Clinical trials: EUS
Biliary Strictures
Endoscopic Ultrasound-guided Fine-needle Biopsy for Tissue Sampling of Biliary Strictures: a Multicenter Prospective Study
After the disappointing results of first-generation reverse bevel fine-needle biopsy (FNB) needles, newer 'third generation' endoscopic ultrasound (EUS) needles were developed, known as the "end-cutting" needles.
- Trial name
- NCT06614452
- Testing
- EUS-FNB
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Ospedali Riuniti di Foggia
Bile Duct Diseases
The Role of Endoscopic Ultrasound in Evaluation of Patients With Indefinite Cause of Bile Duct Dilatation
In the era of diagnostic imaging advances, Bile Duct Dilatation becomes a common incidental finding in patients present with either gastrointestinal symptoms or undergone the imaging study for any other complaints.
- Trial name
- NCT05475964
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HMHamed
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage
Prospective multi-site study of ultrasound-guided percutaneous biliary drainage and endoscopic ultrasound-guided biliary drainage with implantation of a self-expanding metal stent in patients with malignant, distal bile duct…
- Trial name
- PUMa (NCT03546049)
- Testing
- US-guided percutaneous biliary drainage, EUS-guided biliary drainage
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Pancreatitis, Acute, EUS Guided Biopsy
EUS-guided FNB-induced PANCREatitis Assessment
This is a descriptive analytical study to investigate the prevalence and risk factors for pancreatitis after Endoscopic Ultrasonography-guided Fine Needle Biopsy (EUS-FNB) in patients at Shariati Hospital in Tehran.
- Trial name
- EUS-PANCREA (NCT07168863)
- Testing
- EUS-guided FNB
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- University of Tehran
Gastric Outlet Obstruction
EUS - Guided Balloon-occluded Gastrojejunostomy Bypass
Surgical gastrojejunostomy is the conventional treatment for palliating patients suffering from of inoperable malignant gastric outlet obstruction (GOO).
- Trial name
- NCT03223480
- Testing
- EUS-guided gastrojejunstomy
- Where
- Hong Kong
- Volunteers
- 14 people
- Sponsor
- Chinese University of Hong Kong
Cirrhosis, Portal Hypertension
EUS-PPG vs HVPG in Portal Hypertension
The objective of this study is to evaluate the correlation of the calculated portal pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with a conventional 22 G needle guided by EUS and indirect…
- Trial name
- GRAPE (NCT05689268)
- Testing
- EUS-PPG and HVPG
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Hospital General Universitario de Alicante
Malignant Gastric Outlet Obstruction
Comparing Endoscopic Ultrasound vs Surgical Gastrojejunostomy for Management of GOO.
The goal of this interventional study is to learn about the outcomes between two options for the management of malignant gastric outlet obstruction.
- Trial name
- RESTORE (NCT06128018)
- Testing
- Surgical gastrojejunostomy (S-GJ), EUS-guided gastrojejunostomy (EUS-GJ)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- AdventHealth
Pancreatic Mass, Peripancreatic Mass
Endoscopic Ultrasound-guided Fine Needle Aspiration of Solid Masses: Histological and Immunohistochemical Evaluation
The aim of this retrospective single center study was to evaluate the clinical utility of histological and immunohistochemical analyses of specimens obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA).
- Trial name
- NCT01437410
- Testing
- EUS-FNA
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Samsung Medical Center
Pancreatic Cyst
Contrast Enhanced Ultrasound and Molecular Analysis in the Diagnosis of Pancreatic Cyst
This study evaluates the use of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) and cyst fluid molecular analysis in the differential diagnosis of pancreatic cysts and the detection of malignancy.
- Trial name
- NCT03740360
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Pancreatic Cancer
Pancreatic Core Biopsy Needle Study in Patients Suspected of Pancreatic Malignancy
This study evaluates whether a new endoscopic ultrasonography (EUS) histology needle may improve the diagnostic yield during biopsies of pancreatic lesions
- Trial name
- PANCOBE (NCT03016637)
- Testing
- SharkCore (TM) FNB Exchange System
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Pancreatic Cancer
Safety and Efficacy of Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA) in the Treatment of Pancreatic Lesions
This is a 7-year prospective single-center registry study to assess the safety and efficacy of Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA) in the treatment of pancreatic lesions.
- Trial name
- NCT07737171
- Testing
- Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute, Pancreatitis
Soluble Triggering Receptor Expressed on Myeloid Cells in Severe Acute Pancreatitis
Early diagnosis of secondary infection of necrotic tissue in severe acute pancreatitis is extremely important. The investigators evaluated whether the level of soluble TREM-1 (sTREM-1) in fine needle aspiration (FNA) fluid from…
- Trial name
- STREM-1 (NCT01193413)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Malignant Biliary Obstruction, Advanced Pancreatic Cancer and Cholangiocarcinoma
Improving a Bile Duct Drainage Procedure in Patients With Inoperable Cancer Blocking the Bile Ducts: Comparing Two Types of Endoscopically Placed Internal Stents to Prevent Blockage of a Lumen Apposing Metal Stent
This study looks at the best way to treat bile duct blockage in people with advanced cancer that cannot be removed by surgery. A blocked bile duct can cause serious symptoms like yellowing of the skin (jaundice), infection, and…
- Conditions
- Malignant Biliary Obstruction, Advanced Pancreatic Cancer and Cholangiocarcinoma, Inoperable Malignant Biliary Obstruction, Lumen Apposing Metal Stents
- Trial name
- Opti-LAMS (NCT07115420)
- Testing
- Fully covered self expanding metal stent (FCSEMS) within LAMS, Double pigtail stent (DPS) within LAMS
- Where
- New Zealand
- Volunteers
- 100 people
- Sponsor
- Waikato Hospital
Malignant Biliary Obstruction
EUS-Guided Choledochoduodenostomy Versus ERCP for Primary Biliary Decompression in Distal Malignant Biliary Obstruction
Malignant biliary obstruction commonly caused by pancreatic adenocarcinoma, cholangiocarcinoma and other etiologies like gallbladder carcinoma, hepatocellular carcinoma, lymphoma, and metastasis to regional solid organs and lymph…
- Trial name
- NCT04898777
- Testing
- Biliary drainage
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Pancreas Cyst
DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas
Diagnostic tools are needed to identify mucinous cysts for further evaluation or follow-up respectively to identify cysts with HGD or invasive cancer at an early stage for surgical resection.
- Trial name
- NCT03820531
- Testing
- Next Generation Sequencing, CEA and lipase, Cytology
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Jaundice
Prospective Randomized Study of PTC and EUS-guided Drainage of the Bile Duct
At this time, endoscopic retrograde cholangiopancreatography (ERCP) stay the gold standard method to achieve biliary drainage in case of malignant or benign stricture.
- Trial name
- NCT01499537
- Testing
- biliary drainage, EUS guided biliary drainage
- Where
- 3 sites in France, Monaco
- Volunteers
- 65 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Cancer, EUS-FNB
Profiling the Intratumoral Microbiome of Pancreatic Ductal Adenocarcinoma Based on EUS-FNB Tissue Samples and Exploring Its Impact on Tumor Diagnosis and Prognosis.
The goal of this observational study is to use endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) to investigate the intratumoral microbiome profile in patients with pancreatic ductal adenocarcinoma (PDAC) and to evaluate…
- Conditions
- Pancreatic Cancer, EUS-FNB, Intratumoral Microbiota, Diagnosis
- Trial name
- NCT06655233
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Pancreatic Cyst
EUS-guided Ablation of Pancreatic Cyst Neoplasms
This is a registry that will maintain prospective data on the clinical outcomes of all patients with pancreatic cyst lesions who undergo EUS-guided alcohol ablation.
- Trial name
- NCT02422147
- Testing
- Ablation of PCL
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- AdventHealth
Pancreatic Neoplasms
Comparison Between Olympus EZ Shot 3Plus 19G and EZ Shot 2 19G in EUS-guided FNB of Solid Pancreatic Masses
Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is a valid and recommended technique for tissue diagnosis of pancreatic masses.
- Trial name
- NCT02909530
- Testing
- EUS-FNB with EZ Shot 3Plus first, EUS-FNB with EZ Shot 2 19G first
- Where
- 4 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University of Ulm
Gastric Varices Bleeding, Gastric Varices
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix.
- Conditions
- Gastric Varices Bleeding, Gastric Varices, Portal Hypertension
- Trial name
- CoAGS-GV (NCT07699354)
- Testing
- EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol, EUS-Guided Coil Embolization With Absorbable Gelatin Sponge
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Unity Health Toronto