Clinical trials: Early Intervention
Language Development Disorders
EMT en Español for Spanish-speaking Toddlers With Language Delays
The goal of the study is to conduct an initial efficacy study of a promising therapist and caregiver-implemented communication intervention to improve language and school readiness skills in low-income Spanish-speaking children…
- Trial name
- NCT04066049
- Testing
- EMT en Español
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Language Disorders in Children, Learning; Developmental Disorder
Impact of Teacher Training and the Introduction of Early Adjustments on the Developmental Trajectory of Children at Risk of SLLD in Pre-school.
The high incidence of neurodevelopmental disorders, including specific language and learning disorders, and their profund impact on the schooling of the children concerned remains a major public health concern.
- Trial name
- PRISME-TSLA (NCT06062147)
- Testing
- Teacher training
- Where
- Reunion
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Complication of Surgical Procedure, Infections
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are due to intraoperative…
- Trial name
- NCT06513598
- Testing
- Major visceral surgery for gastrointestinal cancer
- Where
- 2 sites in Lithuania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Cardiovascular Risk Factor
Precision Assignment of Intervention Messages to Promote Physical Activity - Precision AIM
Our goal is to develop personalized decision rules for selecting the frequency, timing, and content of messages to promote physical activity.
- Trial name
- NCT04972279
- Testing
- Digital message (text + image)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Early Education, Early Childhood Development
Kenya Preschool Study
This research project aims to design and evaluate an innovative model for childcare provision in rural Kenya that emphasizes child development and economic participation for women in a cost-effective manner.
- Trial name
- NCT07506603
- Testing
- PP1
- Where
- Kenya
- Volunteers
- 2,017 people, healthy volunteers welcome
- Sponsor
- Yale University
Couples Therapy, Military Family
"Up-Armoring" At-Risk Military Couples: A Stepped Approach to Early Intervention and Strengthening of Military Families
The study tested whether giving young, partnered military service members access to an online relationship help website would help prevent future relationship problems compared to partnered service member who did not have access…
- Trial name
- NCT06948877
- Testing
- ARMOR Online
- Where
- United States
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- Wright State University
Alcohol Abuse
Alcohol Early Intervention for Freshmen
Alcohol abuse among college students is a significant and long-standing public health issue. The transition into college is marked by substantial increases in alcohol abuse and problems, suggesting the importance of interventions…
- Trial name
- Transitions (NCT00852033)
- Testing
- Brief Motivational Intervention (BMI), Parent Based Intervention plus booster, Combined brief motivational intervention and parent based intervention plus boosters for both interventions
- Where
- United States
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Antibiotic, Allergic Diseases
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Early antibiotic exposure is an important environmental factor that disrupts the establishment of the infant gut microbiota and leads to microbial dysbiosis.
- Conditions
- Antibiotic, Allergic Diseases, Infants, Probiotic
- Trial name
- NCT07532421
- Testing
- Probiotic mixture
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Early Detection of Cancer, Colon Cancer
Elders Preferences in Care Decisions
The purpose of this research study is to explore ways to improve appropriate colorectal cancer (CRC) screening in the elderly by attempting to target screening in those most likely to benefit and avoiding screening in those least…
- Conditions
- Early Detection of Cancer, Colon Cancer, Decision Making, Patient-Centered Care
- Trial name
- EPIC-D (NCT01575990)
- Testing
- Making A Decision About CRC Screening, Drivers 65 Plus
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Memory Loss (Excluding Dementia), Healthy Lifestyle
Brain Health Program for Older Adults With Subjective Cognitive Decline
The investigators will compare two brain health programs in older adults with subjective cognitive decline and lifestyle risk factors for dementia.
- Conditions
- Memory Loss (Excluding Dementia), Healthy Lifestyle, Risk Reduction Behavior
- Trial name
- NCT05934136
- Testing
- My Healthy Brain 1, My Healthy Brain 2
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Developmental Disabilities
A Self-Instructional Online Program for Early Childhood and Elementary Teachers Supporting Autistic Children and Children With Developmental Delays
The goal of this clinical trial is to evaluate the preliminary effectiveness and acceptability of a self-instructional, web-based teacher training program designed to support the development of autistic children and children with…
- Conditions
- Autism Spectrum Disorder, Developmental Disabilities, Developmental Delay, Teacher Training
- Trial name
- SEED (NCT07524192)
- Testing
- SEED Online Self-Instructional Program, Comparison Educational Materials (Kit for Kids)
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boin Choi
Premature Birth
2-Brain Regulation to Achieve Improved Neuroprotection During Early Development
Each year 15 million infants are born preterm (PT). Even without severe comorbidities, they are exposed to sensory stress during the Neonatal Intensive Care Unit (NICU) stay and are at greater risk of neurodevelopmental problems…
- Trial name
- 2-BRAINED (NCT06659809)
- Testing
- Tele-care video-feedback intervention (TVFI)
- Where
- 2 sites in Italy
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Lung Cancer, Colorectal Cancer
ProSight: A Multi-centre Interventional Study Evaluating MCED in Asymptomatic Population
This is a prospective, multi-centre interventional study evaluating the feasibility of blood-based multi-cancer early detection test in asymptomatic screening cohort.
- Conditions
- Lung Cancer, Colorectal Cancer, Liver Cancer, Grastic Cancer
- Trial name
- NCT06790355
- Testing
- multi-cancer early detection
- Where
- 4 sites in China
- Volunteers
- 2,527 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Early Onset Alzheimer Disease, Frontotemporal Dementia
RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia
The RHAPSODY-plus project consists of two parts. In a first step carers of people with young onset dementia (YOD; onset before the age of 65) have the opportunity to use the RHAPSODY online program (Kurz et al., 2016) to inform…
- Trial name
- RHAPSODY-plus (NCT03923517)
- Testing
- RHAPSODY online program and MEET online sessions
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Early Intervention, Educational (Head Start and Early Head Start Access and Participation)
Head Start REACH: Strengthening Outreach, Recruitment and Engagement Approaches With Families
Mathematica, funded by the Administration for Children and Families (ACF) Office of Planning, Research, and Evaluation (OPRE) in the U.S.
- Trial name
- HSREACH (NCT05145933)
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Mathematica Policy Research, Inc.
Infant Development
Mobile Health Intervention for Infants in Guatemala (18-m Intervention)
Promoting optimal development for children at risk in low- and middle-income countries (LMICs) is an important global health priority.
- Trial name
- NCT06195358
- Testing
- Mobile Health (Smartphone) Application, Printed Caregiving Materials
- Where
- Guatemala
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Acute Aortic Dissection
Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection
The morbidity rate of Stanford A type Acute Aortic Dissection（AAD） has been increasing, about 5-10/100,000* per year. Emergency surgery has been the main treatment for Acute Aortic Dissection, however perioperative mortality rate…
- Trial name
- NCT01894334
- Testing
- Ulinastatin, Tranexamic acid, Edaravone
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Thirst; Due to Deprivation of Water, Patient Satisfaction
Early Oral Hydration in Relieving Postoperative Thirst
This study aims to evaluate whether allowing early oral hydration on demand effectively relieves postoperative thirst and enhances patient satisfaction in individuals undergoing urological endoscopic procedures
- Trial name
- NCT07563530
- Testing
- Early oral hydration, No early oral hydration (As per Standard PACU Protocol)
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Bone Strength, Growth
Vitamin D Intervention in Infants - 6 Years Follow-up (VIDI2)
Exposure to vitamin D intervention in early life may have permanent effects on physiology and metabolism. Bone growth and mineralization, development of immunity, body composition and brain structure and functioning may be…
- Conditions
- Bone Strength, Growth, Body Composition, Infection
- Trial name
- VIDI2 (NCT04302987)
- Where
- Finland
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Helsinki