Clinical trials: ESRD
Kidney Failure, Chronic, Renal Dialysis
Renal Denervation in End Stage Renal Disease Patients With Refractory Hypertension
The purpose of this this study is to investigate the clinical utility of renal denervation in the treatment of ESRD patients with refractory hypertension.
- Trial name
- NCT00753116
- Testing
- Renal Denervation with a catheter-based procedure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Vascular
Renal Insufficiency, Chronic
Safety and Efficacy of Zemplar Capsule in Reducing Serum iPTH Levels in Chronic Kidney Disease Subjects (Daily Dosing)
The objective of this study is to determine whether paricalcitol is safe and effective compared to placebo in reducing elevated serum PTH levels in patients with chronic kidney disease.
- Trial name
- NCT00048516
- Testing
- paricalcitol capsule
- Where
- 18 sites in United States, Poland
- Volunteers
- 68 people
- Sponsor
- Abbott
Machine Learning, Acute Kidney Injury
Machine Learning Predict Renal Replacement Therapy After Cardiac Surgery
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication which may result in adverse impact on short- and long-term mortality.
- Conditions
- Machine Learning, Acute Kidney Injury, Renal Replacement Therapy, Prediction Models
- Trial name
- NCT04977687
- Where
- China
- Volunteers
- 2,108 people
- Sponsor
- Chinese PLA General Hospital
Heart Failure, Chronic Kidney Diseases
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Several drugs have been labeled as guideline-directed-medical therapies (GDMT) to improve overall health outcomes and slow the progression of disease in patients with heart failure (HF).
- Trial name
- NCT05531214
- Testing
- Multidisciplinary Care Coordination Team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- George Washington University
Chronic Renal Disease
Nephrotoxicity of Iopamidol Versus Iodixanol in High-Risk Patients
The purpose of this study is to compare the incidence of contrast-induced nephropathy (CIN) following the administration of iopamidol-370 (Iopamiro-370) and iodixanol-320 (Visipaque 320) in patients with chronic kidney disease…
- Trial name
- NEIHR (NCT01402219)
- Testing
- Iopamidol injection 76%, iodixanol
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Guangdong Provincial People's Hospital
Myeloma Multiple
Testing the Investigational Agent Combination of Daratumumab, Bortezomib, and Dexamethasone Compared to the Usual Treatment of Cyclophosphamide, Bortezomib, and Dexamethasone in Newly Diagnosed Multiple Myeloma Patients With Kidney Failure
This study is being done to answer the following question: Can the addition of daratumumab-hyaluronidase to the usual treatment of bortezomib and dexamethasone improve kidney function in patients who are newly diagnosed with…
- Trial name
- NCT07085728
- Testing
- Cyclophosphamide, Bortezomib (VELCADE), Dexamethasone
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Eastern Cooperative Oncology Group
Cardiovascular Diseases, Heart Diseases
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Kidney Failure, Chronic
- Trial name
- NCT00005536
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Kidney Injury, Acute Renal Failure
A Comparison of Dilute Versus Concentrated Heparin for CRRT Anticoagulation
Heparin is commonly used for anticoagulation of the extracorporeal circuit during continuous renal replacement therapy (CRRT) but the optimal mode of delivery has not yet been validated.
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Heart Failure
- Trial name
- NCT01318811
- Testing
- Dilute unfractionated heparin, Standard concentration unfractionated heparin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Hypotension, ENT Disease
Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery
The aim of the project is to investigate whether the use of the HPI can reduce the number and duration of intra- and postoperative hypotension in ventilated patients during and two hours after extensive surgery in the head and…
- Conditions
- Hypotension, ENT Disease, Acute Kidney Injury, Anesthesia
- Trial name
- NCT04151264
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Giessen
Chronic Kidney Disease, Type 2 Diabetes
Autologous Neo-Kidney Augment (NKA) in Patients With Type 2 Diabetes and Chronic Kidney Disease (CKD)
A Phase II, Open-Label Safety and Efficacy Study of an Autologous Neo-Kidney Augment (NKA) in Patients With Type 2 Diabetes and Chronic Kidney Disease (RMTX-CL001).
- Trial name
- RMCL-CL001 (NCT02525263)
- Testing
- Neo-Kidney Augment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Prokidney
Renal Impairment
A Study of Inclisiran in Participants With Renal Impairment Compared to Participants With Normal Renal Function (ORION-7)
This study is a Phase I, single-dose, open-label trial to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of a single dose of inclisiran subcutaneous (SC) injection in participants with mild…
- Trial name
- NCT03159416
- Testing
- Inclisiran
- Where
- 2 sites in New Zealand
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Antibiotic Toxicity, Liver Cirrhosis
A Study to Determine Pharmacokinetic Changes of Ceftriaxone in Patients With Liver Cirrhosis
The investigators designed an observational multicenter explorative in vivo study to investigate the changes in ceftriaxone pharmacokinetics in blood and ascites.
- Conditions
- Antibiotic Toxicity, Liver Cirrhosis, Renal Insufficiency, Ceftriaxone Overdose
- Trial name
- TACTILE (NCT05960006)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Morality, Acute Kidney Injury
Perioperative Outcome Risk Assessment With Computer Learning Enhancement
This study will test whether anesthesiology clinicians working in a telemedicine setting can predict patient risk for postoperative complications (death and acute kidney injury) more accurately with access to a machine learning…
- Trial name
- ORACLE (NCT05042804)
- Testing
- Machine learning models predicting postoperative death and acute kidney injury
- Where
- United States
- Volunteers
- 5,114 people
- Sponsor
- Washington University School of Medicine
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Dyslipidemia
Trial to Evaluate the Efficacy of Fluvastatin on Certain Markers
To analyze efficacy of fluvastatin on patients with chronic renal disease by analyzing certain inflammatory markers. In addition, tolerability and safety will also be evaluated in a Spanish population.
- Trial name
- NCT00171262
- Testing
- Fluvastatin
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Novartis
Acute Kidney Injury
Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass
The main objective of this study is to evaluate the efficacy of intravenous sodium nitrite compared with placebo in reducing the occurrence of CSA-AK as diagnosed by KDIGO criteria during the first 72 hrs after cardiac surgery in…
- Trial name
- NCT03331146
- Testing
- Saline, Sodium Nitrite
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Kidney Disease, Sarcopenia
Sarcopenia in Chronic Kidney Disease (CKD) Patients
Sarcopenia, or loss of muscle and strength is common in patients with poor kidney function. Although a high protein diet is generally recommended for sarcopenia, patients with poor kidney function are advised to follow a…
- Trial name
- BOOST_CKD (NCT07437053)
- Testing
- Valine, EEA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Peritonitis
Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients During Acute Peritonitis
The objective of the present study is to evaluate the a prior hypothesis that treatment with icodextrin during acute peritonitis would improve the treatment outcomes of peritonitis complicating peritoneal dialysis.
- Trial name
- NCT01044446
- Testing
- Icodextrin, glucose-based peritoneal dialysate
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong