Clinical trials: EUS
Biliary Obstruction
Feasibility of EUS-guided Biliary Drainage With LAMS for the Treatmentof Patients With Distal Malignant Biliary Obstruction
Distal malignant biliary obstruction results from different types of tumors including pancreatic cancer, biliary tract cancer (BTC), gallbladder cancer, and metastasis, which can lead to obstructive jaundice.
- Trial name
- SPAXUS (NCT04723199)
- Testing
- Electrocautetery LAMS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Clinico Humanitas
Sedoanalgesia
Effects of Preoperative Anxiety and Pain Sensitivity in Cases of Endoscopic Ultrasonography Received Sedoanalgesia
The objective of this study was to detect whether preoperative anxiety and pain sensitivity had effects on the consumption of anesthetics, time to achieve desired level of sedation, patient and endoscopist satisfaction, and…
- Trial name
- NCT03114735
- Volunteers
- 80 people
- Sponsor
- Istanbul Medeniyet University
Chronic Liver Disease
19Gauge Fine Needle Biopsy (FNB) Versus 22Gauge FNB for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB)
To determine the adequacy of EUS-LB using a 19G core needle compared to a 22G core needle in a prospective randomized study.
- Trial name
- NCT04806607
- Testing
- 19G FNB, 22G FNB
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Geisinger Clinic
Lung Cancer
Surgical Versus Non-surgical Staging of Lung Cancer
About half of all lung cancers are caught after they have spread to nearby lymph nodes. Lymph nodes are small glands found throughout the body that remove bacteria and foreign particles (part of the immune system).
- Trial name
- NCT01117714
- Testing
- Integrated Staging for Early Detection of Metastases in Lung Cancer
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Pancreatic Diseases
First-in-human Integrated Endoscopic Ultrasound (EUS) Navigation System Clinical Study
The complexity of the medical expertise required for endoscopic manipulation and image interpretation complicates the implementation of echo-endoscopy (or EUS for "Endoscopic Ultrasound").
- Trial name
- EZ-EUS1 (NCT06798545)
- Testing
- endoscopic ultrasound with navigation system
- Where
- France
- Volunteers
- 64 people
- Sponsor
- IHU Strasbourg
Biliary Intervention, Altered Anatomy
EUS-directed Transenteric ERCP (EDEE) in Patients With Benign and Malignant Underlying Conditions and Inaccessible Papilla/Biliodigestive Anastomosis (BDA)
Safety and efficacy of EDEE (EUS-directed transenteric ERCP)
- Conditions
- Biliary Intervention, Altered Anatomy, Malignant Gastric Outlet Obstruction, EUS Guided Enteroenteric Anastomosis
- Trial name
- NCT07096895
- Testing
- EDEE (EUS-directed transenteric ERCP)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Evangelisches Krankenhaus Düsseldorf
Celiac Ganglia
Identification of Celiac Ganglia
Computer-aided image recognition will improve the technique of endoscopic ultrasound-celiac plexus block/celiac plexus neurolysis (EUS-CPB/CPN) and improved pain relief.
- Trial name
- NCT01010360
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pancreas Adenocarcinoma
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer
This study is for the verification of biomarkers for pancreatic cancer treatment using small RNA liquid biopsy, combined with EUS-FNA tissues.
- Trial name
- NCT04636788
- Testing
- Venous sampling
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Klatskin Tumor, Cholangiocarcinoma
Diagnostic Efficacy of EUS-FNA/B Versus ERCP With or Without POCS-TB in Patients With Suspected Hilar Cholangiocarcinoma
This is an observational study with a prospective cohort design. This study enrolled patients with suspected hilar cholangiocarcinoma on imaging.
- Conditions
- Klatskin Tumor, Cholangiocarcinoma, Biopsy, Fine-Needle, Endoscopic Retrograde Cholangiopancreatography
- Trial name
- NCT05993429
- Testing
- The sampling method selected in patients with suspected hilar cholangiocarcinoma
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qilu Hospital of Shandong University
Cognitive Impairment
Assessment of Cognitive and Functional Impairment in Older Patients After ERCP
Endoscopic retrograde cholangiopancreatography (ERCP) is an interventional endoscopy procedure utilized in the therapeutic management of pancreatobiliary diseases including gallstones, bile duct strictures, leaks and infections…
- Trial name
- NCT03762954
- Testing
- Neurocognitive function assessment
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Vanderbilt University Medical Center
Solid Pancreatic Masses
Endoscopic Ultrasound-guided Fine Needle Biopsy With 25-gauge Biopsy Needles for Solid Pancreatic Masses
For 12 months after approvement by the University of Yonsei institutional review board, of the 59 patients older than 20 years referred to our medical center for EUS-FNA or FNB, all consecutive pancreatic lesions were evaluated…
- Trial name
- NCT01795066
- Testing
- EUS-FNB with 25-gauge (Echotip ProCore; Cook Endoscopy Inc, Limerick, Ireland)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Solid Pseudopapillary Tumor
Safety of EUS-FNA for Pancreatic Solid-Pseudopapillary Neoplasm (SPN) Before Surgical Resection: the SPN-GRAPHE Series
Solid-pseudopapillary neoplasm (SPN) is a rare type of pancreatic neoplasm. A cytopathological diagnosis is often mandatory before performing surgical resection.
- Trial name
- SPN-GRAPHE (NCT03749941)
- Volunteers
- 149 people
- Sponsor
- Société Française d'Endoscopie Digestive
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Patient Registry in Patients Undergoing Contrast-Enhanced Harmonic Endoscopic Ultrasound Imaging
This study creates a patient registry of patients undergoing contrast-enhances-harmonic endoscopic ultrasound imaging. In order to improve what doctors see on the ultrasound exam, sometimes intravenous contrast can be used to…
- Trial name
- NCT05717101
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Biopsy, Fine-needle, Pancreatic Neoplasm
EUS-FNB With ROSE Vs. EUS-FNB Without ROSE
Rationale: Rapid on-Site Evaluation (ROSE) of cytologic specimens acquired with EUS-guided fine needle aspiration (EUS-FNA) represents the most accurate available technique to reach a definitive diagnosis in patients with…
- Trial name
- FROSENOR (NCT03322592)
- Testing
- Rapid on-site evaluation (ROSE), Histologic evaluation
- Where
- 13 sites in United States, Australia and 6 more
- Volunteers
- 800 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Anxiety, Pancreatic Cancer
Graphic Novel for Patients Undergoing EUS-FNB
Endoscopy with endoscopic ultrasound (EUS) is a primary technique for diagnosing and treating severe pancreatic disorders. However, the procedure can cause fear and anxiety in patients, especially when a biopsy is involved.
- Conditions
- Anxiety, Pancreatic Cancer, Pancreatic Cystic Lesions, Stress
- Trial name
- NCT06268106
- Testing
- Graphic novel visualization
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Pancreatic Adenocarcinoma
Gene Therapy of Pancreatic Ductal Adenocarcinoma
Near 85% of patients with pancreatic adenocarcinoma are diagnosed with a locally advanced and/or metastatic unresectable tumor. In these patients chemotherapy (such as gemcitabine) is given as a palliative therapy.
- Trial name
- TherGAP (NCT01274455)
- Testing
- Gene Therapy product CYL-02 = plasmid DNA pre-complexed to linear polyethylenimine encoding sst2 + dck::umk genes
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Gastric Outlet Obstruction
Randomized Trial of EUS-guided Gastrojejunostomy and Surgical Gastrojejunostomy in Gastric Outlet Obstruction
Malignant gastric outlet obstruction (GOO) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer.
- Trial name
- NCT05548114
- Testing
- EUS-guided gastrojejunostomy, Surgical gastrojejunostomy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Orlando Health, Inc.
Endoscopic Ultrasonography, EUS-FNA
Heparin-based Wet Suction Method in EUS Fine Needle Biopsy of Solid Pancreatic Mass
The objective of this randomized cross-over trial is to evaluate whether Heparin based wet suction technique, compared with dry suction technique, shall present a higher quality tissue core by using quantitative macroscopic and…
- Conditions
- Endoscopic Ultrasonography, EUS-FNA, Pancreatic Neoplasms
- Trial name
- NCT04707560
- Testing
- EUS fine needle biopsy with heparin wet suction
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng-Kung University Hospital
Malignancy, Pain Management
Endoscopic Ultrasound Guided Coeliac Plexus Neurolysis for Cancer Pain
Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive…
- Trial name
- NCT04801082
- Testing
- Alcohol injection, Radiofrequency Ablation
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Pancreatic Adenocarcinoma Non-resectable
EUS-RFA for Unresectable Pancreatic Ductal Adenocarcinoma
the study evaluate the efficacy and safety of EUS-RFA using Habib EUS-RFA catheter with a prospective randomised trial in patients with inoperable PDAC.
- Trial name
- NCT03772756
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, chemoradiotherapy
- Where
- 2 sites in China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou