Clinical trials: Ear Infection
Chronic Serous Otitis Media, Simple or Unspecified
Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens
Rationale: Bacterial biofilms are defined as an assemblage of bacterial cells enclosed in a self-produced glycocalyx matrix. Adherence on surfaces, and resistance to both antibiotic treatments and host defenses are ones of the…
- Trial name
- BOLERO (NCT01022944)
- Testing
- With chronic middle ear effusion, Without chronic middle ear effusion
- Where
- France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infectious Diseases, Healthy Subjects
Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers
This single-center, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Infectious Diseases, Healthy Subjects, Respiratory Tract Infections, Sore Throat
- Trial name
- NCT01033799
- Testing
- Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), Non fermented dairy product (control)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Nasopharyngeal Colonization and Acute Otitis Media
Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children.
The purpose of this study is to Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children.
- Trial name
- AOM (NCT02591563)
- Testing
- procedures
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Rochester General Hospital
Otitis Media
Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients
The purpose of this study is to evaluate the use of intranasal dexmedetomidine to reduce the incidence of emergence delirium during general sevoflurane anesthesia in a pediatric population receiving pressure equalization tubes in…
- Trial name
- PED-DEX (NCT00778063)
- Testing
- dexmedetomidine, saline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Infections, Streptococcal
A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants
The primary aim of the study is to demonstrate that an investigational 4-dose presentation of the 10Pn-PD-DiT vaccine with preservative is non-inferior to the licensed presentation of Synflorix (preservative-free) in terms of…
- Trial name
- NCT02447432
- Testing
- Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (4-dose presentation), Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (1-dose presentation), DTPw-HBV/Hib
- Where
- Bangladesh
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Recurrent Acute Otitis Media, Acute Otitis Media
Efficacy of the EarPopper Device in Children With Recurrent Otitis Media
This is a randomized controlled clinical trial evaluating the efficacy of the EarPopper device (EP) in the reduction of episodes of acute otitis media (AOM) in children with recurrent otitis media.
- Trial name
- NCT03534219
- Testing
- EarPopper
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Pneumonia, Meningitis
Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea
The National Health Plan 2001-2010 calls for investigation of the feasibility of pneumococcal vaccines for Papau New Guinea. The Papua New Guinea (PNG) Institute of Medical Research, the Telethon Institute for Child Health…
- Conditions
- Pneumonia, Meningitis, Otitis Media
- Trial name
- NCT00219401
- Testing
- Pneumococcal 7 valent conjugate vaccine (Prevenar®)
- Where
- Papua New Guinea
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Otitis Media With Effusion
A Novel Objective Diagnostic Test for Otitis Media With Effusion
Otitis media with effusion (OME) cases refer to a clinically silent condition. Otoscopic findings are subjective and not always reliable. As an objective test tympanometric evaluation is imperfect for diagnosis of OME.
- Trial name
- NCT02179541
- Testing
- RGB
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Nazan Degirmenci
Acute Respiratory Tract Infection, Otitis Media
Broad Implementation of Outpatient Stewardship
Reducing inappropriate antibiotic use is a key strategy to mitigate antibiotic resistance and adverse health effects associated with antibiotic exposure.
- Conditions
- Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
- Trial name
- BIOS (NCT05127161)
- Testing
- Broad Implementation of Outpatient Stewardship (BIOS) intervention
- Where
- 5 sites in United States
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Tympanic Membrane Perforation
Insulin Intratympanic Application
The objective of the present study was to study the impact of insulin insitu-gel formulation on healing progress after surgical procedures for treatment of dry tympanic membrane perforation for at least three consecutive months.
- Trial name
- NCT07535827
- Testing
- Insulin (Humulin), foam
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deraya University
Hearing Loss, Bilateral or Unilateral, Otitis Media With Effusion in Children
Towards Implementation of Universal Newborn Hearing Screening in Kenya
The goal of this observational study is to learn if smartphone hearing screening devices can help to understand the role of ear infections in hearing loss in infants with HIV exposure.
- Trial name
- mTUNE-R33 (NCT07879326)
- Testing
- Hearing and ear health screening
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Pulmonary Diseases, Tonsillar Hypertrophy
The Influence of Feeding Position on Pulmonary Morbidity in Young Children
Supine feeding position is associated with serous otitis media. The hypothesis is that supine feeding is associated with recurrent otitis media, tonsillar and adenoid hypertrophy and recurrent pneumonia secondary to recurrent…
- Conditions
- Pulmonary Diseases, Tonsillar Hypertrophy, Otitis Media, Dental Caries
- Trial name
- NCT00248391
- Testing
- upright feeding
- Where
- Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
to Improve the Effectiveness of a Amino Acid Dietary Supplement in Chronic Pharyngeal Infections vs Placebo
Amino Acid Composition Reduces Frequency of Common Cold. Results of a Controlled Completely Masked Trial
The purpose of this study is to investigate the effectiveness of a dietary supplement with high dosage of amino acids and vitamins in the treatment of acute and chronic infection of pharyngeal area known as common cold. T
- Trial name
- NCT01414335
- Testing
- amino acid composition
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Kyberg Vital GmbH
Middle Ear Infection
Spectroscopic Evaluation of Middle Ear Infection
Otitis media is more common in young children and it is estimated that 75% of all children experience at least one episode before the age of three.
- Trial name
- NCT04812093
- Testing
- Spectroscopic otoscope measurements
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Acute Otitis Media, Allergic Rhinitis
A Trial of Point of Care Information in Ambulatory Pediatrics
Does presentation of clinical evidence for decision making at point-of-care improve prescribing patterns in ambulatory pediatrics?
- Conditions
- Acute Otitis Media, Allergic Rhinitis, Sinusitis, Constipation
- Trial name
- NCT00368823
- Testing
- Electronic point-of-care delivery system
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infections, Streptococcal
Healthcare Seeking Behaviour of Primary Caregivers for Acute Otitis Media (AOM) in Children Aged 6 Months to Less Than 30 Months in Panama
The study is a survey aiming to describe the healthcare seeking behaviour of primary caregivers when their child aged 6 months to less than 30 months was suspected to have an episode of acute otitis media in Panama.
- Trial name
- NCT01793857
- Testing
- Data collection
- Where
- 13 sites in Panama
- Volunteers
- 1,330 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Suppurative Otitis Media
Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
Objective To observe the safety and tolerability of Pazufloxacin Mesylate Ear Drops of different concentrations in patients with simple chronic suppurative otitis media.
- Trial name
- NCT03675841
- Testing
- Pazufloxacin Mesilate ear drops
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Streptococcus Pneumoniae, Nasopharyngeal Carriage
Carriage of Streptococcus Pneumoniae in Infants With Acute Otitis Media and in Infants Attending Day-care Centers
Rationale In Belgium, a unique situation exists for two reasons: on the one hand, the pneumococcal conjugate vaccine (PCV) program, which started in 2007, has quickly reached high coverage in infants: 3-dose coverage rose from 89…
- Trial name
- NCT02888457
- Testing
- Nasopharyngeal sampling with a swab
- Where
- Belgium
- Volunteers
- 2,817 people, healthy volunteers welcome
- Sponsor
- Pierre Van Damme
Otitis Media
Vaccination for Middle Ear Infection
Acute otitis media (OM) and OM with effusion are common childhood diseases. Otitis media is a condition marked by inflammation of the middle ear.
- Trial name
- NCT00001605
- Testing
- Nontypeable Haemophilus influenzae
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)