Clinical trials: EMBRYO IMPLANTATION
Mixed Urinary Incontinence
Implantation of an Adjustable Suburethral Sling is an Effective Treatment Method for Patients With Mixed Urinary Incontinence of Moderate to Severe Severity, After Which the Severity of the Stress and Urgency Components is Reduced.
The aim of this clinical study is to optimize treatment outcomes in patients with mixed forms of urinary incontinence by implanting an adjustable suburethral sling and to determine factors influencing treatment effectiveness.
- Trial name
- NCT07564323
- Testing
- implantation of an adjustable suburethral sling
- Volunteers
- 156 people
- Sponsor
- Saint Petersburg State University, Russia
Aortic Stenosis, Severe
Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic Valve Replacement
Transcatheter aortic valve implantation (TAVI) has evolved into a standard therapy for severe aortic stenosis across all surgical risk profiles, supported by pivotal trials in high- and low-risk populations.
- Trial name
- SELECT TAVR (NCT07689279)
- Testing
- Transcatheter Heart Valve
- Volunteers
- 604 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
T-Shaped Uterus, Infertility, Female
Investigation of U1-A Uterine Anomalies Implantation Markers From the Lateral Walls of the Endometrium
Various types and classes of uterine malformations have been identified and the ESHRE / ESGE classification system has recently been published on female genital system anomalies.
- Conditions
- T-Shaped Uterus, Infertility, Female, Genital Tract Anomalies
- Trial name
- NCT04501003
- Testing
- Bipolar cutting electrode (26040 BL1 Karl Storz, Tuttlingen)
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Patients Having Undergone Unilateral Cataract Extraction and Implantation of a Monofocal
OPEN-LABEL, MULTI-CENTER, PHASE 1b/2a CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND EFFICACY OF IONTOPHORETIC DEXAMETHASONE PHOSPHATE OPHTHALMIC SOLUTION IN PATIENTS HAVING UNDERGONE CATARACT SURGERY WITH IMPLANTATION OF A POSTERIOR CHAMBER INTRAOCULAR LENS (IOL)
To evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution, EGP-437®, using the EyeGate® II Drug Delivery System (EGDS) in patients having undergone cataract surgery with…
- Trial name
- NCT02571556
- Testing
- Experimental: Dexamethasone Phosphate Ophthalmic solution (40 mg/mL) delivered by ocular iontophoresis consisting of 4.0 mA-min at 1.5 mA
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Temporary Cardio-neural Pacing, Pacemaker Implantation
Cardioneural Temporary Pacing to Achieve Autonomic Modulation
Atrial fibrillation (AF) is the most common arrhythmia, with a lifetime risk of 1 in 3-5. In cases of rapid ventricular rate, patients often experience low blood pressure, making standard rate and rhythm control medications…
- Trial name
- NCT07247422
- Testing
- Temporary cardio-neural pacing
- Where
- Hong Kong
- Volunteers
- 33 people
- Sponsor
- Chinese University of Hong Kong
Drug-Interactions
Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation
The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting.
- Trial name
- EFA-1 (NCT00465322)
- Testing
- fluvastatin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease, Stable Angina
Optimal Predilatation Treatment Before Implantation of a Magmaris Bioresorbable Scaffold in Coronary Artery Stenosis
The aim of the study is to investigate if lesion preparation with a ScoreFlex balloon compared to a standard non-compliant balloon improve vascular healing and minimize lumen reduction after implantation of a Magmaris…
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Myocardial Infarction
- Trial name
- OPTIMIS (NCT04666584)
- Testing
- ScoreFlex balloon, Device: standard non-compliant balloon
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Odense University Hospital
Aortic Valve Stenosis
Comparison of Strategies for Vascular Access Closure After Transcatheter Aortic Valve Implantation
The ACCESS-TAVI trial is an investigator-initiated, prospective, randomized, multicenter, open-label clinical trial. The objective of the trial is to compare two different vascular closure device strategies for large bore…
- Trial name
- ACCESS-TAVI (NCT05503199)
- Testing
- Combination of one Perclose ProGlide or ProStyle (Abbott Vascular) and one Angio-Seal (Terumo)., Combination of two ProGlides or ProStyles (Abbott Vascular).
- Where
- Germany
- Volunteers
- 450 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cataract, Lens Opacity
Comparison of Clinical Outcomes POD L GF vs POD F GF (PHY1707)
Prospective, randomised, controlled, single-surgeon, single-center clinical study to compare the clinical outcomes of two trifocal IOLs differing in the dominance of additional power.
- Conditions
- Cataract, Lens Opacity, Presbyopia
- Trial name
- NCT03688399
- Testing
- IOL implantation experimental, IOL implantation comparator
- Where
- Hungary
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Infertility
GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT
Purpose:The aim of this project is to prospectively determine whether a single dose of GnRH-agonist administered at the time of implantation increases or not the reproductive outcome in patients undergoing in vitro fertilization…
- Trial name
- NCT03039049
- Testing
- Triptorelin 0.1 mg
- Where
- 2 sites in Algeria
- Volunteers
- 328 people
- Sponsor
- Centre Hospitalier Universitaire Ibn Rochd
Cataract
Spectacle Independence and Overall Satisfaction With AcrySof® Panoptix® Toric Intraocular Lens
The study was designed to assess the spectacle independence and satisfaction of patients receiving the AcrySof® Panoptix® Toric intraocular lens (IOL) after uneventful cataract surgery.
- Trial name
- NCT04128514
- Testing
- Panoptix Toric
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eye Center of North Florida
Infertility, Preimplantation Genetic Screening
Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
This is a single centre retrospective study in repeated implantation failure patients: < 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of…
- Trial name
- NCT03001648
- Testing
- PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacion Dexeus
Infertility, Female
Cytokine Profile of the Uterine Secretome After Therapeutic Endometrial Scratching
This study investigates the impact of endometrial scratching on endometrial secretion, when correlated to pregnancy.
- Trial name
- NCT03042364
- Testing
- Pipelle de Cornier
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
End-stage Heart Failure Awaiting VAD Implantation
COVADIS Pilot Trial: COseal in Ventricular Assist DevIceS
The objective of this controlled, non-randomized, single-center pilot study (CoSeal arm prospective)study is to evaluate the efficacy of the synthetic surgical hydrogel CoSeal® in the prevention of cardiac adhesion formation in…
- Trial name
- COVADIS (NCT01244321)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- German Heart Institute
Primary Open Angle Glaucoma and Cataracts
A Clinical Trial of Phacoemulsification Versus Phacoemulsification & the iStent Implantation in POAG Patients
This was a prospective, double-masked, 15-month clinical trial comparing efficacy of phacoemulsification alone to combined phacoemulsification and implantation of the iStent® trabecular micro-bypass stent in patients with primary…
- Trial name
- NCT00847158
- Testing
- phacoemulsification alone, iStent Trabecular Micro-Bypass Stent
- Volunteers
- 36 people
- Sponsor
- University of Turin, Italy
Coronary Artery Disease
Short-Term Exposure to Lipophilic Anti-proliferative Drugs Delivered by Angiographic Contrast Media
This was a randomized, placebo-controlled, multi-centre study, double-blind within each dose level, with four ascending dose levels to test the tolerability and safety of iopromide-paclitaxel in patients with de novo lesions in…
- Trial name
- NCT01140204
- Testing
- Implantation of a bare metal stent
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital, Saarland
Partial Edentulism Class 1, Dental Implantation
The Efficacy of Freehand, Pilot Drilled and Fully Guided Implant Surgery in Partially Edentulous Patients: a Randomize Control Trial
This study evaluates three different methods of dental implant surgery-freehand, pilot-drilled, and fully guided techniques-in patients with partial tooth loss (partial edentulism).
- Conditions
- Partial Edentulism Class 1, Dental Implantation, Osseointegration
- Trial name
- NCT06764784
- Testing
- Freehand Implant Surgery, Pilot-Drilled Implant Surgery, Fully Guided Implant Surgery
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Prostate Cancer
Positioning and Tracking the Prostate During External Beam Radiation
The purpose of this study is to evaluate a non-ionizing electromagnetic method to align the prostate treatment site for radiation therapy and to monitor its position throughout radiation therapy delivery.
- Trial name
- NCT00123838
- Testing
- Calypso® 4D Localization System
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- Varian, a Siemens Healthineers Company
Cataract, Lenses, Intraocular
Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL Implantation
The goal of this observational study is to assess the effect of intraocular lens (IOL) movement in patients who have undergone Clareon® Vivity® IOL implantation.
- Trial name
- NCT05827133
- Testing
- No intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- East Coast Institute for Research
Recurrent Implantation Failure, Infertility (IVF Patients)
Endometrial Immune Profile in Recurrent Implantation Failure
The goal of this observational study is to learn whether differences in the immune cells of the womb lining (endometrium) help explain why some women do not become pregnant despite several IVF attempts using good-quality embryos…
- Trial name
- NCT07848399
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- King's College London
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