Clinical trials: Early Detection of Cancer
Prostate Cancer, Cancer
Adaptation of the American Cancer Society (ACS) Early Detection of Prostate Cancer Patient Decision Aid for Spanish Speaking Men
Objectives: The primary objective of this project is to develop and evaluate a Spanish-language slide set for administration in group settings, adapted from the content of the current guidelines and existing, self-administered…
- Trial name
- NCT01447186
- Testing
- Post-Test Questionnaire, Interviews, Focus Groups
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Oropharyngeal Cancer
Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
Cancer of the oropharynx (middle, side and back walls of the throat; back of the tongue; soft palate, and tonsils), or oropharyngeal squamous cell carcinoma (OPSCC), has been on the rise in the United States.
- Trial name
- NCT02147418
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance
Pancreatic Cancer, Head and Neck Cancer
Creation of the BioBank, Early Detection and Discovery Biomarkers
To establish a multidisciplinary research structure for tissue repository that facilitates projects that bridge specialties that normally may or may not interact.
- Conditions
- Pancreatic Cancer, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT00901680
- Where
- United States
- Volunteers
- 3,028 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Breast Cancer
Medical Radiometer - RTM - 01 - RES and Its Use in Detecting Hotspots in Female Breast
Medical Radiometer depends on detecting the microwaves that radiates from deep structure hot objects in the body. When it comes to the breast, causes of deep structure hot spots are numerous, it can be inflammatory, hormonal or…
- Trial name
- RTM (NCT02286583)
- Testing
- Microwave Thermography RTM-01-RES
- Where
- Malaysia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Labdom Suisse
Cancer Screening
Multi-cancer Joint Screening and Early Diagnosis and Treatment Project Based on the Combination of Chinese Traditional and Western Medicine in Lanxi City
This study conducted a joint screening and early diagnosis and recommended treatment for LCA, LC, UGIC, and CRC among residents aged 45 to 74 in six townships of Lanxi City, Zhejiang Province.
- Trial name
- NCT06200051
- Testing
- Prediction of high risk of cancer
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lanxi Hospital of Traditional Chinese Medicine
Health Risk Behaviors
A Prospective Study for the Early Diagnosis of Lung Cancer in Korean Females
This is a single-arm prospective pilot study in a single institution. The target accrual is 200 participants of Korean, female sex, never smoker status, and family history of lung cancer.
- Trial name
- NCT06181929
- Testing
- Low dose CT
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sang-Won Um
Breast Cancer
Development of a Horizontal Data Integration Classifier for Noninvasive Early Diagnosis of Breast Cancer
This is a translational no-profit study. Our proposal aims at creating a noninvasive Horizontal Data Integration (HDI) classifier for early diagnosis of breast cancer, with the final goal of avoiding in most cases useless…
- Trial name
- RENOVATE (NCT04781062)
- Testing
- Blood and urine molecular analysis (Timing 0), Blood and urine molecular analysis (Timing 1)
- Where
- Italy
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Gastric Cancer
Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Gastric Cancer：MetBio-GC
This prospective clinical observational study aims to construct a metabolite database specifically for gastric cancer patients using metabolomics technology.
- Trial name
- NCT07076979
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Colorectal Cancer Screening, Advanced Adenomas (AA)
Validation of a Molecular Signature for Early Detection of Colorectal Cancer
The goal of this Multicentre and international prospective study is to validate a molecular signature using plasma samples in average-risk population for colorectal cancer who undergo colonoscopy in a screening setting.
- Trial name
- NCT06738511
- Testing
- blood sampling, stool sampling, colonoscopy
- Where
- 2 sites in Germany, Poland
- Volunteers
- 3,421 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Breast Cancer, Liquid Biopsy, Early Detection
Clinical Validation of Early Detection Blood Test for Universal Large-scale Breast Cancer Screening
Breast cancer is the most common cancer that spreads beyond the initial layer of tissue it developed in, and grows into surrounding healthy tissue in women worldwide. It is associated with significant illness and death.
- Trial name
- NCT07219277
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Syantra Inc.
Stomach Neoplasms, Circulating Tumor DNA
Methylation Analysis of Circulating Tumor DNA in Gastric Cancer
The primary purpose of this trial is to describe the profile of ctDNA methylation in gastric cancer. The second purpose is to demonstrate the correlation between the plasma ctDNA methylation status and the diagnosis and prognosis…
- Trial name
- NCT04511559
- Testing
- Circulating Tumor DNA Methylation Sequencing, tissue DNA Methylation Sequencing
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer
Research on Early Screening and Diagnosis of Pulmonary Nodules Based on Novel Non-invasive Technologies.
This is a prospective observational study designed to address the clinical challenge posed by the high false-positive rate associated with CT imaging in early lung cancer screening.
- Trial name
- NCT07370077
- Testing
- Employing multi-omics diagnostic approaches to enhance diagnostic efficacy
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Chen KeZhong
Brain Cancer, Breast Cancer
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types.
- Conditions
- Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- CAMPERR (NCT05366881)
- Where
- 17 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Adela, Inc
Gastric Cancer
Novel Screening Modality for Early Gastric Cancer
Potential patients will be recruited at participating sites based on routine care with clinical indications for upper endoscopy.
- Trial name
- NCT04114006
- Where
- Honduras
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Medical Oncology, Cancer
Ezra Faster Scan Study
The Ezra Faster Scan study uses non-invasive magnetic resonance imaging (MRI) technology that can "visually" detect early and late-stage cancer, and other pathologies.
- Conditions
- Medical Oncology, Cancer, Healthy
- Trial name
- FasterScan (NCT05385718)
- Testing
- Magnetic Resonance Imaging
- Where
- 5 sites in United States
- Volunteers
- 694 people, healthy volunteers welcome
- Sponsor
- Ezra AI, Inc.
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Chemotherapy Induced Cardiotoxicity
Cardiac Magnetic Resonance for Early Detection of Chemotherapy or Radiation Therapy Induced Cardiotoxicity in Breast Cancer (CareBest)
Chemotherapy or radiation therapy-induced cardiotoxicity are well-recognized side effects in patients with cancer. The clinical significance of cardiotoxicity is growing with increasing cancer survivor-ship.
- Trial name
- NCT03301389
- Testing
- Cardiac magnetic resonance imaging
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Papillomavirus Infections, Early Detection of Cancer
HPV Self-sampling for Women Who do Not Attend Cervical Cancer Screening Programme
This study aims to test the effectiveness and cost-effectiveness of two different strategies of home-delivered HPV self-sampling, in comparison to the standard of care strategy, to increase adherence to cervical cancer screening.
- Conditions
- Papillomavirus Infections, Early Detection of Cancer, Cervix Cancer, Self-Examination
- Trial name
- HERSELF (NCT06371118)
- Testing
- Directly mailed self-sampling kit to collect a vaginal sample, Mailed self-sampling kit to collect a vaginal sample after opt-in prodecure, Standard of care - screening in a clinical setting
- Where
- 2 sites in Portugal
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Lung Cancer
Sputum Labeling Utilizing Synthetic Meso-Tetra (4-Carboxyphenyl) Porphine (TCPP) for Detection of Lung Cancer
This is a single center study to assess the efficacy of CyPath® Early Detection Lung Cancer Assay to detect lung cancer cells from deep lung sputum.
- Trial name
- NCT02388074
- Testing
- CyPath®
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- bioAffinity Technologies Inc.
Esophageal Squamous Cell Carcinoma, Esophageal Squamous Dysplasia
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma
In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal…
- Trial name
- NCT05028725
- Testing
- EsophaCap Sponge, Chromoendoscopy, EsoCAN assay
- Where
- 2 sites in Tanzania
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco