.
- Trial name
- ORCA-V1 (NCT05431387)
- Testing
- cytisinicline, Behavioral support
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Achieve Life Sciences
Adolescent Behavior, Tobacco Use
Pittsburgh and Rural Area High School Tobacco Prevention
This research project will explore the feasibility and acceptability of a web-based media literacy tobacco prevention program. The project will be conducted with 9th graders in two schools in the Pittsburgh area.
- Conditions
- Adolescent Behavior, Tobacco Use, E-Cig Use
- Trial name
- NCT05081843
- Testing
- AD IT UP media literacy intervention, Usual health education curriculum
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Volunteers
A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes
The purpose of this study is to assess changes in exposure to selected harmful and potentially harmful substances related to tobacco/nicotine use when adult smokers switch from their usual brand of combustible cigarettes to the…
- Trial name
- NCT04019626
- Testing
- Continue-smoking, myblu Tobacco 2.5%, myblu Tobacco 4.0%
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Fontem Ventures BV
Nicotine Use Disorder
Effects of E-cigarette Flavors on Youth TCORS 2.0
This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.
- Trial name
- NCT03634839
- Testing
- Flavoring Agents, Nicotine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Mental and Behavioral Disorders, Withdrawal State
Effect of the Electronic Cigarette on Withdrawal Symptoms
Study rationale: Sensory/behavioural elements of smoking play a role in smoking behaviour and may have a potential to assist smoking cessation.
- Trial name
- ECIG24 (NCT01454362)
- Testing
- Nicotine
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Pulmonary Disease, Chronic Obstructive, Cigarette Smoking
E-Visit for COPD and Smoking Cessation
The goal of this work is to develop, refine, and pilot test an electronic visit (e-visit) to: 1) deliver smoking cessation treatment to adults at risk for COPD and 2) to improve rates of COPD early detection and accurate…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
- Trial name
- NCT04155073
- Testing
- smoking cessation, early COPD detection, electronic visit, Treatment As Usual
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Medical University of South Carolina
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Cigarette Smoking, Tobacco Use
Electronic Cigarette Use in Young Adult Men and Women
This one-year pilot study of 30 non-treatment seeking young adult e-cigarette/combustible tobacco product dual users (15 males/15 females) will use smartphone-based ecological momentary assessment (EMA) to gather real-time data…
- Trial name
- NCT03089541
- Testing
- Survey Arm
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking-Related Carcinoma
Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study
This clinical trial studies the effect of free-base compared with nicotine salt based e-liquids on electronic cigarette (EC) puffing behavior, abuse liability, and deposition and absorption of nicotine in the respiratory tract…
- Trial name
- NCT05455086
- Testing
- Cigarette Smoking, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Nicotine E-Cigarette Use
Water Content in E-Liquids
This study looks at the effect of manipulating the water concentration of certain e-liquids on sensory perception.
- Trial name
- NCT05257109
- Testing
- Water Concentration 1, Water Concentration 2, Water Concentration 3
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- BuZonE (NCT04388319)
- Testing
- Zonisamide, Bupropion, Halo G6 e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation
Varenicline for Treatment of E-cigarette Dependence
Varenicline is used to treat tobacco use dependence. It helps reduce cravings for tobacco use and decreases the pleasurable effects of cigarettes and other tobacco products.
- Trial name
- NCT05541497
- Testing
- Varenicline Tartrate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Electronic Cigarettes
Assessment of Two New Electronic Cigarettes in Cigarette Smokers
The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use an two new electronic cigarette devices (JUUL and IQOS) relative…
- Trial name
- NCT03435562
- Testing
- JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Tobacco Use Disorder
Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace
This is a one-session study that participants complete remotely including consent, Experimental Tobacco Marketplace purchases, and assessments to examine the effects of cigarette and e-cigarette flavors on cigarette demand and…
- Trial name
- NCT05110872
- Testing
- Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- Virginia Polytechnic Institute and State University