Clinical trials: Early Childhood
Anthracycline Induced Cardiotoxicity
Late Anthracycline Induced Cardiotoxicity- Childhood Cancer Survivors
Anthracyclines treat up to 60% of childhood malignancies with remarkable improvements survival rates. Unfortunately anthracyclines are associated with an increased cardiomyopathy risk.
- Trial name
- NCT04852965
- Where
- United Kingdom
- Volunteers
- 103 people
- Sponsor
- Queen's University, Belfast
Early Childhood Caries (ECC)
Caries Risk in Children Treated Under General Anesthesia for Early Childhood Caries
This observational, cross-sectional study aims to evaluate the current caries risk profiles of children who underwent dental treatment under general anesthesia (GA) for early childhood caries (ECC) between 2015 and 2020 at Aydın…
- Trial name
- NCT07330570
- Testing
- Caries Risk Assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Early Childhood Caries
Povidone Iodine Efficacy Study
This is a single center, randomized, double-blind, placebo-controlled Phase II clinical trial (RCT) to evaluate the efficacy of topical 10% Polyvinylpyrrolidone-Iodine (PVPI) to prevent new caries lesions when applied to the…
- Trial name
- PIES (NCT05272254)
- Testing
- 10% povidone iodine + FV
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Child Development, Adaptive Behavior
Effects of Music and Storytelling on Linguistic, Socioemotional, and Adaptive Development in Children Aged 12-36 Months: an Intervention Protocol in Municipal Early Childhood Centers
This randomized clinical trial aims to evaluate the impact of a structured enriched environment on the linguistic, adaptive behavior, and socioemotional development of children aged 12 to 36 months.
- Conditions
- Child Development, Adaptive Behavior, Early Child Development, Music Education
- Trial name
- MUS-STORY (NCT06831851)
- Testing
- Storytelling Sessions, Music Education Sessions, Parental Guidance Sessions
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Early Childhood Professional Development
Study of Coaching Practices in Early Care and Education Settings
Mathematica Policy Research, funded by the Administration for Children and Families (ACF) in the U.S. Department of Health and Human Services (HHS) will collect descriptive information for the Study of Coaching Practices in Early…
- Trial name
- SCOPE (NCT03743337)
- Where
- United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Mathematica Policy Research, Inc.
Dental Caries
Educational Intervention in Preventing Early Childhood Caries
Objective: The aim of this study is to assess the effectiveness of an oral health educative intervention in preventing early childhood caries (ECC).
- Trial name
- NCT01502566
- Testing
- Education Intervention
- Where
- Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Early Childhood Caries (ECC)
Goal Attainment-Based Parent Education for ECC Prevention
Preventing early childhood caries (ECC) requires improving parental knowledge and behavior, as parents play a critical role in establishing oral and dental health practices during early childhood.
- Trial name
- GAT-ECC (NCT07460271)
- Testing
- Structured Parent Education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Child Obesity
Improving Parent-Child Interactions to Enhance Child Health
Childhood obesity is a formidable public health issue in the United States, disproportionately affecting children from lower socioeconomic status households.
- Trial name
- PCIT-Health (NCT03982511)
- Testing
- PCIT-Health
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Michigan University
Lung Cancer
Outcome Measures in Infant/Early Childhood Lung Disease w/ Chest CT Scanning & Lung Function Testing
To implement a new method of performing chest CT imaging in young children at Packard Children's Hospital entitled controlled ventilation infant/young child chest CT scanning.
- Trial name
- NCT01158495
- Testing
- Intubation with a cuffed ET Tube, CT scan Radiation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Extrahepatic Portal Vein Obstruction (EHPVO)
Radiological Intervention for Childhood Extra-Hepatic Portal Vein Obstruction
This study evaluates the safety and effectiveness of percutaneous portal vein recanalization (PVR) with stent placement, with or without transjugular intrahepatic portosystemic shunt (TIPS), in restoring portal flow and improving…
- Trial name
- NCT07867587
- Testing
- Portal Vein Recanalization and Stenting
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Ain Shams University
Cerebral Palsy
Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy
This study assesses two active treatments in different sequences and a standard of care group among infants with cerebral palsy.
- Trial name
- APPLES-TELE (NCT04997109)
- Testing
- APPLES-tele, Parent-centered Approach (PCA) Support Intervention, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 267 people
- Sponsor
- Emory University
Skeletal Disorder
Bone and Muscle Health in Kids
Vitamin D deficiency in childhood leads to poor bone growth and muscle weakness, yet it is unknown if the amount of vitamin D a woman consumes during her pregnancy affects her child's bone and muscle development.
- Trial name
- BONUSKids (NCT03537443)
- Testing
- Cholecalciferol (vitamin D3)
- Where
- Bangladesh
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Early Childhood Caries
Happy Teeth for Hopi Tots: Cultural Adaptation of an Oral Health Entertainment-Education Intervention
Tooth decay is a preventable disease occurring at high rates among American Indian (AI) populations. The use of entertaining educational materials and cultural adaptation have shown success in improving health behaviors.
- Trial name
- NCT05297526
- Testing
- Culturally adapted children's book, Standard informational brochure on children's oral health
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northern Arizona University
Early Childhood Caries
Clinical Analysis of a Risk-graded and Comprehensive Intervention for Early-childhood-caries
Cariogram and Cariostat will be used to assess the risk of caries in kindergarten children aged 3 years. Routine preventive measures will be taken for children at low risk of caries, and intensive intervention measures will be…
- Trial name
- NCT05260216
- Testing
- Comprehensive prevention and treatment, Routine prevention
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Bowel Dysfunction, Hirschsprung Disease
Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease
Bowel dysfunction has been proven as the most common complication after pull-through(PT) of Hirschsprung disease(HD) ，which may persist to adulthood and lead to social problems.The reason of bowel dysfunction is complicated and…
- Conditions
- Bowel Dysfunction, Hirschsprung Disease, Risk Factor, Incontinence
- Trial name
- NCT05655845
- Testing
- bowel function score(BFS) questionnaire survey
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Weibing Tang
School Readiness, School Environment
Every Newborn Reach Up Early Education Intervention for All Children Education (ENREACH) Education
The goal of the project is to assess the scale-up of the program, focusing on improving school readiness among preschool children, enhancing capacity building for parents and teachers, and utilizing a cluster randomized…
- Trial name
- ENREACH-ED (NCT06890156)
- Testing
- ENREACH child-parent-teacher triad
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pediatric Obesity, Early Childhood Caries
Obesity and Caries in Young South Asian Children: A Common Risk Factor Approach
The CHALO ("Child Health Action to Lower Oral Caries and Obesity") -- from an Urdu word meaning "Let's go!"-is a multi-level strategy to reduce pediatric obesity and dental caries risk in South Asian (SA) children.
- Trial name
- CHALO (NCT03077425)
- Testing
- Enhanced Usual Care (EUC), Intervention
- Where
- 8 sites in United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine