Clinical trials: EMBRYO IMPLANTATION
Incisional Hernia, Peritonitis
Prophylactic Implantation of Biologic Mesh in Peritonitis
Patients undergoing emergency surgery for peritonitis are at increased risk of abdominal wall-related complications. In patients with peritonitis the risk of incisional hernia (IH) is extremely elevated.
- Trial name
- NCT04681326
- Testing
- biological prosthesis
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Aortic Valve Stenosis
Protection by Remote Ischemic Preconditioning During Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) has rapidly been adopted into clinical practice, but concerns have been raised regarding periprocedural complications like e.g. myocardial injury, stroke or acute kidney injury.
- Trial name
- NCT02080299
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital, Essen
Cataracts
Clinical Investigation of Corneal Incision Size After Intraocular Lens (IOL) Implantation
The purpose of this study is to compare corneal incision size after IOL implantation with the use of one of four IOL delivery systems (three preloaded IOL delivery systems and one manually loaded IOL delivery system).
- Trial name
- NCT02826421
- Testing
- UltraSert Preloaded Delivery System, iTec Preloaded Delivery System, iSert Preloaded Delivery System
- Volunteers
- 114 people
- Sponsor
- Alcon Research
Aortic Stenosis
Neuropsychological Testing in Patients Undergoing Transvascular Aortic Valve Implantation
The purpose of this study is to examine the neuropsychological effects of transvascular aortic valve implantation (TAVI). Patients undergoing TAVI usually suffer from congestive heart failure and low cardiac output which may…
- Trial name
- TAVIPSYCH (NCT01648309)
- Testing
- Neuropsychological testing
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Hearing Loss
ICF in Cochlear Implant Users
The current project proposes a multi-center prospective follow-up cohort study aiming to realize an international framework to classify human functioning and disability in Cochlear Implant (CI) recipients using a standardized ICF…
- Trial name
- NCT04611555
- Where
- 5 sites in Australia, Belgium and 3 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Inguinal Hernia
The Immunologic Reaction to Polypropylene Mesh in Inguinal Hernioplasty
The notable development and diffusion of prosthetic surgery of the abdominal wall over the last few years has led to the introduction of light weight meshes.
- Trial name
- NCT01090284
- Testing
- Inguinal hernioplasty
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital, Catania
Sterility, Placenta; Implantation
A Lifestyle Intervention to Improve in Vitro Fertilization Results
Embryo adhesion and placentation depend on tissue plasminogen activator (tPA)-mediated activation of brain-derived neurotrophic factor, vascular endothelial growth factor and other growth factors, formation of hemidesmosomes, and…
- Conditions
- Sterility, Placenta; Implantation, Risk Reduction Behavior, Lifestyle
- Trial name
- W+D (NCT02648555)
- Testing
- Daily walking, Dietary recommendations
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Corneal Astigmatism in Cataract Patients and Previous DALK
Effectiveness of Toric Intraocular Lenses for Treating Corneal Astigmatism in Patients With Cataract and Previous DALK
the purpose of this study was to assess the efficacy of custom made toric intraocular lens implantation in patients with simultaneous post-DALK high corneal astigmatism and cataract.
- Trial name
- NCT03398109
- Testing
- Customized toric IOL for post-DALK atigmatism
- Volunteers
- 10 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Bone Cysts, Bone Atrophy
Gene-activated Bone Substitute for Maxillofacial Bone Regeneration
The purpose of this study is to evaluate the safety and efficacy of the gene-activated bone substitute consisting of octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor (VEGF) for maxillofacial bone…
- Conditions
- Bone Cysts, Bone Atrophy, Bone Deformity, Bone Fracture
- Trial name
- NCT03076138
- Testing
- Gene-activated matrix (OCP + plasmid DNA with VEGF gene)
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Histograft Co., Ltd.
Infection, Driveline Heart-assisted Device Related Infection
Postoperative Infections and Immune Profiles in Patients Undergoing LVAD Implantation
The objective of this study is to investigate the incidence of infection and changes in the immune profile following left ventricular assist device implantation.
- Conditions
- Infection, Driveline Heart-assisted Device Related Infection, Pneumonia, Sepsis
- Trial name
- NCT07255716
- Testing
- none intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pacemaker Implantation, Pocket Hematoma and Bleeding
Pocket Haematoma Prevention in Patients Who Required Implantation/Replacement of a Pacemaker or Implantable Cardiac Defibrillator. The PHP Study.
The aim of this study is to demonstrate the efficacy of fibrin sealant (Tissucol-Baxter) in preventing pocket haematoma and subsequent complications in patients undergoing pacemaker or ICD implantation/replacement which cannot…
- Conditions
- Pacemaker Implantation, Pocket Hematoma and Bleeding, Antiplatelet Therapy or Oral Anticoagulants
- Trial name
- PHP (NCT01127984)
- Testing
- tissucol, drainage system
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Careggi Hospital
Dental Implants, Maxillary Diseases
"Computer-Guided vs Freehand Zygomatic Implant Placement
This randomized trial compares computer-guided versus free-hand zygomatic implant placement in patients with atrophic maxillae or maxillary defects.
- Trial name
- NCT06925438
- Testing
- Computer-guided zygomatic implant system, free-hand zygomatic implant placement
- Where
- 2 sites in Egypt
- Volunteers
- 8 people
- Sponsor
- Al-Azhar University
Cataract, Lenses
A Comparison of the Visual Performance of Trifocal Versus Extended Depth of Focus Intraocular Lenses
We are conducting a trial evaluating the performance of trifocal versus extended depth of focus intraocular lenses. These lenses will be implanted in otherwise healthy individuals with visual problems due to bilateral cataracts.
- Conditions
- Cataract, Lenses, Visual Impairment
- Trial name
- NCT03726606
- Testing
- Intraocular lens
- Volunteers
- 36 people
- Sponsor
- Hashmanis Hospital
Volume Loss in the Dorsum of the Hand
Radiological Evaluation of Radiesse Implantation in the Hands
The objective of this study is to provide a preliminary assessment of the radiographic appearance of Radiesse material that has been injected into the dorsum of the hands.
- Trial name
- NCT02949921
- Testing
- Radiesse injectable implant and 2% lidocaine HCL
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Transcatheter Aortic Valve Implantation, Permanent Pacemaker Implantation
A Multimodal Strategy to Screen for and Rule-Out Delayed High-Grade Conduction Disturbances After TAVR
Electrocardiogram (ECG)-based algorithms have been proposed to guide post-TAVI conduction management; however, their ability to predict clinically relevant delayed conduction disturbances remains limited.
- Conditions
- Transcatheter Aortic Valve Implantation, Permanent Pacemaker Implantation, Right Bundle-Branch Block, Left Bundle-Branch Block
- Trial name
- LATETAVI (NCT07414485)
- Testing
- retrospective health data collection
- Where
- France
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Long Bone Non-Union
Study on Autologous Osteoblastic Cells Implantation in Hypotrophic Non-Union Fractures
Fracture healing is a complex physiological process caused by interaction of cellular elements, cytokines and signaling proteins, which results in the formation of new bone (Gerstenfeld et al., 2003).
- Trial name
- NCT01756326
- Testing
- PREOB® Implantation, Bone Autograft
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 5 people
- Sponsor
- Bone Therapeutics S.A
Cataract, Lens Opacities
PMCF Study on Monofocal Toric IOL (PODEYE TORIC) in Asia
This is a single-center, prospective, open-label PMCF study whereby patients undergoing routine cataract surgery will have mono- or bilateral implantation of hydrophobic acrylic monofocal toric intraocular lens PODEYE TORIC…
- Conditions
- Cataract, Lens Opacities, Astigmatism
- Trial name
- PHY2102 (NCT04778501)
- Testing
- IOL implantation experimental
- Where
- Philippines
- Volunteers
- 45 people
- Sponsor
- Beaver-Visitec International, Inc.
Tunisian Patients Already Implanted With a TAVI
Tunisian Registry of Trans Catheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) has emerged as a transformative therapy for patients with severe aortic stenosis, particularly those designated high-risk or inoperable for traditional surgical valve replacement.
- Trial name
- TAVI-TN (NCT06503965)
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Defibrillator, Tricuspid Valve Regurgitation
Early Feasibility Study of 3930M Defibrillation Lead Implantation Via the Middle Cardiac Vein in Patients With Tricuspid Valve Regurgitation
Prospective, single center, early feasibility study designed to evaluate the initial safety and device performance of the Medtronic 3930M Lead when implanted via the Middle Cardiac Vein in patients with Tricuspid Valve…
- Trial name
- MCV3930 EFS (NCT07811609)
- Testing
- Defibrillator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Heart Disease
Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES)
The purpose of this study is to evaluate the differences of wall shear stress distribution among different types of drug-eluting stents and its impact on vessel healing evaluated by intravascular optical coherence tomography…
- Trial name
- NCT01942044
- Testing
- Promus element, Xience prime, and Nobori
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kobe University
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