Clinical trials: ECMO
Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe…
- Conditions
- Blood Loss Anemia, Extracorporeal Membrane Oxygenation Complication, Disability Physical, Cognitive Ability, General
- Trial name
- ROSETTA (NCT05814094)
- Testing
- Red Blood Cell Transfusion
- Where
- 2 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Anticoagulation
Growth of High-Quality Oxides on The Inner Surface of ECMO Circuit by ALD to Reduce Thrombus Formation
This study evaluate thermal ALD (T-ALD) and plasma-enhance ALD (PE-ALD) processes modified cardiopulmonary bypass (CPB) tubing to investigate anticoagulation properties.
- Trial name
- NCT03662594
- Testing
- ECMO
- Where
- Taiwan
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Community Acquired Pneumonia, Respiration Failure
A Molecular Toolkit for the Microbial Investigation of Severe Community Acquired Pneumonia
Severe community acquired pneumonia is common and associated with high mortality. Conventional microbiological diagnostics identify pathogens in approximately half of cases, which is inadequate for both clinical and…
- Conditions
- Community Acquired Pneumonia, Respiration Failure, Pneumonia
- Trial name
- S-CAP (NCT02963142)
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diaphragmatic Hernia
Fetoscopic Tracheal Balloon Occlusion in Left Diaphragmatic Hernia
Left diaphragmatic hernia detected during fetal life carries a high risk for postnatal lung failure due to lung underdevelopment and pulmonary hypertension.
- Trial name
- NCT00373438
- Testing
- Fetoscopic tracheal balloon occlusion
- Where
- Germany
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Antithrombin Deficiency Type 2
Response of Continuous Recombinant Antithrombin Infusion in Postcardiotomy ECMO Patients
The objective of this study will be to prospectively evaluate the response of a continuous infusion of recombinant human antithrombin concentrate (rhAT) (ATRYN®) to achieve and maintain the AT activity within a specified range in…
- Trial name
- NCT03090893
- Testing
- ATryn continuous infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Rate Variability
Heart Rate Variability in Extracorporeal Membrane Oxygenation (ECMO) Patients
National Taiwan University Hospital is the leading center for care of patients with extracorporeal membrane oxygenation (ECMO). The predictable factors associated with outcomes are still lacking in patients with the ECMO support.
- Trial name
- NCT01247727
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Burnout, Caregiver, Extracorporeal Membrane Oxygenation Complication
Impact of Extra Corporal Membrane Oxygenation Services on Burnout Development in Intensive Care Units.
The burnout phenomenon first came to clinical science 50 years ago. It is exponentially rising worldwide which prompted its discoverers to develop the most popular tool for its assessment, known as the Maslach burnout inventory…
- Conditions
- Burnout, Caregiver, Extracorporeal Membrane Oxygenation Complication, Intensive Care Unit
- Trial name
- burnout (NCT04620005)
- Testing
- Observational
- Where
- Qatar
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
ECMO, Training Effectiveness
Virtual Reality Training for ECMO Circuit Checks
Purpose of the Study: This investigation will examine whether a brief session with an immersive virtual-reality headset can prepare critical-care nurses to carry out an eleven-step extracorporeal membrane oxygenation circuit…
- Conditions
- ECMO, Training Effectiveness, Education Nursing, Educational Intervention
- Trial name
- HEALTH-ECMO-VR (NCT07138599)
- Testing
- Virtual Reality ECMO Simulation Training, Instructional Video of Certified Perfusionists on Performing a Circuit Check
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Cardiogenic Shock,, With ECMO or IABP Support,
The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25)
The study is to show the prognostic factor of HRV parameter and cardiac fibrosis markers in critical illness patients
- Conditions
- Cardiogenic Shock,, With ECMO or IABP Support,, With APACH II Score >25)
- Trial name
- NCT01993745
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Life Support Systems
Evaluation of Practices of ECMO or ECLS and Ethical Implications in France
Short-term circulatory support (ECMO/ECLS) has become a common emergency resuscitation support. Currently, the indication of the ECMO/ECLS relies more on clinic, biological and imagery arguments than on a real consensus.During…
- Trial name
- EVAPE (NCT04188886)
- Testing
- Practice survey
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier La Chartreuse
Hypoxia, Extracorporeal Membrane Oxygenation Complication
The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
This study will examine the pharmacokinetics of the various, routinely given antibiotics, sedatives, and opioids in patients undergoing venous-venous extra-corporal oxygenation (ECMO).
- Trial name
- ECMOPK (NCT03659513)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Learning Problem
Impact of Extracorporeal Membrane Oxygenation Care Strategy Application Development
The objective of this study was to develop an educational training App for ECMO care, and to apply a blended learning approach to improve the knowledge and skills of nurses.
- Trial name
- NCT06329505
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pei-Hung Liao
Cardiac Arrest
A Modified Delphi for ECPR Post Resuscitation Care
The objective of this study is to generate expert consensus statements on the management of out of hospital cardiac arrest (OHCA) patients treated with extracorporeal membrane oxygenation (ECMO) cardiopulmonary resuscitation…
- Trial name
- NCT06552312
- Testing
- Delphi Questionnaire
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sydney Local Health District
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support
The potential role of ATIII in achieving and maintaining adequate anticoagulation in pediatric patients on the heart-lung machine has recently taken on increased importance as caregivers strive to mitigate the risk for clinically…
- Trial name
- NCT02631174
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sickle Cell Disease, Cerebral Stroke
Cerebral Oxygen Metabolism in Children
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.
- Trial name
- COMIC (NCT04157179)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism
Cerebral Microemboli in Venoarterial ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is progressively used in critically ill patients with cardiac or respiratory failure as a bridging option for potential organ recovery.
- Conditions
- Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism, Cerebral Perfusion
- Trial name
- NCT02020759
- Testing
- Transcranial Doppler Ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Muscle Mass Loss
Effect of Neuromuscular Electrical Stimulation on Muscle Mass in ECMO Patients
The goal of this clinical trial study: is to determine the effectiveness of neuromuscular electrical stimulation in critically ill patients undergoing extracorporeal membrane oxygenation.
- Trial name
- NMES-ECMO (NCT07566702)
- Testing
- NMES, Conventional physiothrapy program
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre