Clinical trials: Early Interventions
Neurodevelopmental Disorders, Autism Spectrum Disorder
Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder
H1The primary goal of this intervention study is to learn if very early parent-mediated intervention in children at risk for neurodevelopmental disorders in the first year of life can be implemented in routine care, positively…
- Trial name
- ERI-SIBS (NCT06512649)
- Testing
- Early intervention, Active monitoring
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Smoking Reduction, Asthma in Children
Early Life Intervention in Pediatrics Supported by E-health - SMOKE
Unrestricted parental smoking habits are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of non-communicable diseases (NCDs).
- Conditions
- Smoking Reduction, Asthma in Children, Wheezing, Non-Communicable Disease
- Trial name
- ELIPSE-II (NCT06311162)
- Testing
- Life-Style app
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Early Interventions, Preterm Infants
Effects of Early Behavioral and Transaction Interventions on Preterm Infants' and Parents' Biopsychosocial Well-being
This randomized controlled trial will use a longitudinal repeated-measures design to examine the effects of two interventions, behavioral support interventions and a parent-infant transactional program, on parents' stress, PPD…
- Conditions
- Early Interventions, Preterm Infants, Parent-Child Relations
- Trial name
- NCT03013023
- Testing
- BS, Routine care, PITP
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Child Development
PROmoting Early Childhood Outside (PRO-ECO)
Licensed early learning and childcare centres (ELCCs) can provide children with rich opportunities for outdoor play that they may not otherwise experience in their home or community.
- Trial name
- PRO-ECO (NCT05073380)
- Testing
- Intervention Group - PRO-ECO Intervention, Wait List Group - Normal Daily Practice
- Where
- Canada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Risk Factor
Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity
Our goal is to develop personalized decision rules for selecting the frequency, timing, and content of messages to promote physical activity.
- Trial name
- RandomAIM (NCT03907683)
- Testing
- Short Message with Text and Optional Image
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Penn State University
HIV Infections
Affect Management Intervention for Early Adolescents Wtih Mental Health Problems
Adolescents are at risk for HIV because of sexual and drug use behavior initiated during early adolescence, and those with mental health problems appear to be particularly susceptible.
- Trial name
- Project TRAC (NCT00741975)
- Testing
- Affect Management, General Health Promotion
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Stress
Applying Mindfulness for Economically Disadvantaged Families
The purpose of this study is to assess the effectiveness of a family-based mindfulness intervention (FBMI) in reducing parental stress and promoting child adjustment.
- Trial name
- NCT03662867
- Testing
- Family-based mindfulness intervention, Wait-list
- Where
- Hong Kong
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Domestic Violence
Ke Ala Lokahi Demonstration Project for Sexual and Domestic Violence Prevention
The purpose of the project is to examine the efficacy of a culturally-based intervention, compared to standard agency services, in enhancing self-care among Native Hawaiian women and decreasing IPV/SV perpetration and related…
- Trial name
- NCT00164268
- Testing
- Ke Ala Lokahi (Native Hawaiian cultural intervention)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women
Trial to Evaluate the Impact of Various Interventions to Increase the Uptake of Surveillance Mammography in Eligible Women in Singapore
Breast cancer is the most common cancer among women in Singapore, with more than 70 women out of every 100,000 being diagnosed each year.
- Trial name
- NCT06733155
- Testing
- Financial intervention, Lottery intervention, Health Messages
- Where
- Singapore
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia
Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and…
- Conditions
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- Trial name
- MUSENGAGE (NCT06688968)
- Testing
- neuropsychologist interview, questionnaire
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Anxiety
Early Intervention AND NURSING Support for an " Involuntary Commitment Procedure " for a Close Relative
In a context of first hospitalization under the constraint of a relative in psychiatric emergencies: effect of an early intervention and a 6-month nursing follow-up on the anxious experience of third party persons effect of…
- Trial name
- Vécu/Tiers/Psy (NCT03510039)
- Testing
- Early device / Follow up, Usual care
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Autism
Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study
Autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. While the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for…
- Trial name
- NCT02807766
- Testing
- Behavior modification, Behavior modification and sensory integration training, Behavior modification and applied behavioral analysis
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Anxiety, Depression in Adolescence
Co-designing Adaptations of a Digital Mental Health Intervention (Wysa) for Adolescent Girls With Anxiety or Depression in Rural India
The goal of this study is to culturally and contextually adapt Wysa, an evidence-based AI-powered digital mental health intervention (DMHI), for adolescent girls (ages 13-18) with symptoms of anxiety and/or depression in rural…
- Conditions
- Anxiety, Depression in Adolescence, Anxiety Disorder of Adolescence
- Trial name
- NCT07595029
- Testing
- Digital psychosocial tool
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Wysa
GDM
Effect of Early Lifestyle Intervention on Perinatal Outcomes in High-risk Women for Gestational Hyperglycemia
This study aims to explore whether early intervention for high-risk groups of gestational hyperglycemia can improve insulin resistance and effectively prevent the occurrence of GDM, and evaluate which pathophysiological subtypes…
- Trial name
- NCT07141173
- Testing
- Individual lifestyle management
- Where
- China
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Tianjin Central Hospital of Gynecology Obstetrics
Diabetes, Cervical Cancer (Early Detection)
Improving Cervical Cancer Prevention Among Women Living With Chronic Conditions.
Our overarching goal is to adapt and test the PINPOINT intervention -PatIent Navigation for the Prevention of CervIcal CaNcer inTervention.
- Conditions
- Diabetes, Cervical Cancer (Early Detection), Obesity & Overweight
- Trial name
- PINPOINT (NCT07351110)
- Testing
- patient navigation and self-collection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 2 Diabetes, Subjective Cognitive Decline
China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society.
- Conditions
- Type 2 Diabetes, Subjective Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06650969
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Neutropenia
AMS Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients
Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy.
- Trial name
- NCT05793073
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Child Maltreatment
Evaluation of a 2-session Parent Training Programme for Caregivers of Younger Children in Zimbabwe
A pilot, exploratory cluster Randomised Controlled Trial (RCT) with two arms will be conducted to test a two-session parent training programme for caregivers of children enrolled in early childhood development classes in Harare…
- Trial name
- NCT06431321
- Testing
- Tabudira Parenting Intervention for Early Childhood Development, Nutritional guide for younger children
- Where
- Zimbabwe
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Psychotic Disorder
Treating Early Stages With an Intervention Targeting Cognitive Reserve
This study proposes continuity in the implementation of a psychological approach program to enhance cognitive reserve (CR) in children, adolescent and young adults, off-springs of patients with schizophrenia or bipolar disorder…
- Trial name
- TESORO (NCT05288049)
- Testing
- Enhancing cognitive reserve, Support therapy
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona