Clinical trials: EDS
Ehler's Danlos Syndrome, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.
- Trial name
- NCT02712060
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Volunteers, Vascular Ehlers Danlos Syndrome
Non-Invasive Quantitative Imaging of Human Local Arterial Wall Elasticity Using Supersonic Shear Imaging
Arterial stiffness is associated with increased risk of cardiovascular events and death. Most of existing technique need dedicated device for arterial stiffness evaluation and indirect calculation of intra arterial pressure.
- Trial name
- ULTRAFASTECHO (NCT01096264)
- Testing
- SSI and SphygmoCor® evaluations
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Vascular Ehlers-Danlos Syndrome
Biomarkers in Vascular Ehlers-Danlos Syndrome
The purpose of this study is to determine whether patients with vascular Ehlers-Danlos syndrome present significant and specific changes of arterial endothelial and smooth muscular cell signalling/secretion, in comparison to…
- Trial name
- MEDIC (NCT02165085)
- Where
- France
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Risk
Clinical Trial on the Effects of Caffeine and Taurine From Energy Drinks (EDs) to Parameters of the Cardiovascular System in Humans
The aim of this study is to examine the safety and the effects of EDs at high doses, either alone or in combination with other risk factors such as alcohol intake, physical exercise and sleep deprivation, on cardiovascular…
- Trial name
- NCT01421979
- Testing
- Energy Drink, Taurine, Caffeine
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Ehlers-Danlos Syndrome, Stickler Syndrome
Studies of Heritable Disorders of Connective Tissue
Background: Heritable disorders of connective tissue are genetic conditions that can affect the skin and other parts of the body. They are related to mutations in genes that are responsible for building tissues.
- Conditions
- Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome
- Trial name
- NCT00270686
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Ehlers-Danlos Syndrome, Multiple Sclerosis
Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)
The investigators propose that evidence of chronic cerebrospinal venous insufficiency (CCSVI) may be evident in the vasculature of the fundus.
- Trial name
- NCT01356134
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Genetic Disease Investigators
Wrinkle, Elastic Skin
Straberi Epistamp Needling Treatment For Skin Rejuvenation
This pilot study will expand knowledge and application needling using the Epistamp device for the improvement of a new vitalized epidermal layer with new vibrant active cells, supported by more robust collagen and elastin fine…
- Conditions
- Wrinkle, Elastic Skin, Collagen Degeneration
- Trial name
- ESAA (NCT04742803)
- Testing
- Straberi Epistamp Microneedling Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universal Skincare Institute
Collagen Degeneration, Wrinkle
The Effects of Almond on Facial Skin Collagen and Wrinkles
Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.
- Conditions
- Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
- Trial name
- NCT06074276
- Testing
- Food: whole almonds, Food: non-nut snack
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
Validity of Somatosensori Remediation for Postural Control in the Treatment of Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
In the absence of a medical consensus, the current management of Ehlers-Danlos Syndrome hypermobility type (hEDS) remains very speculative That's why investigators want in this study to demonstrate the beneficial contribution of…
- Trial name
- VITALISED (NCT04020107)
- Testing
- Compressive garment and Somatosensori Remediation
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Ehlers-Danlos Syndrome, Anesthesia, Local
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers.
- Trial name
- NCT05603741
- Testing
- 0.9% Sodium Chloride Injection, Lidocaine Injection 2%
- Where
- Canada
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Ehlers-Danlos Syndrome, Classic
IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients
The investigators want to inject insulin-like growth factor-I (IGF-I) into the patella tendon of Ehlers-Danlos patients and healthy controls to evaluate the response in collagen synthesis.
- Trial name
- NCT01446783
- Testing
- mecasermin, Saline
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Collagen Degeneration, Wrinkle
The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal…
- Conditions
- Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
- Trial name
- NCT06571721
- Testing
- Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Standing Cognition and Co-morbidities of POTS Evaluation
The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.
- Trial name
- SCOPE (NCT03602482)
- Testing
- Standing, Supine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Ehlers-Danlos Syndrome (EDS)
Impact of Ehlers-Danlos Syndrome on Gynaecological Health
Dysmenorrhea is a common problem in gynaecology, significantly impacting patients' quality of life. Ehlers-Danlos syndrome (EDS) is associated with joint hypermobility, tissue fragility and chronic pain.
- Trial name
- GYNESED (NCT07151274)
- Where
- France
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Genetics Syndrome, Ehlers-Danlos Syndrome
Genetics of Ehlers-Danlos Syndrome
We are planning to collected blood and saliva for DNA extraction to use for genetic testing of children and adults with EDS and their relatives. Medical records from other institutions and clinical notes for visits in Dr.
- Trial name
- NCT03093493
- Testing
- Genotyping
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Boston University
Small Fiber Neuropathy, Fabry Disease
Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan
Sudoscan™ (Impeto Medical, Paris France) uses electrochemical skin conductance as a novel noninvasive method to detect sudomotor dysfunction.
- Conditions
- Small Fiber Neuropathy, Fabry Disease, Ehlers Danlos Syndrome, Mitochondrial Disease
- Trial name
- NCT02985710
- Testing
- Sudoscan, Skin biopsy, QSART
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS)
Two Point Discrimination
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of…
- Conditions
- Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), Amplified Musculoskeletal Pain Syndrome (AMPS), Low Back Pain
- Trial name
- TPD (NCT03686748)
- Testing
- Two-point discrimination training, One-point discrimination training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Enamel Demineralization, White Spot Lesions
Silver Nanoparticle-Coated Orthodontic Brackets for Preventing Enamel Demineralization
The goal of this clinical trial is to learn whether orthodontic brackets coated with silver nanoparticles can help prevent early damage to tooth enamel in people receiving fixed braces.
- Trial name
- AgBracket (NCT07707336)
- Testing
- Silver Nanoparticle-Coated Stainless Steel Orthodontic Brackets, Conventional Stainless Steel Orthodontic Brackets
- Where
- United Arab Emirates
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ajman University
Hypermobile Ehlers-Danlos Syndrome
Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome.
Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to…
- Trial name
- ProprioRespi (NCT05000151)
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hakimi Adrien
Ehlers-Danlos Syndrome, Healthy Subjects
ABVN Phase 2 - EDS Wearable Device
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT07856459)
- Testing
- ML1101 Stimulus Isolator, Cardiowatch Bracelet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Indiana University