Clinical trials: E-cigarettes
Tobacco Use
Electronic Cigarette Unit Price Manipulations in the Experimental Tobacco Marketplace
Electronic cigarettes (e-cigarettes) may be a safer alternative to conventional cigarettes and are available in a broad range of nicotine strengths.
- Trial name
- NCT03843047
- Testing
- 3 mg/mL nicotine strength e-liquid, 6 mg/mL nicotine strength e-liquid, 12 mg/mL nicotine strength e-liquid
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Tobacco Use
Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior
This study will investigate within-person changes in smoking behavior when current menthol smokers are switched to non-menthol cigarettes and either tobacco or menthol flavored e-cigarettes.
- Trial name
- NCT04009850
- Testing
- Cigarette Brand Switching, E-cigarette Flavor
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Yale University
E-Cig Use
Respiratory Effects of E-Cigarettes in Obese Youth
To determine vaping behaviors and respiratory function in obese and nonobese youth e-cigarette users.
- Trial name
- RESEC (NCT05869318)
- Testing
- ECIG own, ECIG Vuse
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Smoking Cessation
The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers
The goal of this clinical trial is to evaluate effectiveness of using e-cigarettes as harm reduction strategy for smoking cessation and decreasing risk of diseases in heavy smokers.
- Trial name
- NCT05639790
- Testing
- Electronic cigarettes + Health Counselling, Health Counselling
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shenzhen Smoore Technology Limited
Cigarette Smoking-Related Carcinoma
Website Smoking Cessation Intervention for the Promotion of Smoking Cessation in Low-Income Veterans
This phase I trial studies how well a new electronic (e)-health smoking cessation program (called Vet Flexiquit) works in promoting smoking cessation in low-income veterans who may or may not be ready to quit smoking.
- Trial name
- NCT04502524
- Testing
- Smoking Cessation Intervention (New website), Smoking Cessation Intervention (Standard of care website), Health Education
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Vaping Behaviors
The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book
This is a randomized controlled trial to assess the feasibility, acceptability, and preliminary impact of The Villainous Vape, a vaping prevention comic book, among adolescents.
- Trial name
- NCT07737080
- Testing
- Health Impacts of E-cigarettes, Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping, The Villainous Vape
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Vaping
Responses to Message Source and Presentation Using Psychophysiology
The goal of this clinical trial is to use psychophysiological methods to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for…
- Trial name
- NCT06269003
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Vaping
Modeling Stress-precipitated Vaping Behavior
The primary aims of this pilot study were to (1) initially validate the applicability of a human laboratory model of relapse initially developed for smokers to e-cigarette users; (2) to use this human laboratory model of lapse…
- Trial name
- NCT04522362
- Testing
- Control task and Trier Social Stress Task
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Clemson University
Vaping
Responses to E-cigarette Message Source and Presentation
The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who…
- Trial name
- NCT06274723
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Products, Cigarettes
Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes
The study is a pilot test of effectiveness of communication campaign ads on interest in quitting combustible cigarettes and e-cigarettes.
- Conditions
- Tobacco Products, Cigarettes, Electronic Cigarettes
- Trial name
- NCT07599462
- Testing
- communication
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Electronic Nicotine Delivery Systems
Cardiorespiratory Fitness and Health Parameters in E-cigarrete Users: Impact of a Short Term Pause in Consumption
Goal: Investigate the health effects of electronic cigarettes (e-cigarettes) and whether a short break from using them can improve health.
- Trial name
- EXERVAPE (NCT06474962)
- Testing
- Pause
- Where
- Brazil
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Participants, Tobacco Smokers
Evaluation of the Effect of a Nasal Allergen Challenge With Dermatophagoides Farinae Extract on Nasal Airway Inflammation in Allergic Individuals, Comparing E-cigarette Users to Cigarette Smokers and Non-smokers.
The purpose of this pilot study is to evaluate allergen-induced nasal airway inflammation following nasal application of Dermatophagoides farinae (Der f), or house dust mite, extract in e-cigarette users, cigarette smokers, and…
- Trial name
- Mitey Nose (NCT03023397)
- Testing
- Der f
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking Cessation
Impact of E-cigarette Nicotine Concentration on Compensation
The study will be the first to assess the impact of nicotine concentration on compensatory puffing (total inhaled volume), nicotine delivery, and switch patterns (percent exclusive EC, dual cig-EC, and cig only users) with an…
- Trial name
- NCT05887947
- Testing
- Electronic Cigarette with 5% Nicotine Concentration, Electronic Cigarette with 1.8% Nicotine Concentration
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Acute Lung Injury
The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction
To carry out a prospective cohort study of healthy volunteers, assessing differences between baseline pulmonary inflammation, response to LPS inhalation and endothelial function, as measured by flow mediated dilation between…
- Trial name
- SELECT (NCT02739438)
- Testing
- Electronic cigarette use, Cigarette use, Control group
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
E-cigarette Use
Sex Differences in the Vascular Effects of E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Trial name
- NCT06159608
- Testing
- Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Periodontal Diseases, Smoking
The Effect of Scaling and Root Planing on Oral Inflammatory Biomarkers Among E-cig Users and Non-smokers
Background/Aim: There are no studies that have compared the gingival crevicular fluid (GCF) levels of IL-1β in non-smokers (NS) and electronic nicotine delivery system (ENDS)-users before and after scaling and root planing (SRP)…
- Trial name
- ENDS-SRP (NCT05745324)
- Testing
- Scaling and root planing
- Where
- Kuwait
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Vaping
Feasibility of Treatment for Vaping Cessation
Researchers are gathering information on the feasibility of treating e-cigarette users with 12-weeks of varenicline (Chantix®) in assisting with stopping the use of e-cigarettes.
- Trial name
- VAPEscape (NCT04317300)
- Testing
- Varenicline, brief behavioral therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Volunteers
A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes
This study evaluates the overall performance of the currently-marketed MybluTM e-cigarette device and pods, as assessed by nicotine uptake, exposure to smoke constituents, safety and consumer satisfaction, over 8 days.
- Trial name
- NCT04430634
- Testing
- Myblu variant A, Myblu variant B, Myblu variant C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fontem US LLC
Heavy Metal Exposure From Vaping
Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users
This study investigates heavy metal exposure in young adults who use electronic cigarettes.
- Trial name
- NCT07215065
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center