Clinical trials: EMBRYO IMPLANTATION
Implantation, Embryo
Longitudinal Clinical Observation of a Digital Twin Model for Blastocyst Evaluation in IVF Clinics
This study aims to develop and validate a non-image, multimodal digital twin model of the human blastocyst using fully de-identified clinical, laboratory, molecular, biochemical, and long-term follow-up data obtained during…
- Trial name
- IVFDT (NCT07305480)
- Testing
- Digital Twin Computational Modeling
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Ukraine Association of Biobank
Age-related Cataract
IOL-capsular Complex After Different Intraocular Lenses Implantation in Patients With High Myopia
The IOL-capsular complex is formed after cataract surgery and intraocular lens (IOL) implantation. Early postoperative mechanical wrapping of the anterior and posterior capsules plays a significant role in preventing IOL…
- Trial name
- NCT05255796
- Testing
- one-piece, plate-haptic
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wenzhou Medical University
Presbyopia, Refractive Errors
Premium Monovision Versus Other Types of Monovision and Bilateral Trifocal Implantation.
Primary objective of this study was to compare the efficacy of premium monovision with Restor and Panoptix, against other prevalent monovision techniques and against bilateral Panoptix implantation in a sample of patients…
- Conditions
- Presbyopia, Refractive Errors, Cataract
- Trial name
- NCT04618380
- Testing
- bUD-VA,bUN-RA, bUI-RA, bUI-CPS, bUN-CPS, contrast sensitivity
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- Democritus University of Thrace
Recurrent Unexplained Implantation Failure
Certolizumab in Recurrent Implantation Failure (RIF)
Recurrent implantation failure (RIF), defined as the absence of clinical pregnancy after the transfer of three good-quality embryos, concerns up to 40% of IVF couples and is associated with a low success rate.
- Trial name
- CERTIFY (NCT05930613)
- Testing
- Certolizumab (CIMZIA® ; TNF-α antagonist)
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
BPH, BOO - Bladder Outflow Obstruction
Long Term Safety and Efficacy of Butterfly Medical Prostatic Retraction Device in Benign Prostatic Hyperplasia (BPH) Patients Who Completed 12 Months of Follow-Up Post Implantation (Continuation Study for Study BM-011-IL)
This study evaluates the long term safety and efficacy of use of the Butterfly Medical's prostatic retraction device in Benign Prostatic Hyperplasia (BPH) Patients.
- Conditions
- BPH, BOO - Bladder Outflow Obstruction, Enlarged Prostate (BPH)
- Trial name
- NCT05330520
- Testing
- Butterfly Medical Prostatic Retraction Device ("the Butterfly device") removal/replacement
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Butterfly Medical Ltd.
Aortic Valve Stenosis
Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve
There is limited experience for the balloon expandable THV (transcatheter heart valve) on the need for predilation (ballon aortic valvuloplasty, BAV).
- Trial name
- EASE-IT (NCT02127580)
- Testing
- BAV, without BAV
- Where
- 7 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Aortic Valve Stenosis, Aortic Valve Insufficiency
Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry
In the past years a substantial shift away from mechanical heart valves occurred and bioprosthetic heart valves claimed majority of market shares irrespective of patients' age.This indicates that population with failed surgical…
- Conditions
- Aortic Valve Stenosis, Aortic Valve Insufficiency, Ventricular Outflow Obstruction, Left
- Trial name
- NCT03361046
- Testing
- Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI)
- Where
- 12 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Warsaw
Coronary Artery Disease
Transepicardial With Transseptal Autologous CD 133+ Bone Marrow Cell Implantation in Patient Following CABG Surgery
Heart Failure has several etiologies and one of them is coronary artery disease. Coronary artery bypass grafting (CABG) is one of revascularizations method which has been used for decades in coronary artery disease theraphy.
- Trial name
- NCT02870933
- Testing
- Transepicardial with Transseptal CD 133+ Implantation
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Advanced Keratoconus
Isolated Bowman Layer Graft for Reducing and Stabilizing Advanced Keratoconus
To evaluate the efficacy of mid-stromal implantation of an isolated Bowman layer graft, to reduce and stabilize ectasia in eyes with advanced keratoconus
- Trial name
- NCT01686906
- Testing
- Bowman layer graft implantation
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Dental Implantation, Endosseous
Evaluation of the Effect of Injectable Platelet Rich Fibrin on Stability of Dental Implant for Narrow Ridges
the main aim of the study is to evaluate the secondary implant stability when using dental implants with injectable platelet rich fibrin accompanied by non-autogenous bone graft material in narrow ridge cases versus…
- Trial name
- NCT05427643
- Testing
- study group, control group
- Where
- Iraq
- Volunteers
- 13 people
- Sponsor
- Sora Salam Majeed
Recurrent Rectal Cancer, 125I Seeds Implantation
CTV Exploration of 3D-PT Assisted CT-guided I-125 Seeds Implantation for Recurrent Rectal Cancer
This study is to explore the progression-free survival time (PFS) , overall survival time (OS), quality of life and side effects between two different clinical target volumes in the treatment of 3D printing template-assisted…
- Conditions
- Recurrent Rectal Cancer, 125I Seeds Implantation, Clinical Target Volume
- Trial name
- NCT04710589
- Testing
- CTV
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Chronic Heart Failure
Image Fusion of SPECT MPI and Fluoroscopy Venography to Guide LV Lead Placement for Improved CRT Response (GUIDE-CRT II)
CRT response will be significantly better using image fusion of SPECT MPI and fluoroscopy venogram to guide LV lead placement at the latest activation segment without scar than standard-of-care implantation.
- Trial name
- GUIDE-CRT (NCT03125720)
- Testing
- Image fusion of SPECT MPI and fluoroscopy venography
- Where
- 14 sites in China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Bradycardia, Left Bundle Branch Area Pacing
Safety and Performances of the LINEA Cardiac Pacing Lead Optimized for the Implantation in Interventricular Septum
The purpose of the clinical investigation is to evaluate the safety and performances of the new LINEA cardiac pacing lead, intended for placement at the interventricular septum.
- Conditions
- Bradycardia, Left Bundle Branch Area Pacing, Left Bundle Branch Pacing
- Trial name
- STARLIGHT (NCT07342608)
- Testing
- Use of LINEA cardiac pacing lead
- Where
- 14 sites in Belgium, France and 3 more
- Volunteers
- 450 people
- Sponsor
- MicroPort CRM
Coronary Artery Disease
Non-inferiority Trial to Assess the Safety and Performance of the Evolution Coronary Stent
The purpose of the EVOLVE Trial is to assess the safety and performance of the everolimus-eluting Evolution stent for the treatment of a de novo atherosclerotic lesion of up to 28 mm in length in a native coronary artery 2.25 mm…
- Trial name
- Evolve (NCT01135225)
- Testing
- PROMUS(TM) Element (TM) Stent System, Evolution Stent System
- Where
- 29 sites in Australia, Belgium and 7 more
- Volunteers
- 291 people
- Sponsor
- Boston Scientific Corporation
Stent Thrombosis
Factors Contribute to Very Late Stent Thrombosis After New Generation DES Implantation in China
The investigators sought to identify and verify the potential correlates and mechanisms of Very Late Stent Thrombosis (VLST) after the implantation of new generation drug eluting steng in China from an analysis of multicenter…
- Trial name
- NCT03491891
- Where
- China
- Volunteers
- 8,476 people
- Sponsor
- The First Hospital of Jilin University
Aortic Stenosis, Symptomatic Aortic Stenosis
China S3: Safety and Effectiveness of Edwards Lifesciences SAPIEN 3 THV in the Chinese Population
To evaluate the safety and effectiveness of the SAPIEN 3 (Edwards Lifesciences, Irvine, California) transcatheter heart valve implantation (TAVI) in Chinese patients with symptomatic severe calcific aortic stenosis who are…
- Conditions
- Aortic Stenosis, Symptomatic Aortic Stenosis, Aortic Regurgitation
- Trial name
- NCT03466918
- Testing
- SAPIEN 3 THV with the Commander delivery system
- Where
- 4 sites in China
- Volunteers
- 58 people
- Sponsor
- Edwards Lifesciences
Hearing Loss
Ponto Implantation Using a Minimally Invasive Surgical Technique
This multi-centre study funded by Oticon Medical AB will be conducted at seven hospitals across Europe (UK, Sweden, Denmark and the Netherlands).
- Trial name
- NCT04606823
- Testing
- Minimally invasive surgery, Glasgow Benefit Inventory (GBI), Additional follow-up visits after surgery
- Where
- 7 sites in Denmark, Netherlands and 2 more
- Volunteers
- 52 people
- Sponsor
- Oticon Medical
Cataract, Presbyopia
A Randomised Evaluation of Visual Function After Bilateral Implantation of Two Types of Presbyopia-correcting IOLs
Since the introduction of intraocular lenses (IOL) in the treatment of cataract, the postoperative accommodative loss of the human eye has been a trending topic.
- Trial name
- NCT03117426
- Testing
- SYMFONY IOL, AT LISA tri 839MP IOL
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Tear; Knee, Cartilage, Articular
Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures
This is a phase III, randomised controlled trial of matrix-encapsulated chondrocyte implantation procedure compared to the microfracture procedure in the repair of symptomatic cartilage lesions of the knee.
- Trial name
- NCT01947374
- Testing
- Matrix encapsulated chondrocyte implantation, Microfracture awl
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Ischemic Stroke, Atrial Fibrillation
Single-stage Pulmonary Vein Isolation Combined With Percutaneous Left Atrial Appendage Occluder Implantation in Patients With Recent Onset Ischemic Stroke and Atrial Fibrillation
The project is a multicenter, open-label, randomized medical experiment, which was designed to evaluate the efficacy and safety of single-stage pulmonary vein isolation (PVI) and implantation of left atrial appendage occluder…
- Trial name
- PILOS-AF (NCT06212674)
- Testing
- PVI + LAAO, single stage, LAAO, NOAC
- Where
- 2 sites in Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Silesia
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